Construction of Biocompatible Dual-Drug Loaded Complicated Nanoparticles for in vivo Improvement of Synergistic Chemotherapy in Esophageal Cancer

Zhan, Wenbin; Li, Hanrui; Guo, Yingying; Du, Getao; Wu, Yayan; Zhang, Dexin

doi:10.3389/fonc.2020.00622

Cited by 15 publications

(6 citation statements)

References 44 publications

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“…In overall, GP nanoemulsions (GEM and PTX dually encapsulated TAemulsions) exhibited higher cytotoxicity than single drug encapsulated nanoemulsions (GEMencapsulated TA-emulsions or PTX-encapsulated TA-emulsions (Fig. 4b) with similar result from dually loadable polymeric drug carriers [53][54][55][56] . In detail, GP1000 treatment exhibited 57.0 ± 0.0% cell viability, compared with G1000 (84.0 ± 9.9%) and P1000 (83.4 ± 7.2%) treated cell viability.…”

Section: Resultsmentioning

confidence: 99%

Metal-Phenolic Coordination mediated Nanoemulsions for All-in-One Drug Delivery

Jeon,

Park,

Lee

et al. 2024

Preprint

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Combination chemotherapy is a promising strategy for cancer treatment, enhancing antitumor efficacy while minimizing drug resistance and mitigating the risk of single-drug overdose toxicity. The complexity of pancreatic cancer treatment with its unique avascular and protective stromal barrier, poses challenges in reaching the tumor region – necessitating advanced combination therapy. While polymeric drug delivery carriers for combination chemotherapy have been developed through the synthesis of amphiphilic polymers, this process can be time-consuming and laborious. Polymer entanglement-based drug encapsulation has been limited in achieving high drug encapsulation efficiency because of the intrinsic preference for the localization or encapsulation of drugs based on their polarity. Herein a novel approach was employed, utilizing dynamic bonding and supramolecular assembly at the oil/water interface for drug encapsulation. An emulsion interface was formulated by metal-phenolic coordinate bonds, stabilizing nanoemulsions with diameters ranging from 50 to 100 nm for three weeks. These nanoemulsions co-encapsulated hydrophilic (gemcitabine) and hydrophobic (paclitaxel) anticancer drugs. Moreover, the cellular toxicity of the dual drugs-encapsulated nanoemulsions treatment showed better toxicity (57.0 ± 0.0%) than that of the gemcitabine only-encapsulated (84.0 ± 9.9%) and paclitaxel only-encapsulated (83.4 ± 7.2%) nanoemulsion treatments, demonstrating the potential of multidrug delivery carriers for synergistic combination therapy.

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Section: Resultsmentioning

confidence: 99%

Metal-Phenolic Coordination mediated Nanoemulsions for All-in-One Drug Delivery

Jeon,

Park,

Lee

et al. 2024

Preprint

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“…Zhan encapsulated β-elemene within the pores of mesoporous silica nanoparticles, while artemisinin was electrostatically adsorbed onto the nanoparticle surface, resulting in a synergistic dual-drug nanosystem. This nanosystem demonstrated excellent antitumor effects both in vitro and in vivo , offering a promising therapeutic option for esophageal cancer treatment ( Zhan et al, 2020 ). Zou et al employed a simple biosynthetic method to prepare copper oxide nanoparticles (CuO nanoparticles) using an extract from Astragalus membranaceus at ambient temperature.…”

Section: The Exploration Of Nanocarriers In Chinese Patent Medicinementioning

confidence: 99%

Nanodrugs systems for therapy and diagnosis of esophageal cancer

Zhang

Yue

et al. 2023

Front. Bioeng. Biotechnol.

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With the increasing incidence of esophageal cancer, its diagnosis and treatment have become one of the key issues in medical research today. However, the current diagnostic and treatment methods face many unresolved issues, such as low accuracy of early diagnosis, painful treatment process for patients, and high recurrence rate after recovery. Therefore, new methods for the diagnosis and treatment of esophageal cancer need to be further explored, and the rapid development of nanomaterials has brought new ideas for solving this problem. Nanomaterials used as drugs or drug delivery systems possess several advantages, such as high drug capacity, adjustably specific targeting capability, and stable structure, which endow nanomaterials great application potential in cancer therapy. However, even though the nanomaterials have been widely used in cancer therapy, there are still few reviews on their application in esophageal cancer, and systematical overview and analysis are deficient. Herein, we overviewed the application of nanodrug systems in therapy and diagnosis of esophageal cancer and summarized some representative case of their application in diagnosis, chemotherapy, targeted drug, radiotherapy, immunity, surgery and new therapeutic method of esophageal cancer. In addition, the nanomaterials used for therapy of esophageal cancer complications, esophageal stenosis or obstruction and oesophagitis, are also listed here. Finally, the challenge and the future of nanomaterials used in cancer therapy were discussed.

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“…Evidence suggests that compared with traditional formulations, nanomedicines have unparalleled advantages in cancer treatment. The clinical translation of nanomedicine may provide better treatment options for EC patients 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Bovine serum albumin and folic acid-modified aurum nanoparticles loaded with paclitaxel and curcumin enhance radiotherapy sensitization for esophageal cancer

Gao,

Zhou,

Jiang

et al. 2023

International Journal of Radiation Biology

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Background: Nanocarrier systems have been used in the study of esophageal cancer (EC) and other diseases, with significant advantages in improving the non-targeted and non-specific toxicity of traditional formulations. Some chemotherapeutic drugs and high atomic number nanomaterials have sensitization effects on ionizing radiation and can be used as chemoradiation sensitizers. Methods:We selected bovine serum albumin (BSA) and folic acid (FA)-modified aurum (Au) nanoparticles, which were core-loaded with paclitaxel (PTX) and curcumin (CUR). The basic characteristics of FA-BSA-Au@PTX/CUR nanomedicines were evaluated by transmission electron microscopy, Fourier transform infrared spectroscopy, and Malvern Zetasizer. The encapsulation and release of drugs were tracked by ultraviolet-visible spectrophotometry (UV-Vis). The biological toxicity and radiotherapy sensitization effect of FA-BSA-Au@PTX/CUR were observed by cell viability, colony formation, cell apoptosis, cell cycle distribution, and γ-H2AX analysis experiments. Results:The prepared nanomedicines showed good stability and spherical morphology.The results of cell uptake and cell viability detection showed that FA-BSA-Au@PTX/CUR could specifically target EC cell KYSE150 and exert a certain inhibitory effect on proliferation, without obvious toxicity on healthy cells Het-1A. In addition, the results of colony formation experiment, cell apoptosis detection, cell cycle distribution, and γ-H2AX analysis showed that compared with X-rays alone, FA-BSA-Au@PTX/CUR combined with X-rays exhibited relatively stronger radiotherapy sensitization and anti-tumor activity. Conclusion:FA-BSA-Au@PTX/CUR could target EC cancer cells and could be used as a safe and effective radiotherapy sensitizer to improve the radiotherapy efficacy of EC.

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Construction of Biocompatible Dual-Drug Loaded Complicated Nanoparticles for in vivo Improvement of Synergistic Chemotherapy in Esophageal Cancer

Cited by 15 publications

References 44 publications

Metal-Phenolic Coordination mediated Nanoemulsions for All-in-One Drug Delivery

Metal-Phenolic Coordination mediated Nanoemulsions for All-in-One Drug Delivery

Nanodrugs systems for therapy and diagnosis of esophageal cancer

Bovine serum albumin and folic acid-modified aurum nanoparticles loaded with paclitaxel and curcumin enhance radiotherapy sensitization for esophageal cancer

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