Construction of bionic nanoparticles camouflaged with macrophage membranes for drug delivery in breast cancer

Yan, Jie; Ji, Shuaishuai; Tian, Chao; Yu, Zhenyan; Zhang, Jing; Hu, Man; Cheng, Xiuzhen; Huo, Qiang

doi:10.1016/j.jddst.2023.104433

Cited by 6 publications

(6 citation statements)

References 58 publications

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“…In particular, the encapsulation of M1 macrophages caused DOX/CAT@PLGA-M1 to display a significantly higher uptake in the 4T1 cells. Therefore, VCAM-1 in tumor cells could interact with specific integrins (α4 and β1) to promote the DOX/CAT@PLGA-M1 uptake by 4T1 cells and specifically target tumor sites [ 12 ].…”

Section: Resultsmentioning

confidence: 99%

“…Pharmaceutics 2023, 15, x FOR PEER REVIEW 9 of 14 cells could interact with specific integrins (α4 and β1) to promote the DOX/CAT@PLGA-M1 uptake by 4T1 cells and specifically target tumor sites [12]. Furthermore, cell scratch tests were performed to investigate the inhibitory effects of different NPs on cell migration (Figure 6).…”

Section: In Vitro Cellular Level Studymentioning

confidence: 99%

“…Macrophages that are prevalent in the TME have good tumor-homing ability, which is directly related to tumor progression and metastasis [ 11 ]. Macrophage membranes contain α4 integrin and CC chemokine receptor 2 (CCR2), making them ideal candidates for tumor targeting, and have been successfully used in bionic systems for drug delivery to tumor or inflammatory sites [ 12 , 13 ]. However, living cells are not suitable as drug carriers due to their disadvantages such as short survival time and difficult storage.…”

Section: Introductionmentioning

confidence: 99%

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M1 Macrophage-Biomimetic Targeted Nanoparticles Containing Oxygen Self-Supplied Enzyme for Enhancing the Chemotherapy

Zhang,

Gu,

et al. 2023

Pharmaceutics

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Tumor hypoxia is considered one of the key causes of the ineffectiveness of various strategies for cancer treatment, and the non-specific effects of chemotherapy drugs on tumor treatment often lead to systemic toxicity. Thus, we designed M1 macrophage-biomimetic-targeted nanoparticles (DOX/CAT@PLGA-M1) which contain oxygen self-supplied enzyme (catalase, CAT) and chemo-therapeutic drug (doxorubicin, DOX). The particle size of DOX/CAT@PLGA-M1 was 202.32 ± 2.27 nm (PDI < 0.3). DOX/CAT@PLGA-M1 exhibited a characteristic core-shell bilayer membrane structure. The CAT activity of DOX/CAT@PLGA-M1 was 1000 (U/mL), which indicated that the formation of NPs did not significantly affect its enzymatic activity. And in vitro drug release showed that the cumulative release rate of DOX/CAT@PLGA-M1 was enhanced from 26.93% to 50.10% in the release medium of hydrogen peroxide, which was attributed to the reaction of CAT in the NPs. DOX/CAT@PLGA-M1 displayed a significantly higher uptake in 4T1 cells, because VCAM-1 in tumor cells interacted with specific integrin (α4 and β1), and thereby achieved tumor sites. And the tumor volume of the DOX/CAT@PLGA-M1 group was significantly reduced (0.22 cm3), which further proved the active targeting effect of the M1 macrophage membrane. Above all, a novel multifunctional nano-therapy was developed which improved tumor hypoxia and obtained tumor targeting activity.

