Embedded in the centuries-old assertion that the womb was a nomadic entity wandering about the body causing hysteria and distress, persistent menstrual misinformation and misconceptions remain prevalent wherein pain disorders like endometriosis are concerned. Affecting an estimated 176 million individuals worldwide, endometriosis is a major cause of non-menstrual pain, dyspareunia, painful menses and reduced quality of life among individuals of all races and socioeconomic backgrounds. Wide-ranging symptoms may be dismissed as routine by both patients and practitioners alike due to lack of disease literacy, and lengthy diagnostic delays can exacerbate the negative impact of endometriosis on the physical, psychological, emotional and social well-being of those affected. This chapter identifies some of these challenges and explores how obstacles to best practice can be reduced in part through adoption of early educational campaigns which incorporate endometriosis as a major component of menstrual health education.