Construction of glucose and H2O2 dual stimuli-responsive polymeric vesicles and their application in controlled drug delivery

Zhou, Junyi; Tang, Qiuju; Zhong, Jiaxing; Lei, Zhentao; Luo, Haipeng; Tong, Zaizai; Jiang, Guohua; Liu, Xiangdong

doi:10.1007/s10853-018-2622-8

Cited by 25 publications

(13 citation statements)

References 50 publications

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“…The synthesis of PEO‐CTA was referred to the previous work (Scheme ) . Typically, DDMAT (3.65 g, 10.0 mmol) and DCM (30.0 mL) were added to a dry 100 mL flask, and oxalyl chloride (COCl) 2 (8.50 mL, 100.0 mmol) dissolved in DCM (20.0 mL) was subsequently added dropwise over 30 min under a nitrogen atmosphere.…”

Section: Methodsmentioning

confidence: 99%

“…Self‐assembly process is of great importance in biological systems for the formation of well‐defined and monodisperse objects on multiple length scales, which is due to their potential applications in biological drug delivery, microreactor chemistry, and in novel nanostructural templating . Specially, amphiphilic neutral block copolymers (BCPs) are of particular interest as they combine compositional diversity and high functionality with various assembly pathways to achieve well‐controlled morphologies .…”

Section: Introductionmentioning

confidence: 99%

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Counterion‐Mediated Self‐Assembly of Ion‐Containing Block Copolymers on the Basis of the Hofmeister Series

Zhong

Luo

Tang

et al. 2019

Macro Chemistry & Physics

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A Cl− and I− ion‐containing amphiphilic diblock copolymer [PEO‐b‐P(qVBC‐co‐St)], IBCP, which comprises the poly(ethylene oxide) block and poly(quaternized 4‐vinylbenzyl chloride‐co‐styrene) is prepared by sequence reactions. Then the counterion‐mediated self‐assembly behavior in aqueous solution is investigated in detail. The hydrophilicity of anion containing units (qVBC) is controlled by the nature of the different counterions after ion exchange, which is crucial in regulating the self‐assembly process. The addition of Br−, I−, and SCN− counterions (based on the Hofmeister series) results in the formation of tighter ion‐pairs with cations (i.e., more hydrophobic as the qVBC units), which triggers spheres to vesicles, micro‐meter long cylinders and “branched wormlike” aggregates, respectively. Moreover, addition of different amounts of Cl− also causes morphological transition from spheres to long cylinders. And this morphological transition is totally reversible after removing additional Cl−. The adhesive collisions of spherical particles may contribute to the observed sphere‐to‐cylinder morphological transition.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Counterion‐Mediated Self‐Assembly of Ion‐Containing Block Copolymers on the Basis of the Hofmeister Series

Zhong

Luo

Tang

et al. 2019

Macro Chemistry & Physics

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“…The self‐assembly of amphiphilic block copolymers (BCPs) in selective solvents is increasingly attracting the attention of researchers in the past decades due to their potential applications in biological drug delivery, microreactor chemistry, and in novel nanostructural templating . In selective solvents, neutral BCPs can form various morphologies such as spheres, cylinders, vesicles, and lamellae, which can be regulated by many factors, such as block length, solvent composition, pH, and inorganic salt .…”

Section: Introductionmentioning

confidence: 99%

Interplay of Solvation and Size Effects Induced by the Counterions in Ionic Block Copolymers on the Basis of Hofmeister Series

Luo

Tang

Zhong

et al. 2019

Macro Chemistry & Physics

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Two ionic block copolymers with different lengths of hydrophilic segments, polystyrene‐b‐poly(quaternized 4‐vinylpyridine)/ethyl bromide, are prepared by sequential reactions. They are originally self‐assembled into so‐called “large compound micelles” in aqueous solution. After ion exchange of Iˉ, SCN,ˉ and PF6ˉ for Brˉ, morphological transitions are controlled by a competition of solvation and size effects of the newly introduced counterions. The solvation effect is dominated in a relatively short corona‐forming block. Thus, sphere‐to‐wormlike particles, sphere‐to‐vesicle, and sphere‐to‐precipitate transitions are observed. In contrast, due to a long corona‐forming block, size effects become more profound after adding SCNˉ, thereby no morphological transition occurs. A morphological transition is characterized after partial exchange of Iˉ for Brˉ for both diblocks. A sphere‐to‐wormlike particles transition is observed only after most Brˉ is replaced by Iˉ. This work extends the understanding of morphological regulation through simple ion exchange and encourages rational design of nano‐assemblies.

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“…These systems can maintain precise control over drug concentration within the therapeutic window [8,9]. Also, controlled drug delivery has * E-mail: eakyol@yildiz.edu.tr a robust structure and large loading capacity of hydrophilic drugs [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of pH-sensitive hydrogels from photo-crosslinked poly(ethylene glycol) diacrylate incorporating titanium dioxide

Şenol

Akyol

2020

Materials Science-Poland

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The purpose of the present investigation was to prepare pH-sensitive hydrogels from photo-crosslinked poly(ethylene glycol) diacrylate (PEG-DA). Rutile titanium dioxide (TiO2) was employed to modify the PEG-DA hydrogels. The rutile titanium dioxide (TiO2) nanoparticles were prepared by direct oxidation of titanium in the presence of polyethylene glycol (PEG) at high temperature. The nanoparticles were characterized by FT-IR, XRD and SEM. The influence of experimental conditions, such as pH, type and amount of photoinitiators on the release profiles of donepezil hydrochloride (active pharmaceutical ingredient for Alzheimer disease) from modified PEG-DA hydrogels, was investigated. The drug release processes were analyzed kinetically using zero-order, first-order, Hixson-Crowell and Peppas models.

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Construction of glucose and H2O2 dual stimuli-responsive polymeric vesicles and their application in controlled drug delivery

Cited by 25 publications

References 50 publications

Counterion‐Mediated Self‐Assembly of Ion‐Containing Block Copolymers on the Basis of the Hofmeister Series

Counterion‐Mediated Self‐Assembly of Ion‐Containing Block Copolymers on the Basis of the Hofmeister Series

Interplay of Solvation and Size Effects Induced by the Counterions in Ionic Block Copolymers on the Basis of Hofmeister Series

Preparation and characterization of pH-sensitive hydrogels from photo-crosslinked poly(ethylene glycol) diacrylate incorporating titanium dioxide

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