Construction of Core-Cross-Linked Polymer Micelles with High Biocompatibility and Stability for pH/Reduction Controllable Drug Delivery

Dual Reduction-Sensitive Nanomicelles for Antitumor Drug Delivery with Low Toxicity to Normal Cells

“…A myriad of chemotherapeutic drugs such as doxorubicin, paclitaxel, and onivyde have been extensively applied in the clinical field, indicating excellent antitumor activity. To enhance drug bioavailability and solubility in water, countless efforts have been made to develop efficacious drug delivery systems. − Due to the desirable advantages, biological stimuli such as enzymes, redox, glucose, pH, and temperature have been commonly applied to the responsive drug release from the drug carriers. − Of these stimuli, reductive sensitivity is especially attractive in the construction of drug delivery systems owing to the different glutathione (GSH) concentrations between the normal body fluids (2–20 μM) and cancer cells (2–20 mM). , Generally, the reduction-responsive nanoparticles were prepared by the introduction of reduction-sensitive linkages or functional groups into their structures. Until now, a series of reduction-responsive nanoparticles including nanogels, micelles, and drug conjugates were used in the preparation of drug delivery systems. − Owing to the promising applications in the delivery of anticancer drugs, nanogels have attracted continuing interest.…”