Construction of biconcave hemoglobin-based microcapsules and electrochemical evaluation for its ability of oxygen carry

Yu, Chunmei; Qian, Dongping; Huang, Xin; Han, Fengfeng; Bao, Ning; Gu, Hongchen

doi:10.1016/j.snb.2017.09.166

Cited by 14 publications

(11 citation statements)

References 38 publications

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“…The spectrophotometer was adopted to detect the absorbance of different concentrations of BSA protein at 590 nm. The hemolysis rate of RBCs is an important indicator for evaluating biocompatibility [ 13 , 14 ]. After RBCs cells were resuspended and cultured with 0.1 mg/mL, 0.5 mg/mL, and 1 mg/mL Pul-PGEA, the morphology of RBCs cells was observed under a microscope.…”

Section: Methodsmentioning

confidence: 99%

RETRACTED ARTICLE: Protective effect of vasostatin-1 plasmid-like nanoparticles on aortic aneurysm and its mechanism

Wang

Peng

et al. 2021

Bioengineered

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Vasostatin 1 (VS-1) plays an important role in the regulation of various tissue injury and repair processes, but its role in aortic aneurysm remains unclear. The plasmid-like nanoparticles containing the vasostatin-1 gene Pul-PGEA-pCas-sgVs-1 were constructed, and their guarantee, safety, hemolysis, and particle size were analyzed. Eighty-four eight-week-old male ApoE-mice were randomly divided into blank group (without any treatment), model group (Ang II aortic aneurysm model + tail injection of PBS), control group (modeling + tail injection of Pul-PGEA-pCas9), and experimental group (modeling + tail injection of Pul-PGEA-pCas-sgVs-1), with 21 rats in each group. The incidence, mortality, and maximum diameter of abdominal aortic aneurysm (AAA) and the contents of high sensitivity C-reactive protein (HS-CRP), soluble intercellular adhesion molecule-1 (ICAM-1), soluble vascular cell adhesion molecule-1 (VCAM-1), and TNF-a in serum were compared in different groups of mice. The results showed that Pul-PGEA-pCas-sgVs-1 had good biosafety and transfection ability. The maximum diameter of abdominal aorta, incidence of abdominal aortic aneurysm, mortality, and the expression levels of HS-CRP, ICAM-1, VCAM-1, and TNF-a in the experimental group were lower than those in the model group ( P < 0.05). These results indicated that the plasmid-like nanoparticles Pul-PGEA-pCas-sgVs-1 can inhibit the development of aorta by down-regulating the expression of inflammatory factors, which played a good protective role on the aorta.

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Section: Methodsmentioning

confidence: 99%

RETRACTED ARTICLE: Protective effect of vasostatin-1 plasmid-like nanoparticles on aortic aneurysm and its mechanism

Wang

Peng

et al. 2021

Bioengineered

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“…During co-precipitation process, Hb molecules were captured on the particle surface due to high adsorption capacity of DS. [134] Huang et al synthesized erythrocyte-like Cu 1.8 S NPs via an ecofriendly one-step solvothermal reaction with PVP. [135] Zhang et al reported a facile and controllable protocol to synthesize hierarchical erythrocyte-like NPs of mesoporous SiO 2 , which were endowed with multi-stack structure by using 11-mercaptoundecanoic acid (MUA) and CTAB as co-surfactants.…”

Section: Biconcave Discoid Particlesmentioning

confidence: 99%

Erythrocyte‐Inspired Functional Materials for Biomedical Applications

et al. 2022

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Erythrocytes are the most abundant cells in the blood. As the results of long‐term natural selection, their specific biconcave discoid morphology and cellular composition are responsible for gaining excellent biological performance. Inspired by the intrinsic features of erythrocytes, various artificial biomaterials emerge and find broad prospects in biomedical applications such as therapeutic delivery, bioimaging, and tissue engineering. Here, a comprehensive review from the fabrication to the applications of erythrocyte‐inspired functional materials is given. After summarizing the biomaterials mimicking the biological functions of erythrocytes, the synthesis strategies of particles with erythrocyte‐inspired morphologies are presented. The emphasis is on practical biomedical applications of these bioinspired functional materials. The perspectives for the future possibilities of the advanced erythrocyte‐inspired biomaterials are also discussed. It is hoped that the summary of existing studies can inspire researchers to develop novel biomaterials; thus, accelerating the progress of these biomaterials toward clinical biomedical applications.

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“…[162,163] These properties allow RBCs to change both their shape and morphology when passing through the microvascular circulation. [164,165] Alternatively, Yu et al [168] prepared RBCs-shaped microparticles by co-precipitation of Dex together with Hb and calcium hydroxide (Ca(OH)2), followed by GA cross-linking ( Figure 8A).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Recent and prominent examples of nano- and microarchitectures as hemoglobin-based oxygen carriers

Jansman

Hosta‐Rigau

2018

Advances in Colloid and Interface Science

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Construction of biconcave hemoglobin-based microcapsules and electrochemical evaluation for its ability of oxygen carry

Cited by 14 publications

References 38 publications

RETRACTED ARTICLE: Protective effect of vasostatin-1 plasmid-like nanoparticles on aortic aneurysm and its mechanism

RETRACTED ARTICLE: Protective effect of vasostatin-1 plasmid-like nanoparticles on aortic aneurysm and its mechanism

Erythrocyte‐Inspired Functional Materials for Biomedical Applications

Recent and prominent examples of nano- and microarchitectures as hemoglobin-based oxygen carriers

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