Construction of Inflatable Lungs to Simulate Respiratory Motion in Myocardial Perfusion Imaging

Lontos, Antonis; Antoniou, A.; Chrysanthou, Isabelle; Christofides, Stelios; Demetriadou, Ourania; Panagidis, Chr.; Yiannakkaras, Ch; Kaolis, Demetris; Parpottas, Yiannis

doi:10.1007/978-3-319-32703-7_257

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…The CT images at the endpoints of the dynamic respiratory phases, in normal and deep breathing, were utilised to measure with the OsiriX software package the volume of the lungs and the downward displacement of the thoracic phantoms. A 2% maximum deviation was calculated between the measured volumes and the calculated values of Table 1 , as in refs [ 11 , 12 ]. For the downward displacements, a 1.7% maximum deviation was calculated between the measured and the calculated values of Table 1 .…”

Section: Resultsmentioning

confidence: 99%

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A moving liver phantom in an anthropomorphic thorax for SPECT MP imaging

et al. 2022

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Cranio-caudal respiratory motion and liver activity cause a variety of complex myocardial perfusion (MP) artifacts, especially in the inferior myocardial wall, that may also mask cardiac defects. To assess and characterise such artifacts, an anthropomorphic thorax with moving thoracic phantoms can be utilised in SPECT MP imaging. In this study, a liver phantom was developed and anatomically added into an anthropomorphic phantom that also encloses an ECG beating cardiac phantom and breathing lungs’ phantom. A cranio-caudal respiratory motion was also developed for the liver phantom and it was synchronised with the corresponding ones of the other thoracic phantoms. This continuous motion was further divided into isochronous dynamic respiratory phases, from end-exhalation to end-inspiration, to perform SPECT acquisitions in different respiratory phases. The new motions’ parameters and settings were measured by mechanical means and also validated in a clinical environment by acquiring CT images and by using two imaging software packages. To demonstrate the new imaging capabilities of the phantom assembly, SPECT/CT MP acquisitions were performed and compared to previous phantom and patients studies. All thoracic phantoms can precisely perform physiological motions within the anthropomorphic thorax. The new capabilities of the phantom assembly allow to perform SPECT/CT MP acquisitions for different cardiac-liver activity ratios and cardiac-liver proximities in supine and, for first time, in prone position. Thus, MP artifacts can be characterised and motion correction can be performed due to these new capabilities. The impact of artifacts and motion correction on defect detection can be also investigated.

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Section: Resultsmentioning

confidence: 99%

“…The tidal volume in the lungs at any time during the mode of dynamic respiratory phases was measured with a dedicated custom-made structure [ 11 ]. The lungs were immersed and held within a fully filled water tank.…”

Section: Methodsmentioning

confidence: 99%

A moving liver phantom in an anthropomorphic thorax for SPECT MP imaging

et al. 2022

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“…In our previous studies [2,3,[10][11][12], we acquired SPECT/CT images using an anthropomorphic thorax which enclosed moving thoracic compartments: (a) a cardiac phantom of an ECG beating and moving left ventricle during respiration in the cranio-caudal direction, and (b) a breathing phantom of a pair of lungs. These motions could be controlled in time interval of 0.1 sec and various parameters of the motions can vary such as the ejection fraction, heart rate, breath rate and tidal volume.…”

Section: Introductionmentioning

confidence: 99%

A Moving Liver Phantom in An Anthropomorphic Thorax for SPECT MP Imaging

Panagi¹,

Hadjiconstanti²,

Charitou³

et al. 2021

Preprint

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Cranio-caudal respiratory motion and liver activity cause a variety of complex myocardial perfusion (MP) artifacts, especially in the inferior myocardial wall, that may also mask cardiac defects. To assess and characterize such artifacts, an anthropomorphic thorax with moving thoracic phantoms can be utilized in SPECT MP imaging. In this study, a liver phantom was developed, and anatomically added into an anthropomorphic phantom, that encloses an ECG beating cardiac phantom and breathing lungs phantom. A cranio-caudal respiratory motion was also developed for the liver phantom and it was synchronized with the corresponding ones of the cardiac and lungs phantoms. This continuous motion could also be further divided into dynamic respiratory phases, from end-exhalation to end-inspiration, to perform SPECT acquisitions in different respiratory phases. The motion parameters, displacements and volumes, were validated by the acquired CT slices, the OsiriX and Vitrea software. Sample SPECT/16-slice-CT myocardial MP acquisitions were also performed and compared to the literature. The cardiac, lungs and liver phantoms can precisely perform, in time interval of 0.1 sec, physiological thoracic motions within an anthropomorphic thorax. This dynamic phantom assembly can be utilized for SPECT MP supine and, for first time, prone imaging to access and characterize artifacts due to different cranio-caudal respiratory amplitudes and cardiac-liver activity ratios.

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“…Medical devices differ from other medical interventions, such as pharmaceuticals [10,4,11]. In terms of effectiveness, medical devices may change their effectiveness through time due to modifications, they are user-dependent and have a "learning curve", which depends on the technology uptake [12]. Also, the effectiveness of the diagnostics depend on subsequent treatment and the medical devices may be used for different medical conditions in different settings -with different effectiveness.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Devices, Diagnostics and Digital Technologies: A Review of NICE Medical Technologies Guidance

Crispi

Naci

Barkauskaite

et al. 2018

Appl Health Econ Health Policy

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Background: The Medical Technologies Evaluation Programme (MTEP) of NICE in England aims to evaluate medical devices that are deemed to be cost-saving or cost-neutral and produce medical technology guidance (MTG) to encourage their adoption. Objective: To review the MTGs since MTEP's inception in 2009 until February 2017. Methods: One researcher assessed all published MTGs and extracted data on the clinical and economic evidence supporting each technology. The NICE Committee's decision outcome for each assessment was also recorded. A qualitative analysis was performed on technologies that were not supported for adoption to identify the main drivers of the decision. Results: 31 MTGs were reviewed. The committee fully supported the medical devices in 14 MTGs, 11 were partially supported and 6 not-supported. 58% of the MTGs had no RCT data available and the main source of evidence came from non-experimental studies. There was no statistically significant difference in the average number of RCTs and non-experimental studies between the fully supported, partially supported and not supported technologies. Whilst all the fully supported MTGs demonstrated cost-saving results only 50% of the not-supported MTGs did. The sponsor estimated a higher average cost-saving than the EAC in most of cases (20/31). The qualitative evaluation suggests that the main drivers for negative decisions were the quantity or quality of studies, and cost incurring results in the economic evaluation. Conclusions: The main drivers of the decision-making process are the quality and quantity of the submitted evidence supporting the technologies, as well as the economic evaluation results.

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Construction of Inflatable Lungs to Simulate Respiratory Motion in Myocardial Perfusion Imaging

Cited by 4 publications

References 8 publications

A moving liver phantom in an anthropomorphic thorax for SPECT MP imaging

A moving liver phantom in an anthropomorphic thorax for SPECT MP imaging

A Moving Liver Phantom in An Anthropomorphic Thorax for SPECT MP Imaging

Assessment of Devices, Diagnostics and Digital Technologies: A Review of NICE Medical Technologies Guidance

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