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Section: Resultsmentioning

confidence: 99%

Section: In Vitro Cellular Level Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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M1 Macrophage-Biomimetic Targeted Nanoparticles Containing Oxygen Self-Supplied Enzyme for Enhancing the Chemotherapy

Zhang,

Gu,

et al. 2023

Pharmaceutics

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“…Therefore, increasing attention has been paid to this biomembrane-mimetic strategy. For example, erythrocyte membrane-coated nanoparticles were capable of immune escape and prolonged blood circulation [64]; cancer cell membrane-camouflaged nanomaterials were designed to target homotypic cancer cells [65]; neutrophil membrane-wrapped nanodrugs were exploited to be recruited to inflammatory sites [66,67]; the biotropism of platelets to vasculature trauma could be utilized to target the residual microtumors after tumor surgical resection [68,69]; macrophage membranes can be employed to endow nanoparticles tumor-homing abilities [70]. Zhang et al [71] developed a MOF-based biomimetic nanoreactor in which glucose oxidase (GOX) and the prodrug tirapazamine (TPZ) were encapsulated in an erythrocyte membrane-camouflaged ZIF-8 NPs to obtain TPZ-GOX-ZIF-8 NPs@erythrocyte membrane (TGZ@eM).…”

Section: Biomembrane Camouflagingmentioning

confidence: 99%

Engineering zeolitic imidazolate framework-8 nanoparticles for smart drug delivery systems

Wu,

Huang,

et al. 2024

Nano Ex.

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Zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs) are emerging metal-organic framework nanomaterials composed of 2-methylimidazole and zinc ions, which are widely used in biomedical fields due to their distinctive features such as high porosity, bioresponsive degradation, and superior biocompatibility. Especially, the advanced research of ZIF-8 NPs in smart drug delivery systems is providing unique insights into the rational design of versatile nanomedicines for the treatment and diagnosis of serious diseases. This article provides a comprehensive review and outlook on ZIF-8 NPs-based smart drug delivery systems (SDDSs) including the synthesis methods, drug loading strategies, surface modification, and stimuli-responsive release. In particular, we focus on the advantages of ZIF-8 NPs-based drug loading strategies between the metal coordination-based active loading and the physical packaging-based passive loading. Finally, the opportunities and challenges of ZIF-8 NPs as smart drug delivery carriers are discussed.

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“…Furthermore, Zn 2+ has excellent antibacterial, anti‐inflammatory and osteogenic capability which means ZIF‐8 exhibits great potential in fields like antibacteria [ 1 ] and bone tissue engineering. [ 2,3 ] More importantly, abundant metal active sites and dynamic microporosity endow ZIF‐8 with the ability to accommodate various guest molecules such as chemotherapeutic agents, [ 4,5 ] photosensitizers, [ 6,7 ] targeting agents, [ 8 ] biomolecules, [ 9,10 ] contrast agent [ 11 ] and so on. Hence, quantities of researches have been done on ZIF‐8 based materials in hot areas like bioimaging and drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

Tunable Zeolitic Imidazolate Framework‐8 Nanoparticles for Biomedical Applications

Wang,

Wu,

Ren

et al. 2023

Small Methods

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Zeolite imidazole framework‐8 (ZIF‐8) is the most prestigious one among zeolitic imidazolate framework (ZIF) with tunable dimensions and unique morphological features. Utilizing its synthetic adjustability and structural regularity, ZIF‐8 exhibits enhanced flexibility, allowing for a wide range of functionalities, such as loading of nanoparticle components while preserving biomolecules activity. Extensive efforts are made from investigating synthesis techniques to develop novel applications over decades. In this review, the development and recent progress of various synthesis approaches are briefly summarized. In addition, its interesting properties such as adjustable porosity, excellent thermal, and chemical stabilities are introduced. Further, five representative biomedical applications are highlighted based on above physicochemical properties. Finally, the remaining challenges and offered insights into the future outlook are also discussed. This review aims to understand the co‐relationships between structures and biomedical functionalities, offering the opportunity to construct attractive materials with promising characteristics.

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Construction of bionic nanoparticles camouflaged with macrophage membranes for drug delivery in breast cancer

Cited by 6 publications

References 58 publications

M1 Macrophage-Biomimetic Targeted Nanoparticles Containing Oxygen Self-Supplied Enzyme for Enhancing the Chemotherapy

M1 Macrophage-Biomimetic Targeted Nanoparticles Containing Oxygen Self-Supplied Enzyme for Enhancing the Chemotherapy

Engineering zeolitic imidazolate framework-8 nanoparticles for smart drug delivery systems

Tunable Zeolitic Imidazolate Framework‐8 Nanoparticles for Biomedical Applications

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