Construction of one dimensional Co(II) and Zn(II) coordination polymers based on expanded N,N′-donor ligands

Zahedi, Mansoureh; Shaabani, Behrouz; Aygün, Muhıttın; Kazak, Canan

doi:10.1016/j.ica.2017.09.023

Cited by 8 publications

(3 citation statements)

References 54 publications

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“…Selected bond distances and bond angles data are presented in 1B and S5). 38 The lipophilicity of 1-3 was determined by measuring the extent to which it partitioned between octanol and water, P. The experimentally determined LogP values varied from 0.94 ± 0.33 to 1.91 ± 0.12 (Table S4). The lipophilic nature of the complexes suggests that 1-3 will readily cross the phospholipid bilayer and accumulate in cells.…”

Section: Synthesis Characterisation and Lipophilicitymentioning

confidence: 99%

Synthesis, characterization, and cytotoxic properties of mono- and di-nuclear cobalt(ii)-polypyridyl complexes

et al. 2018

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We report the synthesis and characterisation of mono- and di-nuclear cobalt(ii) complexes (1-3) containing L1, a polypyridyl ligand with pyrazole moieties. DNA binding studies suggest that the mono-nuclear complex, 1, binds to DNA via the grooves prior to inducing oxidative DNA cleavage whereas the larger di-nuclear complexes, 2 and 3, bind to DNA via the grooves and through intercalation prior to inducing oxidative DNA cleavage. The cobalt(ii) complexes display micromolar potency towards U2OS (bone osteosarcoma), HepG2 (liver hepatocellular carcinoma), and GM05757 (normal human fibroblast) cells, comparable to clinically used platinum agents, cisplatin and carboplatin. The cellular mechanism of action studies show that the most effective cobalt(ii) complex, 2, enters U2OS cells, penetrates the nucleus, induces genomic DNA damage, and triggers caspase-dependent apoptosis in a p53-independent manner. This study highlights the potential of di-nuclear cobalt(ii) complexes as artificial oxidative metallonucleases and tangible cancer cell-potent agents.

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Section: Synthesis Characterisation and Lipophilicitymentioning

confidence: 99%

Synthesis, characterization, and cytotoxic properties of mono- and di-nuclear cobalt(ii)-polypyridyl complexes

et al. 2018

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“…In addition, several authors have reported the synthesis of extended metal-containing crystal networks through metal–organic frameworks − and coordination polymers − and, in a smaller proportion, through the use of intermolecular interactions.…”

Section: Introductionmentioning

confidence: 99%

Controlling π–π Interactions through Coordination Bond Formation: Assembly of 1-D Chains of acac-Based Coordination Compounds

León-Zárate

Valdés-Martı́nez

2021

Crystal Growth & Design

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We present a new approach for the construction of 1-D chains of acac-based copper coordination compounds assembled through π−π aromatic interactions. We use 3-(phenylethynyl)pyridine derivatives as ligands that can establish aromatic interactions to intermolecularly bind the coordination compounds. The crystal networks of the free pyridines show that there is no control over aromatic interactions, since different interactions are present. On the other hand, the supramolecular behavior of the coordination compounds is very homogeneous since, in all of the crystal networks, the intended 1-D chains are present. Given the polarization of the aromatic rings due to coordination, reflected in the calculated molecular electrostatic potential maps, we gain control over the π−π interaction geometry, promoting a head to tail interaction between the coordinated 3-(phenylethynyl)pyridines. This strategy to constructing 1-D chains is reliable and reproducible; thus, these types of π−π aromatic interactions are a useful supramolecular tool to control the molecular assembly in the solid state.

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“…Li et al introduced 1-D and 2-D structures in which L is coordinated to Fe(II) cations [14]. Previous systematic work from our group on the synthesis of coordination polymers containing this dipyridyl ligand is documented [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

A series of 1-D zinc(II) coordination polymers with 3-D supramolecular networks: synthesis, structural investigation, and NBO analysis

Zahedi

Shaabani

Rad-Yousefnia

et al. 2018

Journal of Coordination Chemistry

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Construction of one dimensional Co(II) and Zn(II) coordination polymers based on expanded N,N′-donor ligands

Cited by 8 publications

References 54 publications

Synthesis, characterization, and cytotoxic properties of mono- and di-nuclear cobalt(ii)-polypyridyl complexes

Synthesis, characterization, and cytotoxic properties of mono- and di-nuclear cobalt(ii)-polypyridyl complexes

Controlling π–π Interactions through Coordination Bond Formation: Assembly of 1-D Chains of acac-Based Coordination Compounds

A series of 1-D zinc(II) coordination polymers with 3-D supramolecular networks: synthesis, structural investigation, and NBO analysis

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