Construction of gastroretentive aminated chitosan coated (sunflower oil /alginate / i-carrageenan) floatable polymeric beads for prolonged release of Amoxicillin trihydrate

A new approach to oral dosage forms: carrageenan-based vegan gummies

“…According to the Korsmeyer-Peppas model, drug release from the hydrogels is process and diffusion dependent. The obtained gummies were carrageenan-based hydrogel formulations and thus, performed a diffusion and matrix swelling controlled drug release profile as expected ("n" values were found to be between 0.43 and 0.85, that indicated the diffusion and swelling controlled non-Fickian release) [44,45].…”

Fabrication of Antibacterial and Antioxidant ZnO-Impregnated Amine-Functionalized Chitosan Bio-Nanocomposite Membrane for Advanced Biomedical Applications

“…The antibacterial potency of chitosan derivative (i.e., Am-CS) can also be explained by various mechanisms. The most appropriate one for elucidating this activity involves the electrostatic interactions between the positively charged amino groups of Am-CS and the negative charges on the surface of the bacterial cell wall of Gram-negative bacteria [45,46]. This consequently provokes the escape of intracellular ingredients, such as amino acids, proteins, and glucose, due to disrupting the bacterial cell membrane.…”

“…These results could be attributed to the biodegradation nature of the original Am-CS derivative [56]. The formulated bio-nanocomposite membranes have functional hydrophilic amino and hydroxyl groups, which have an affinity for lysozyme adsorption, while the glycosidic bonds would be hydrolyzed, initiating the degradation of the membrane constituents [46,52]. However, the biodegradation rate decreased slightly with the increasing ZnONP content in the membrane matrix.…”

Microspheres Based on Blends of Chitosan Derivatives with Carrageenan as Vitamin Carriers in Cosmeceuticals

“…In vitro biological evaluation showed that the obtained structures demonstrated antimicrobial activity and significant biodegradability under physiological enzymatic conditions, as well as prolonged antibiotic release for up to 25 h without the burst effect. Furthermore, cytotoxicity assessment confirmed the safety of the formulated polymer beads, suggesting their potential use as effective carriers for the oral administration of antibiotics [22]. Stavarache et al (2021) investigated particle production by cross-linking chitosan (CS) with sodium tripolyphosphate (TPP) and the effect of the k-carrageenan (kCG) layer.…”

“…The authors obtained regular shaped and smooth surfaced, non-cytotoxic (in the concentration range from 0.1 to 3 mg/mL) nanocarriers able to control the release of protein for up to 3 weeks [21]. Naiel et al (2023) developed oil-trapped polymer beads based on alginate (Alg)/iota-carrageenan (i-CG) covered with a layer of aminated chitosan (AmCs) for the sustained release of amoxicillin trihydrate (AMT). In vitro biological evaluation showed that the obtained structures demonstrated antimicrobial activity and significant biodegradability under physiological enzymatic conditions, as well as prolonged antibiotic release for up to 25 h without the burst effect.…”