Construction of lysozyme exfoliated rectorite‐based electrospun nanofibrous membranes for bacterial inhibition

Zhan, Yingfei; Zeng, Wen; Jiang, Guoxia; Wang, Qun; Shi, Xiaowen; Zhou, Zhehao; Deng, Hongbing; Du, Yumin

doi:10.1002/app.41496

Cited by 63 publications

(20 citation statements)

References 43 publications

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“…The use of metallic and metallic oxide nanoparticles (NPs) in areas of biotechnology, biosensors, bioimaging, and drug delivery applications has become increasingly popular . Various therapeutic applications, such as in the treatment of inflammatory and infectious diseases, as well as biomedical applications, particularly in the construction of NP‐based hydrogels, mats, and membranes, have recently been well established. Their unique physicochemical properties such as increased surface‐area‐to‐volume ratio, controllable shape and size, superparamagnetism, and exhibiting quantum confinement effects allow them to possess remarkable features in terms of conductivity, optical sensitivity, and reactivity .…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress by inorganic nanoparticles

Tee

Ong

Bay

et al. 2015

WIREs Nanomed Nanobiotechnol

103

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Metallic and metallic oxide nanoparticles (NPs) have been increasingly used for various bio-applications owing to their unique physiochemical properties in terms of conductivity, optical sensitivity, and reactivity. With the extensive usage of NPs, increased human exposure may cause oxidative stress and lead to undesirable health consequences. To date, various endogenous and exogenous sources of oxidants contributing to oxidative stress have been widely reported. Oxidative stress is generally defined as an imbalance between the production of oxidants and the activity of antioxidants, but it is often misrepresented as a single type of cellular stress. At the biological level, NPs can initiate oxidative stress directly or indirectly through various mechanisms, leading to profound effects ranging from the molecular to the disease level. Such effects of oxidative stress have been implicated owing to their small size and high biopersistence. On the other hand, cellular antioxidants help to counteract oxidative stress and protect the cells from further damage. While oxidative stress is commonly known to exert negative biological effects, measured and intentional use of NPs to induce oxidative stress may provide desirable effects to either stimulate cell growth or promote cell death. Hence, NP-induced oxidative stress can be viewed from a wide paradigm. Because oxidative stress is comprised of a wide array of factors, it is also important to use appropriate assays and methods to detect different pro-oxidant and antioxidant species at molecular and disease levels. WIREs Nanomed Nanobiotechnol 2016, 8:414-438. doi: 10.1002/wnan.1374 For further resources related to this article, please visit the WIREs website.

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Section: Introductionmentioning

confidence: 99%

Oxidative stress by inorganic nanoparticles

Tee

Ong

Bay

et al. 2015

WIREs Nanomed Nanobiotechnol

103

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“…QAC are perfectly suitable for disinfection; however, their toxicity may hamper their use in vivo . Several nanomaterials based on polyelectrolytes and their nanocomposites have been developed for antibacterial applications [ 18 , 19 , 20 ]. The cationic polymer, poly (diallyldimethylammonium) chloride (PDDA), with pendant quaternary nitrogen groups, does not cause hemolysis [ 16 ] and can easily be formulated as the outer layer of self-assembled nanoparticles (NPs) [ 16 , 17 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Cationic Assemblies against Multidrug-Resistant Microorganisms: Activity and Mechanism of Action

Carrasco

Sampaio

Carmona-Ribeiro

2015

IJMS

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The growing challenge of antimicrobial resistance to antibiotics requires novel synthetic drugs or new formulations for old drugs. Here, cationic nanostructured particles (NPs) self-assembled from cationic bilayer fragments and polyelectrolytes are tested against four multidrug-resistant (MDR) strains of clinical importance. The non-hemolytic poly(diallyldimethylammonium) chloride (PDDA) polymer as the outer NP layer shows a remarkable activity against these organisms. The mechanism of cell death involves bacterial membrane lysis as determined from the leakage of inner phosphorylated compounds and possibly disassembly of the NP with the appearance of multilayered fibers made of the NP components and the biopolymers withdrawn from the cell wall. The NPs display broad-spectrum activity against MDR microorganisms, including Gram-negative and Gram-positive bacteria and yeast.

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“…Nanoparticles have gained wide interest due to their characteristics including high capacity for drug loading, lower or no systematic toxicity, physical and chemical stability, pharmaceutical improvement of drug properties, and drug permeabilization. (21)(22)(23)(24)(25)(26)(27) However, the penetration of the nanoparticles through the BBB highly depends on the type, size, surface chemistry, and polarity of the particles. (28) This review discusses the application of drug-loaded nanocarriers in the treatment of neurodegenerative diseases.…”

Section: Figure 1 Overall Scope Of Neurodegenerative Diseasesmentioning

confidence: 99%

Treatment of neurodegenerative disorders through the blood–brain barrier using nanocarriers

et al. 2018

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Neurodegenerative diseases refer to disorders of the central nervous system (CNS) that are caused by neuronal degradations, dysfunctions, or death. Alzheimer's disease, Parkinson's disease, and Huntington's disease (APHD) are regarded as the three major neurodegenerative diseases. There is a vast body of literature on the causes and treatments of these neurodegenerative diseases. However, the main obstacle in developing an effective treatment strategy is the permeability of the treatment components at the blood-brain barrier (BBB). Several strategies have been developed to improve this obstruction. For example, nanomaterials facilitate drug delivery to the BBB due to their size. They have been used widely in nanomedicine and as nanoprobes for diagnosis purposes among others in neuroscience. Nanomaterials in different forms, such as nanoparticles, nanoemulsions, solid lipid nanoparticles (SLN), and liposomes, have been used to treat neurodegenerative diseases. This review will cover the basic concepts and applications of nanomaterials in the therapy of APHD.

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Construction of lysozyme exfoliated rectorite‐based electrospun nanofibrous membranes for bacterial inhibition

Cited by 63 publications

References 43 publications

Oxidative stress by inorganic nanoparticles

Oxidative stress by inorganic nanoparticles

Supramolecular Cationic Assemblies against Multidrug-Resistant Microorganisms: Activity and Mechanism of Action

Treatment of neurodegenerative disorders through the blood–brain barrier using nanocarriers

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