Construction of and evaluation of the immune response to two recombinant pseudorabies viruses expressing the B119L and EP364R proteins of African swine fever virus

Geng, Xin-Mei; Xi, Ying-Mu; Huang, Xiang-Mei; Wang, Yang-Lin; Wang, Xu-Ying; Ouyang, Kang; Chen, Ying; Wei, Zu-Zhang; Qin, Yi-Feng; Huang, Wei-Jian

doi:10.1007/s00705-023-05935-y

Arch Virol

2024

DOI: 10.1007/s00705-023-05935-y

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Construction of and evaluation of the immune response to two recombinant pseudorabies viruses expressing the B119L and EP364R proteins of African swine fever virus

Xin-Mei Geng,

Ying-Mu Xi,

Xiang-Mei Huang

et al.

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Cited by 2 publications

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When ASFV Infection Meets the cGAS-STING Signaling Pathway

Chen,

Shang,

Wei

et al. 2024

Transboundary and Emerging Diseases

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The African swine fever virus (ASFV) has the ability to infect both wild boars and domestic pigs, regardless of their breeds or ages, often resulting in a mortality rate of 100%. Host innate immunity is the most important defense weapon against invasion of pathogenic microbial infection. cGAS-STING signaling pathway is one of the greatest discoveries of the twenty-first century, which is crucial in host’s innate immune response. Recent studies have found that the interaction between cGAS/STING pathway and ASFV plays a key role during ASFV infection. At the same time, ASFV has also evolved different strategies to evade the killing of the host cGAS/STING pathway and promote its survival. Here, we review the latest progress in the interaction between ASFV infection, cGAS/STING pathways, and their related molecular mechanisms, aiming to provide new ideas for further research on the pathogenesis of ASFV, the development of vaccines and therapeutic drugs.

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When ASFV Infection Meets the cGAS-STING Signaling Pathway

Chen,

Shang,

Wei

et al. 2024

Transboundary and Emerging Diseases

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Comprehensive Characterization of the Genetic Landscape of African Swine Fever Virus: Insights into Infection Dynamics, Immunomodulation, Virulence and Genes with Unknown Function

Venkateswaran,

Prakash,

Nguyen

et al. 2024

Animals

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African Swine Fever (ASF) is a lethal contagious hemorrhagic viral disease affecting the swine population. The causative agent is African Swine Fever Virus (ASFV). There is no treatment or commercial vaccine available at present. This virus poses a significant threat to the global swine industry and economy, with 100% mortality rate in acute cases. ASFV transmission occurs through both direct and indirect contact, with control measures limited to early detection, isolation, and culling of infected pigs. ASFV exhibits a complex genomic structure and encodes for more than 50 structural and 100 non-structural proteins and has 150 to 167 open reading frames (ORFs). While many of the proteins are non-essential for viral replication, they play crucial roles in mediating with the host to ensure longevity and transmission of virus in the host. The dynamic nature of ASFV research necessitates constant updates, with ongoing exploration of various genes and their functions, vaccine development, and other ASF-related domains. This comprehensive review aims to elucidate the structural and functional roles of both newly discovered and previously recorded genes involved in distinct stages of ASFV infection and immunomodulation. Additionally, the review discusses the virulence genes and genes with unknown functions, and proposes future interventions.

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Construction of and evaluation of the immune response to two recombinant pseudorabies viruses expressing the B119L and EP364R proteins of African swine fever virus

Cited by 2 publications

References 54 publications

When ASFV Infection Meets the cGAS-STING Signaling Pathway

When ASFV Infection Meets the cGAS-STING Signaling Pathway

Comprehensive Characterization of the Genetic Landscape of African Swine Fever Virus: Insights into Infection Dynamics, Immunomodulation, Virulence and Genes with Unknown Function

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