Construction of pH responsive periodic mesoporous organosilica with histidine framework (His-PMO) for drug delivery

Mesoporous organosilica nanoparticles: Degradation strategies and application in tumor therapy

“…Similar with the pH-sensitive cleavage mechanism of organic bonds, Zhang et al prepared a histidine-bridged alkoxysilane and mixed with TEOS as a silica source, which was applied to synthesize a pH-sensitive biodegradable MONs by using P123 as a structure directing agent. 47 The results showed that the histidine-hybridized MONs possessed pHtriggered degradation behavior due to the cleavage of histidine moieties in acidic environment, which contributed to the relatively rapid drug release from MONs.…”

“…For example, Zhang et al reported a biodegradable MONs with histidine moieties for tumor chemotherapy. 47 Here, pH-sensitive histidine was hybridized in MONs to achieve pH-triggered degradation. The hybridization of histidine in the silica framework enhanced the loading capacity of hydrophobic antitumor drug paclitaxel (PTX) to 28 mg/g, owing to the imidazole groups of histidine as binding sites for hydrophobic PTX.…”

“…More importantly, the PTX release rate at low pH value (pH 5.2) was much faster than that at neutral pH value (pH 7.4), suggesting that more hydrophobic PTX drugs could be released in acidic tumor sites for enhancing the chemotherapeutic efficacy. 47 Yue et al designed HepG2 cell membrane (CM) coated disulfide-bridged MONs (ss-MONs) for hydrophobic Berberine (Ber) delivery. After loading Ber in carboxylated ss-MONs (ss-MONs-Ber), HepG2 cell membrane was coated on ss-MONs-Ber to obtain MONs-based Ber delivery system (CM-ss-MONs-Ber), which increased the homologous targeting property and immune escape capacity (Figure 5A).…”

Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

“…12). 91 Capitalizing on the abundant functional groups of histidine and the distinctive mesoporous channels of PMO, His-PMO exhibited robust electrostatic interactions with drugs and displayed a notable drug loading capacity of up to 28 mg g À1 . In vitro drug release investigations were conducted using various pH culture media.…”

Recent Development to Explore the Use of Biodegradable Periodic Mesoporous Organosilica (BPMO) Nanomaterials for Cancer Therapy

“…The high electrostatic interaction with the anti-cancer drug results in the high loading amount (28 mg/g). Finally, the results show that the release percentage and speed of paclitaxel (PTX) are completely dependent on pH values [44].…”