Construction of polysaccharide based physically crosslinked double-network antibacterial hydrogel

Shi, Chao; Yang, Faming; Hu, Le; Wang, Hongbo; Wang, Yuxin; Wang, Zhouchi; Pan, Selina; Chen, Jingdi

doi:10.1016/j.matlet.2022.132048

Cited by 23 publications

(6 citation statements)

References 6 publications

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“…[18] There are three main approaches that have been utilized to enhance the mechanical strength of injectable hydrogels: [19] i) Adjusting the concentration or modifying the gel; ii) Creating a dual interconnection network structure; iii) Incorporating nanoparticles or nanofibers into the hydrogel. [20][21][22] Nanohydroxyapatite (nHA), with the chemical formula Ca 10 (PO 4 ) 6 (OH) 2 and a Ca/P ratio of 1.67, is a major component of the mineral phase of bone and an additional scaffolding component for bone regeneration. [23,24] nHA is frequently employed as a substitute for natural bone material owing to its similar chemical composition, structure, and density.…”

Section: Introductionmentioning

confidence: 99%

Study of Injectable Hydrogel Based on ALN/nHA Promoting Osteogenesis and Inhibiting Osteoclasts in Osteoporotic Bone Defects Repair

Yang,

Chen,

Chen

et al. 2024

Macromolecular Bioscience

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Osteoporotic bone defects cannot withstand surgery with more significant trauma due to bone fragility, while systemic drug therapy has formidable adverse effects. Consequently, the present study introduces an innovatively devised injectable double‐crosslinked hydrogel, as a potential therapeutic avenue for addressing varied shapes of osteoporotic bone defects via a minimally invasive approach. The injectable hydrogel was formed by the formation of Schiff base bonds between oxidized sodium alginate (OSA) and carboxymethyl chitosan, and the polymerization of gelatin methacrylate by ultraviolet light crosslinking. Additionally, alendronate sodium (ALN) was loaded into the hydrogel through Schiff base formation with OSA, and nanohydroxyapatite (nHA) was incorporated into the hydrogel via blending. The hydrogel demonstrated excellent injectability, and the nHA improved the mechanical property of hydrogel and can promote bone formation. In addition, the hydrogle can sustain release of ALN, which has the effect of inhibiting osteoclast. Cell studies indicated that the hydrogel can promote the differentiation of osteoblasts and inhibit the activity osteoclast, so as to obtain better osteogenic effect. Therefore, the injectable hydrogel can be used to repair osteoporotic bone defects through a minimally invasive, simple treatment modality.This article is protected by copyright. All rights reserved

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Section: Introductionmentioning

confidence: 99%

Study of Injectable Hydrogel Based on ALN/nHA Promoting Osteogenesis and Inhibiting Osteoclasts in Osteoporotic Bone Defects Repair

Yang,

Chen,

Chen

et al. 2024

Macromolecular Bioscience

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“…Therefore, based on the above advantages, various physically cross-linked hydrogel systems have attracted the attention of researchers in recent years. However, due to the lack of covalently bonded cross-linked structures, the network structures of physically cross-linked hydrogels are often not stable enough, resulting in poor swelling stability, easy dissolution upon prolonged immersion in water, and low macroscopic strength, making it difficult to meet the practical requirement [ 33 , 34 ]. In order to improve the stability of both the chemically and physically cross-linked hydrogels and increase the mechanical strength, many researchers have described various strategies to synthesize high-strength gels, such as nanocomposite hydrogels [ 35 , 36 ], interpenetrating hydrogels [ 37 ] and dual-network hydrogels [ 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

