Construction of photoresponsive azobenzene-decorated cationic surfactant-based self-assembled vesicles and controlled drug release

Li, Nini; Yun, Le; Ji, Xiaohong; Mukherjee, Somnath; Wang, Changhao

doi:10.1016/j.colsurfa.2021.127711

Cited by 8 publications

(1 citation statement)

References 37 publications

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“…In the case of β–γ-CD/PEG-C 60 /IR780 = 4/3/4 (NPs 3; [β–γ-CD] = 0.5 mM), clear and well-defined hollow vesicles with an average diameter of ∼235 nm in water were observed and detected by TEM and DLS, respectively. As for the appearance of black points in the TEM image, the reason might be due to the small aggregates of inclusion complexes or self-aggregation of partial drug molecules during the period of π–π interactions, which were captured inside the vesicles during the assembly process. − The SEM image showed an obvious craterlike nanoparticle morphology, verifying the collapse in the middle of the hollow structure. The AFM image also exhibited a “concave–convex” structure with a dark center and light periphery, which was consistent with the “M” configuration reflected by the height diagram.…”

Section: Resultsmentioning

confidence: 99%

Asymmetric Cyclodextrin-Dimer-Involved Nanoassemblies by Selective Host–Guest Interactions: Concentration-Dependent Morphology Evolution and Light-Regulated Biomedical Applications

Li,

Yan,

Jiang

et al. 2024

Biomacromolecules

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Supramolecular assembly has attracted significant attention and has been applied to various applications. Herein, a β−γ-CD dimer was synthesized to complex different guest molecules, including single-strand polyethylene glycol (PEG)modified C 60 (PEG-C 60 ), photothermal conversion reagent (IR780), and dexamethasone (Dexa), according to the complexation constant-dependent specific selectivity. Spherical or cylindrical nanoparticles, monolayer or bilayer vesicles, and bilayer fusion vesicles were discovered in succession if the concentration of PEG-C 60 was varied. Moreover, if near-infrared light was employed to irradiate these nanoassemblies, the thermo-induced morphological evolution, subsequent cargo release, photothermal effect, and singlet oxygen ( 1 O 2 ) generation were successfully achieved. The in vitro cell experiments confirmed that these nanoparticles possessed excellent biocompatibility in a normal environment and achieved superior cytotoxicity by light regulation. Such proposed strategies for the construction of multilevel structures with different morphologies can open a new window to obtain various host−guest functional materials and achieve further use for disease treatment.

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Section: Resultsmentioning

confidence: 99%