Construction of MPDA@IR780 nano drug carriers and photothermal therapy of tumor cells

Lin, Lanlan; Li, Haiyang; Chen, Zekun; Wen, Xian; Yan, Rui; Liu, Lei; Tao, Caihong

doi:10.1016/j.jddst.2022.103819

Cited by 2 publications

(1 citation statement)

References 47 publications

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“…Recently, the development of environmentally responsive nanocapsules has taken a new direction in addressing this problem. Drugs were loaded in nanocarriers that respond to the body's specific environment to overcome the difficulty of delivering drugs to targeted cells [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Zwitterionic nanocapsules with pH- and thermal- responsiveness for drug-controlled release

Sun¹,

Yang²,

Xu³

et al. 2023

Nanotechnology

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The construction of an environmentally responsive drug-release system is of great significance for the treatment of special diseases. In particular, the construction of nanomaterials with pH- and thermal-responsiveness, which can effectively encapsulate drugs and control drug release, is becoming hot research. In this study, zwitterionic nanocapsules (ZNCs) with stable core-shell structures were synthesized by inverse reversible addition-fragmentation transfer (RAFT) miniemulsion interfacial polymerization. To further study the structure and performance of the nanocapsules, the prepared nanocapsules were characterized by transmission electron microscopy (TEM), dynamic light dispersion (DLS), and zeta potential analysis. It was found that the nanocapsules had dual pH- and thermal- responsiveness, and the average particle size ranged from 178 nm to 142 nm when the temperature changed from 25 ℃ to 40 ℃. In addition, bovine serum albumin (BSA) was encapsulated into nanocapsules, and sustained release experiments were conducted at 10 ℃ and 40 ℃. The results showed that nanocapsules as carriers of BSA could achieve the purpose of sustained release of drugs, and showed different sustained release curves at different temperatures. Finally, in vitro cytotoxicity tests were performed to demonstrate the feasibility of their biomedical application. It is believed that the dual pH- and thermal- responsive nanocapsules are promising for drug-controlled release.

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Section: Introductionmentioning

confidence: 99%

Zwitterionic nanocapsules with pH- and thermal- responsiveness for drug-controlled release

Sun¹,

Yang²,

Xu³

et al. 2023

Nanotechnology

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Multiple Treatment of Triple‐Negative Breast Cancer Through Gambogic Acid‐Loaded Mesoporous Polydopamine

Liu,

Huang

et al. 2024

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Triple‐negative breast cancer (TNBC) is a highly heterogeneous subtype of breast cancer, characterized by aggressiveness and high recurrence rate. As monotherapy provides limited benefit to TNBC patients, combination therapy emerges as a promising treatment approach. Gambogic acid (GA) is an exceedingly promising anticancer agent. Nonetheless, its application potential is hampered by low drug loading efficiency and associated toxic side effects. To overcome these limitations, using mesoporous polydopamine (MPDA) endowed with photothermal conversion capabilities is considered as a delivery vehicle for GA. Meanwhile, GA can inhibit the activity of heat shock protein 90 (HSP90) to enhance the photothermal effect. Herein, GA‐loaded MPDA nanoparticles (GA@MPDA NPs) are developed with a high drug loading rate of 75.96% and remarkable photothermal conversion performance. GA@MPDA NPs combined with photothermal treatment (PTT) significantly inhibit the tumor growth, and effectively trigger the immunogenic cell death (ICD), which thereby increase the number of activated effector T cells (CD8+ T cells and CD4+ T cells) in the tumor, and hoist the level of immune‐inflammatory cytokines (IFN‐γ, IL‐6, and TNF‐α). The above results suggest that the combination of GA@MPDA NPs with PTT expected to activate the antitumor immune response, thus potentially enhancing the clinical therapeutic effect on TNBC.

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Construction of MPDA@IR780 nano drug carriers and photothermal therapy of tumor cells

Cited by 2 publications

References 47 publications

Zwitterionic nanocapsules with pH- and thermal- responsiveness for drug-controlled release

Zwitterionic nanocapsules with pH- and thermal- responsiveness for drug-controlled release

Multiple Treatment of Triple‐Negative Breast Cancer Through Gambogic Acid‐Loaded Mesoporous Polydopamine

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