“…Cross-linking with multivalent metal ions is also an effective way to improve the mechanical properties of hydrogels and impart self-healing properties [ 47 , 48 , 49 ]. The synthesis of dual or multiple physically cross-linked hydrogels was a feasible strategy to simultaneously improve the strength and self-healing properties of hydrogels, e.g., Jingdi Chen et al used sodium alginate, chitosan, and zinc ions to prepare high-strength and non-biotoxic double physically cross-linked hydrogels for wound dressings [ 34 ], and Jieshan Qiu et al used PVA, carboxymethyl cellulose, and zinc ions to prepare high-strength physically cross-linked hydrogels for the preparation of supercapacitors [ 47 ]. There have been many reports on the synthesis of hydrogels with dual or multiple physical cross-linking structures, and very good results were achieved in the synthesis of high-strength hydrogels, but these articles mainly focused on multiple hydrogen-bonded cross-linking structures or the combination of hydrogen-bonded cross-linking structures and ionic interactions, which may lack cross-linking interactions and material selectivity.…”

Section: Introductionmentioning

confidence: 99%

Multi-Physically Cross-Linked Hydrogels for Flexible Sensors with High Strength and Self-Healing Properties

Zhang,

Wang,

Tian

et al. 2023

Polymers

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Excellent mechanical properties and self-healing properties are very important for the practical application of hydrogel flexible sensors. In this study, acrylic acid and stearyl methyl acrylate were selected as monomers to synthesize hydrophobic association hydrogels, and multi-physically cross-linked hydrogels were synthesized by adding ferric chloride and polyvinyl alcohol to introduce ion interaction and a hydrogen bond cross-linking network. The hydrogels were characterized by FTIR, XRD and SEM, and the mechanical properties and self-healing properties were tested using a universal testing machine. It was confirmed that the strength of the hydrogel was significantly improved with the addition of ferric chloride and polyvinyl alcohol, and the hydrogel still showed good self-healing properties. Further testing of its application as a conductive sensor has demonstrated sensitive and stable motion sensing capabilities. This provides an important reference for high-performance hydrogel sensors with both high strength and self-healing properties.

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“…The final structure of gel network is thus stabilized by noncovalent interactions. [27][28][29] This review mainly aims to offer more insights into the recent development of polysaccharide-based physical hydrogels for biomedical and environmental applications. In the first place, different strategies employed for the preparation of these hydrogels and formation mechanism are discussed in detail.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Polysaccharide‐Based Physical Hydrogels and Their Potential Applications for Biomedical and Wastewater Treatment

Zhang

Yan

Tang

2022

Macromolecular Bioscience

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Polysaccharides are widely employed to fabricate hydrogels owing to their intrinsic properties including biocompatibility, biodegradability, sustainability, and easy modification. However, a considerable amount of polysaccharide‐based hydrogels are prepared by chemical crosslinking method using organic solvents or toxic crosslinkers. The presence of reaction by‐products and residual toxic substances in the obtained materials causes a potential secondary pollution risk and thus severely limits their practical applications. In contrast, polysaccharide‐based physical hydrogels are preferred over chemically derived hydrogels and can be used to address existing drawbacks of chemical hydrogels. The polysaccharide chains of such hydrogel are typically crosslinked by dynamic noncovalent bonds, and the co‐existence of multiple physical interactions stabilizes the hydrogel network. This review focuses on providing a detailed outlook for the design strategies and formation mechanisms of polysaccharide‐based physical hydrogels as well as their specific applications in tissue engineering, drug delivery, wound healing, and wastewater treatment. The main preparation principles, future challenges, and potential improvements are also outlined. It is hoped that this review can provide valuable information for the rational fabrication of polysaccharide‐based physical hydrogel. The specific research works listed in the review can provide a systematic and solid research basis for the reliable development of polysaccharide‐based physical hydrogel.

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Construction of polysaccharide based physically crosslinked double-network antibacterial hydrogel

Cited by 23 publications

References 6 publications

Study of Injectable Hydrogel Based on ALN/nHA Promoting Osteogenesis and Inhibiting Osteoclasts in Osteoporotic Bone Defects Repair

Study of Injectable Hydrogel Based on ALN/nHA Promoting Osteogenesis and Inhibiting Osteoclasts in Osteoporotic Bone Defects Repair

Multi-Physically Cross-Linked Hydrogels for Flexible Sensors with High Strength and Self-Healing Properties

Recent Advances in Polysaccharide‐Based Physical Hydrogels and Their Potential Applications for Biomedical and Wastewater Treatment

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