Construction of Consecutive Chiral Non‐racemic Quaternary and Tertiary Carbon Centers: A Short Synthetic Route to (‐)‐Acetomycin.

Abstract

Diastereoselective syntheses Diastereoselective syntheses O 0031Construction of Consecutive Chiral Non-racemic Quaternary and Tertiary Carbon Centers: A Short Synthetic Route to (-)-Acetomycin. -A highly regioselective and diastereoselectiVe Pd-catalyzed allylic alkylation of optical active allyl acetate (II) is developed for asymmetric construction of quaternary carbon centers and applied to the shortest synthesis of acetomycin (IX) hitherto reported. -(UENISHI*, J.; KAWATSURA, M.; IKEDA, D.; MURAOKA, N.; Eur. J. Org. Chem. 2003, 20, 3909-3912; Kyoto Pharm. Univ., Misasagi, Yamashina, Kyoto 607, Japan; Eng.) -Nuesgen 07-035