Construction of hydrogen bonding and coordination networks based on ethynylpyridine-appended nucleobases

Abstract

A series of ethynylpyridine-appended nucleobases have been designed, synthesized, characterized and employed for the formation of crystalline molecular networks by hydrogen/coordination bonding.

Platinum-Nucleos(t)ide Compounds as Possible Antimetabolites for Antitumor/Antiviral Therapy: Properties and Perspectives

“…They can act as prodrugs and, once introduced inside cells by the plasma membrane nucleoside transporters, require intracellular phosphorylation to generate their pharmacologically active triphosphate form [ 38 ]. Many investigations have focused on the study of the synthesis, structural features, and antitumor and/or antiviral biological effects of platinated nucleotides [ 74 , 79 , 89 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 ]. Recently, our research efforts were devoted to a deeper comprehension of the cellular metabolic mechanisms involving some model platinated nucleos(t)ides, to confirm their potential as antimetabolites.…”

Beyond Sole Models for the First Steps of Pt-Dna Interactions: Fundamental Properties of Mono(Nucleobase) Adducts of Ptii Coordination Compounds

“…We have previously elaborated on different aspects of this topic with a focus on unsubstituted pyrimidine nucleobases [17][18][19]. Similarly, if nucleobase-ligand conjugates are employed, and/or metals other than the d 8 metal ions discussed here preferentially, are included, fascinating constructs are emerging, leading into the realms of supramolecular chemistry, crystal engineering, and materials research [20][21][22][23][24][25][26][27][28][29][30][31][32]. We explicitly do not wish to embark here on nucleic acid-based nanotechnology, a field that develops at an astonishing rate [33].…”