Construction of high quality ultrathin lanthanide oxyiodide nanosheets for enhanced CT imaging and anticancer drug delivery to efficient cancer theranostics

Xu, Lingling; Xue, Yumeng; Qu, Xiaoyan; Lei, Bo; Tian, Yang; Zhang, Xiaozhi; Li, Na; Zhao, Hongyang; Wang, Min; Luo, Meng; Zhang, Chao; Du, Yaping; Yan, Chun‐Hua

doi:10.1016/j.biomaterials.2019.119670

Cited by 36 publications

(19 citation statements)

References 44 publications

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“…In this study, a combination of X‐ray imaging/ultrasonography/computed tomography (CT) and histopathology was used to diagnose tumours 24‐26 . The samples were obtained from 42 tumour‐bearing dogs with suspected mammary tumour, including 30 (62.5%) CMTs and 12 (37.5%) skin cancers.…”

Section: Resultsmentioning

confidence: 99%

miR‐497 induces apoptosis by the IRAK2/NF‐κB axis in the canine mammary tumour

Zhang

XiuJuan

Zhou

et al. 2020

Vet Comparative Oncology

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Since companion dogs have the same living environment as humans, they are a good animal model for the study of human diseases; this is especially true of canine spontaneous mammary tumours models. A better understanding of the natural history and molecular mechanisms of canine mammary tumour is of great significance in comparative medicine. Here, we collected canine mammary tumour cases and then assayed the clinical cases by pathological examination and classification by HE staining and IHC. miRNA‐497 family members (miR‐497, miR‐16, miR‐195 and miR‐15) were positively correlated with the breast cancer marker genes p63 and PTEN. Modulation of the expression of miR‐497 in the canine mammary tumour cell lines CMT1211 and CMT 7364 induced apoptosis and inhibited cell proliferation. Mechanistically, IRAK2 was shown to be a functional target of miR‐497 that affects the characteristics of cancer cells by inhibiting the activity of the NF‐κB pathway. Overall, our work reveals the miR‐497/IRAK2/NF‐κB axis as a vital mechanism of canine mammary tumour progression and suggests this axis as a target in breast cancer.

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Section: Resultsmentioning

confidence: 99%

miR‐497 induces apoptosis by the IRAK2/NF‐κB axis in the canine mammary tumour

Zhang

XiuJuan

Zhou

et al. 2020

Vet Comparative Oncology

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“…[ 15–17 ] Moreover, these nanosystems that could provide high 3D resolution and sensitive imaging signals [e.g., X‐ray computed tomography (CT) imaging, photoacoustic (PA) imaging], and generate hyperthermia effect (temperature of higher than 42 °C) triggered by NIR‐II laser, are the desirable candidate theranostic nanoplatforms for bioimaging‐guided photonic hyperthermia. [ 18–22 ]…”

Section: Introductionmentioning

confidence: 99%

“…and sensitive imaging signals [e.g., X-ray computed tomography (CT) imaging, photoacoustic (PA) imaging], and generate hyperthermia effect (temperature of higher than 42 °C) triggered by NIR-II laser, are the desirable candidate theranostic nanoplatforms for bioimaging-guided photonic hyperthermia. [18][19][20][21][22] Previous exploration on theranostic nanosystems with both photothermal-conversion and bioimaging functions dominantly concentrated on noble-metal, [23][24][25][26] transition metal chalcogenide, [27][28][29] nanocarbons, [30,31] 2D, [32][33][34] and organic-conjugated polymeric nanosystems. [35][36][37] To date, however, owing to laborious synthesis methods, low NIR-II light absorption, and large size, the theranostic nanosystems exhibit desirable photonic hyperthermia at NIR-II biowindow are still rare, [38][39][40] which are mainly limited to several nanosystems.…”

Section: Introductionmentioning

confidence: 99%

Degradable and Excretable Ultrasmall Transition Metal Selenide Nanodots for High‐Performance Computed Tomography Bioimaging‐Guided Photonic Tumor Nanomedicine in NIR‐II Biowindow

Dong

Sun

et al. 2021

Adv Funct Materials

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Transition metal selenide nanodots (NDs) represent distinctive antitumor agents for cancer treatment, but their non‐biodegradability may bring serious adverse effects and potential long‐term toxicity to internal tissues/organs, which substantially hinder their further clinical translations. In this work, the construction of a multifunctional theranostic nanosystem based on degradable and excretable ultrasmall Rh3Se8 NDs by a general bovine serum albumin‐templated strategy is reported. The constructed Rh3Se8 NDs exhibit distinctively high photothermal‐conversion efficiency (57.5%) in the second near‐infrared biowindow, making them highly applicable for photoacoustic imaging and photonic hyperthermia at the desired wavelength. Rh3Se8 NDs exhibit a high tumor growth inhibition rate (98.1%) on 4T1 breast tumor‐bearing mice due to the desirable photonic hyperthermia performances. Especially, the fabricated Rh3Se8 NDs feature the large X‐ray attenuation coefficients of the Rh component for contrast‐enhanced X‐ray computed tomography imaging. Importantly, the prominent biodegradability of Rh3Se8 NDs enables their quick excretion out of the body for potentially avoiding inflammation and mitigating long‐term toxicity. Therefore, this work highlights the construction of proof‐of‐concept biodegradable and excretable ultrasmall inorganic theranostic nanosystems for multiple bioimaging‐guided cancer nanotherapeutics, guaranteeing the further clinical translations of inorganic nanoparticles in biomedicine.

