Construction of Cardiac Tissue Rings Using a Magnetic Tissue Fabrication Technique

Akiyama, Hisanori; Ito, Akira; Sato, Masanori; Kawabe, Yoshinori; Kamihira, Masamichi

doi:10.3390/ijms11082910

Cited by 36 publications

(29 citation statements)

References 21 publications

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“…Significant higher force was observed above 14% strain applied. Moreover, cells were densely packed and formed gap junction within the tissue which was confirmed by immunohistological analysis [188]. This stretchable property can be used to elongate the cells in the longitudinal direction, which can lead to tissue development with greater contractility [189].…”

Section: Cardiac Tissue Engineeringmentioning

confidence: 68%

“…8 cm/s) between cardiomyocytes within the cadiomyocyte sheet [148]. Another study showed potential use of Mag-TE in combination with ECM-mimicking technique for the fabrication of cardiac tissue ring [188]. The technique utilized mixture of type I collagen solution and commercially available Matrigel basement matrix (product of BD Biosciences, USA) in an optimized ratio, which was added to MCLs-labeled cardiomyocyte cell suspension.…”

Section: Cardiac Tissue Engineeringmentioning

confidence: 99%

See 1 more Smart Citation

Magnetic Nanoparticles in Tissue Regeneration

Tripathi¹,

Melo²,

D’Souza³

2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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The remote control operation and manipulation of cells is the prime advantage of magnetic nanoparticles. Control of specific cellular components in vitro as well as in vivo offers a powerful tool for the understanding of cellular functions and molecular signaling to scientist, which helps to develop precise therapeutic applications by clinicians. Cells surface or intracellular labeling by the use of magnetic nanoparticles as an investigation tool in its preliminary stage are successfully developed for the diagnostic and other biomedical applications. Currently, magnetic nanoparticle applications have prominently shifted their focus towards the engineering of cells and their fate in the determination at a molecular level for three-dimensional tissue regeneration. Magnetic force-assisted tissue engineering is often referred to as a "Mag-TE." This chapter is divided into two main sections. The first section presents an overview about the properties, synthesis and structure of magnetic nanoparticles. The second section focuses on how magnetic nanoparticles have been applied in the cell directed tissue engineering and regenerative medicine with potential future prospects.

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Section: Cardiac Tissue Engineeringmentioning

confidence: 68%

Section: Cardiac Tissue Engineeringmentioning

confidence: 99%

Magnetic Nanoparticles in Tissue Regeneration

Tripathi¹,

Melo²,

D’Souza³

2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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“…By manipulating the strength, shape, and orientation of the magnetic field, multi-directional cell arrangements can be produced in vitro and even directly in vivo. 34 Akiyama et al 35 applied a magnetic force-based tissue engineering technique to cardiac tissue fabrication. A mixture of extracellular matrix precursor and cardiomyocytes labeled with magnetic nanoparticles was added into a well containing a central polycarbonate cylinder.…”

Section: Magnetic Cell Patterningmentioning

confidence: 99%

“…The major advantage of the Mag-TE technique is the induction of cell-dense tissues mimicking native tissues, as demonstrated in the fabrication of cardiomyocyte, 40 myoblast cell sheets 36 and muscle tissues. 34 Okochi et al 37 fabricated a 3D cell patterning culture system using an external magnetic force and a pin holder, which enables the assembly of the magnetically labeded cells on the collagen gel-coated surface as array-like cell patterns, resulting in the development of a 3D in vivo culture model. The cells embedded in type I collagen showed a compacted, spheroid like configuration at each spot, and distinct, accelerated cell growth was observed in cancer model cells compared with control cells.…”

Section: Magnetic Cell Patterningmentioning

confidence: 99%

Magnetic Force-Based Tissue Engineering and Regenerative Medicine

Castro¹,

Mano²

2013

Journal of Biomedical Nanotechnology

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Among other biomedical applications, magnetic nanoparticles and liposomes have a vast field of applications in tissue engineering and regenerative medicine. Magnetic nanoparticles and liposomes, when introduced into cells to be cultured, maneuver the cell's positioning by the appropriate use of magnets to create more complex tissue structures than those that are achieved by conventional culture methods.

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“…Moreover, the tissue fabrication technique utilizing the magnetic nanoparticles described by the group of Ito et al [84] was recently tested in vitro for yet another cardiovascular application, namely, the cardiac tissue engineering. A mixture of collagen, Matrigel basement matrix, and cardiomyocytes labeled with the magnetic nanoparticles was added into a well containing a central polycarbonate cylinder.…”

Section: Vascular Tissue Engineering With Nanoparticlesmentioning

confidence: 99%

Nanomedicine in diagnostics and therapy of cardiovascular diseases: beyond atherosclerotic plaque imaging

Cicha

Lyer

Garlichs

2013

Nanotechnology Reviews

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Atherosclerosis results from the accumulation of the modified lipoproteins within the artery walls, which triggers complex vascular inflammatory processes. Although the pharmacologic agents for the treatment of clinical manifestations of atherosclerosis are available, their systemic delivery has serious disadvantages, such as considerable side effects or low efficacy at tolerated doses. Moreover, the treatment of atherosclerosis using the interventional techniques bears further shortcomings: the implanted stents require a lengthy antiplatelet therapy and carry the risk of in-stent restenosis. In the surgical approach to atherosclerosis, apart from the overall risk of open heart surgery, the lack of adequate venous material for bypasses constitutes a common problem. The nanotechnology has the potential to overcome the disadvantages of the current therapy of atherosclerosis, e.g., by the formation of nanosized assemblies for the earlier detection of atherosclerotic lesions and for cell-specific delivery of therapeutics. Replacing the current systemic pharmacological approach by a locally targeted treatment of plaques can substantially minimize the adverse effects, by lowering the drug cytotoxicity and reducing the required dosage. Moreover, a new generation of nanotechnological approaches to the revascularization procedures is now emerging, e.g., vascular tissue engineering utilizing the magnetic nanoparticles or the design of stents with the reduced risk of thrombosis and restenosis. This review discusses the possible applications of the nanomedical approaches in the treatment of cardiovascular diseases.

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Construction of Cardiac Tissue Rings Using a Magnetic Tissue Fabrication Technique

Cited by 36 publications

References 21 publications

Magnetic Nanoparticles in Tissue Regeneration

Magnetic Nanoparticles in Tissue Regeneration

Magnetic Force-Based Tissue Engineering and Regenerative Medicine

Nanomedicine in diagnostics and therapy of cardiovascular diseases: beyond atherosclerotic plaque imaging

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