Construction of nano slow-release systems for antibacterial active substances and its applications: A comprehensive review

Abstract

At present, nano-carrier materials with antibacterial activity are of great significance. Due to the widespread resistance of many pathogenic microorganisms, it has seriously threatened human health. The natural antimicrobial substances extracted from fruits and vegetables can significantly improve their stability combined with nano-carrier materials. The resistance of pathogenic microorganisms will be substantially reduced, greatly enhancing the effect of active antimicrobial substances. Nanotechnology has excellent research prospects in the food industry, antibacterial preservation, food additives, food packaging, and other fields. This paper introduces nano-carrier materials and preparation techniques for loading and encapsulating active antibacterial substances in detail by constructing a nano-release system for active antibacterial substances. The antibacterial effect can be achieved by protecting them from adverse external conditions and destroying the membrane of pathogenic microorganisms. The mechanism of the slow release of the bacteriostatic active substance is also described. The mechanism of carrier loading and release is mainly through non-covalent forces between the bacteriostatic active substance and the carrier material, such as hydrogen bonding, π-π stacking, van der Waals forces, electrostatic interactions, etc., as well as the loading and adsorption of the bacteriostatic active substance by the chemical assembly. Finally, its wide application in food and medicine is introduced. It is hoped to provide a theoretical basis and technical support for the efficient utilization and product development of bacteriostatic active substances.

Research advances of nanomaterials for the acceleration of fracture healing

“…The surrounding immune cells secrete important pro-inflammatory factors due to bacteria proliferation, aggravating the inflammatory response and ROS accumulation. Moreover, the activated osteoclasts in bone tissue cause osteoclast differentiation and bone resorption [ 47 , 48 ], thereby causing bone repair failure. Accordingly, with their antibacterial properties, some nanomaterials can become drug carriers and assist antibiotics in strengthening the killing effect on drug-resistant bacteria, which has become the focus of researchers.…”