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“…along with therapeutic molecule (e. g. drugs, proteins, genes etc.). Many nanomaterials‐based theranostic agents such as metallic [1,2] (e. g. gold, silver), [2] inorganic (e. g. iron oxide, lanthanide ion doped nanoparticles), [3–11] polymeric [12] (e. g. polylactone, [13] carboxylated poly [styrene‐co‐chloromethyl styrene]‐graft‐poly ethylene glycol [14] ), carbon‐based (e. g. graphene, carbon nanotubes, carbon dot), [15,16] aggregation‐induced emission (AIE) dots [17,18] and mesoporous (e. g. mesoporous silica, mesoporous glasses) [19–21] nanomaterials have been explored. Among the above, materials possessing fluorescence as a diagnosis probe is popular since fluorescence imaging provides high sensitivity and can also be used for molecular imaging [22] .…”

Section: Introductionmentioning

confidence: 99%

“…We note that many lanthanide‐doped nanomaterials have been largely exploited as bioimaging agent but not as theranostic agents [24,25] . In this regard, few lanthanide‐based nanoparticles are explored as theranostic vehicles, for example, core‐shell structured NaLuF 4 nanorods@polydopamine, [5] Gd/Eu‐doped ZnO NPs, [6] lanthanum oxyiodide (LaOI) nanosheets, [8] polyacrylic acid (PAA)‐functionalized porous BiF 3 :Yb,Er, [9] NaLnF 4 @MOF−Ln nanocomposites, [10] zwitterionic gadolinium(III) (Gd(III))‐complexed dendrimer‐entrapped gold nanoparticles, [11] etc. Though the above reports show promising results, most of the studies are in the preliminary level and they face the following challenges:(1) do not possess targeting ability, (2) limited drug loading, (3) extensive surface chemistry to conjugate the drug, which can affect the photoluminescence properties, (4) lack of information regarding in vitro, immuno‐compatibility and in vivo toxicity, (5) lack of information regarding bio‐distribution and targeting efficiency and (6) use of high concentration for in vivo imaging.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Multifunctional Theranostic Nanoprobe for Imaging and Chemotherapy in Solid‐Tumor‐Bearing Mice

et al. 2020

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Theranostic carriers are widely studied as they can be exploited for both imaging and drug delivery. However, although there are reports suggesting their in vitro level imaging and drug release, there is necessity to display the application (drug delivery/bioimaging/toxicity) at an in vivo level, which is a pre‐requisite for clinical use. Herein, we demonstrate targeted in vivo imaging and biodistribution in Swiss Albino mice solid tumor model using PEGylated polymer capsules encapsulating LaVO4 : Tb3+ nanoparticles (concentration of nanoparticles ∼3.4 μM LaVO4/kg body weight). The capsules were further loaded with doxorubicin for drug delivery which shows tumor regression at different time intervals in tumor mice model. We have further investigated the tumor marker enzymes including β‐glucuronidase, myeloperoxidase, lactate dehydrogenase, and alkaline phosphatase which clearly suggest the reversion to near normal levels after treating with doxorubicin‐loaded polymer capsules for 30 days. comet assay shows DNA damage in tumor cells induced by doxorubicin. Histology studies performed in tumor tissue and liver show obliteration of tumor cells after treating with doxorubicin‐loaded PEGylated polymer capsules encapsulating LaVO4 : Tb3+ nanoparticles. It has also been observed that the weight of the spleen which was enlarged in solid‐tumor‐bearing mice is significantly lower in animals treated with drug‐loaded capsules.

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Construction of high quality ultrathin lanthanide oxyiodide nanosheets for enhanced CT imaging and anticancer drug delivery to efficient cancer theranostics

Cited by 36 publications

References 44 publications

miR‐497 induces apoptosis by the IRAK2/NF‐κB axis in the canine mammary tumour

miR‐497 induces apoptosis by the IRAK2/NF‐κB axis in the canine mammary tumour

Degradable and Excretable Ultrasmall Transition Metal Selenide Nanodots for High‐Performance Computed Tomography Bioimaging‐Guided Photonic Tumor Nanomedicine in NIR‐II Biowindow

Biocompatible Multifunctional Theranostic Nanoprobe for Imaging and Chemotherapy in Solid‐Tumor‐Bearing Mice

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