Construction of healthy arteries using computed tomography and virtual histology intravascular ultrasound

Ryou, Hong Sun; Kim, Seungwook; Kim, Sang Wook; Seong, In Whan

doi:10.1016/j.jbiomech.2012.04.003

Cited by 18 publications

(11 citation statements)

References 32 publications

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“…The assumption of Newtonian fluid for the blood is valid wherever the shear rate is greater than 100 S −1 [19,26,32,33,41]. This assumption is feasible for thoracic aorta and three major branches.…”

Section: Governing Equations and Boundary Conditionsmentioning

confidence: 99%

Effects of severity and location of stenosis on the hemodynamics in human aorta and its branches

Dabagh

Vasava

Jalali

2015

Med Biol Eng Comput

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Pulsatile blood flow is studied in a three-dimensional model of human thoracic aorta at different stages of atherosclerotic lesion growth, taking into account the effect of atherosclerotic plaque location and peripheral symmetry. The model is reconstructed from the computed tomography images. The wall shear stress (WSS), time-averaged WSS, and the oscillatory shear index are applied to determine susceptible sites for the onset of early atherosclerosis. Then, two different degrees of stenosis severity, 50 and 80 %, are introduced to vulnerable areas of the healthy aorta geometry. The overriding issue addressed is that the WSS distribution and magnitude are strongly affected by the atherosclerotic plaque size, its symmetric features, and the location, i.e., the branch it is formed. The present study, for the first time, is capable of providing information on the high shear environment that may exist upon the rupture of plaque surface and any thrombosis due to platelet deposition. The magnitude of WSS and its distribution at the throat of 50 % stenosed aortic arch are in agreement with the previous numerical study (Huang et al. in Exp Fluids 48(3):497-508, 2010). Results show that WSS values exceed 50 Pa at the throat of 80 % stenosed left common carotid and brachiocephalic arteries.

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Section: Governing Equations and Boundary Conditionsmentioning

confidence: 99%

Effects of severity and location of stenosis on the hemodynamics in human aorta and its branches

Dabagh

Vasava

Jalali

2015

Med Biol Eng Comput

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“…Oscillatory shear index (OSI) which is another WSS based hemodynamics parameter is used as a predictor for the atherosclerosis plaque formation and susceptibility of plaque in coronary arteries (Zhang et al 2008;Ryou et al 2012). High OSI value is strongly related to the development of atherosclerosis since it affects the endothelial cells arrangement in adjacent tissues.…”

Section: Introductionmentioning

confidence: 99%

“…High OSI value is strongly related to the development of atherosclerosis since it affects the endothelial cells arrangement in adjacent tissues. Also, high OSI value regions are generally located in the low WSS regions [Stadler et al 1990;Ryou et al 2012].…”

Section: Introductionmentioning

confidence: 99%

Effect of Stenosis Severity on Wall Shear Stress Based Hemodynamic Descriptors using Multiphase Mixture Theory

Buradi

Mahalingam

2018

JAFM

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A variety of wall shear stress (WSS) based hemodynamic descriptors have been defined over the years to study hemodynamic flow instabilities as potential indicators or prognosticators of endothelial wall dysfunction. Generally, these hemodynamic indicators have been calculated numerically using 'single phase' approach. In single phase models, the flow-dependent cell interactions and their transport are usually neglected by treating blood as a single phase non-Newtonian fluid. In the present investigation, a multiphase mixture-theory model is used to define the motion of red blood cells (RBCs) in blood plasma and interactions between these two-components. The multiphase mixture theory model exhibited good agreement with the experimental results and performed better than non-Newtonian single phase model. The mixture-theory model is then applied to simulate pulsatile blood flow through four idealized coronary artery models having different degrees of stenosis (DOS) severities viz., 30, 50, 70 and 85% diameter reduction stenosis. The maximum WSS is seen at the stenosis throat in all the cases and maximum oscillatory shear index (OSI) is seen in downstream region of the stenosis. Our findings suggest that for degree of coronary stenosis more than 50%, a more disturbed fluid dynamics is observed downstream of stenosis. This could lead to further progression of stenosis and may promote a higher risk of atherogenesis and plaque buildup in the flow-disturbed area. The potential atherosclerotic lesion sites were identified based on clinically relevant values of WSS, timeaveraged WSS gradient (TAWSSG), time-averaged WSS (TAWSS), and OSI. Finally, the change in potential atherosclerotic lesion sites with respect to DOS has been quantified.

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“…75 For the viscosity, the question of non-Newtonian effects has been raised, 76,77 and a Carreau viscosity model [78][79][80][81] or a power-law model 82 are often preferred to treat non-Newtonian effects in large arteries. In Liu et al, 81 the authors indicate that the non-Newtonian effects can be significant in the study of mass transport, in particular in the atherogenic-prone areas where luminal surface LDL concentration is high.…”

Section: Fluid Physical Propertiesmentioning

confidence: 99%

Evolution and rupture of vulnerable plaques: a review of mechanical effects

Assemat¹,

Hourigan²

2013

CPT

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Atherosclerosis occurs as a result of the buildup and infiltration of lipid streaks in artery walls, leading to plaques. Understanding the development of atherosclerosis and plaque vulnerability is of critical importance, since plaque rupture can result in heart attack or stroke. Plaques can be divided into two distinct types: those that rupture (vulnerable) and those that are less likely to rupture (stable). In the last few decades, researchers have been interested in studying the influence of the mechanical effects (blood shear stress, pressure forces, and structural stress) on the plaque formation and rupture processes. In the literature, physiological experimental studies are limited by the complexity of in vivo experiments to study such effects, whereas the numerical approach often uses simplified models compared with realistic conditions, so that no general agreement of the mechanisms responsible for plaque formation has yet been reached. In addition, in a large number of cases, the presence of plaques in arteries is asymptomatic. The prediction of plaque rupture remains a complex question to elucidate, not only because of the interaction of numerous phenomena involved in this process (biological, chemical, and mechanical) but also because of the large time scale on which plaques develop. The purpose of the present article is to review the current mechanical models used to describe the blood flow in arteries in the presence of plaques, as well as reviewing the literature treating the influence of mechanical effects on plaque formation, development, and rupture. Finally, some directions of research, including those being undertaken by the authors, are described.

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Construction of healthy arteries using computed tomography and virtual histology intravascular ultrasound

Cited by 18 publications

References 32 publications

Effects of severity and location of stenosis on the hemodynamics in human aorta and its branches

Effects of severity and location of stenosis on the hemodynamics in human aorta and its branches

Effect of Stenosis Severity on Wall Shear Stress Based Hemodynamic Descriptors using Multiphase Mixture Theory

Evolution and rupture of vulnerable plaques: a review of mechanical effects

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