Abstract:Via
difunctionalization of the α- and β-sites of cyclic
ethers, we herein demonstrate a new synthetic method for the efficient
construction of novel fluorinated γ-amino acid esters by employing
a CoBr2/m-CPBA catalyst system. Several
cyclic ethers were transformed in combination with a vast range of
amines and ethyl trifluoropyruvate into the desired products under
mild conditions, making this method a practical platform to enrich
the library of fluorinated amino acid derivatives from cost-effective
and readil… Show more
A robust metal-free catalytic strategy for the rapid construction of valuable α-Hydroxy-α-CF3-γ-ketoester skeleton with cheap and easily available stock chemicals alkynes and trifluoropyruvate as the starting material is described. This...
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