Construction of quaternary ammonium chitosan-coated protein nanoparticles as novel delivery system for curcumin: Characterization, stability, antioxidant activity and bio-accessibility

Liu, Qianyuan; Zhang, Qian; Jia, Feihong; Jiang, Ning; Wang, Cheng; Sun, Rongxue; Ma, Yanhong

doi:10.1016/j.foodchem.2024.139923

Food Chemistry

2024

DOI: 10.1016/j.foodchem.2024.139923

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Construction of quaternary ammonium chitosan-coated protein nanoparticles as novel delivery system for curcumin: Characterization, stability, antioxidant activity and bio-accessibility

Qianyuan Liu,

Qian Zhang,

Feihong Jia

et al.

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Cited by 3 publications

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Enhanced pH-sensitive anthocyanin film based on chitosan quaternary ammonium salt: A promising colorimetric indicator for visual pork freshness monitoring

Ma,

Wen,

Liu

et al. 2024

International Journal of Biological Macromolecules

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Enhanced pH-sensitive anthocyanin film based on chitosan quaternary ammonium salt: A promising colorimetric indicator for visual pork freshness monitoring

Ma,

Wen,

Liu

et al. 2024

International Journal of Biological Macromolecules

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Modification of Inca peanut albumin–polyphenol conjugates by chitosan through laccase catalysis: Structural, interfacial, and functional properties

Yang,

Deng,

Chen

et al. 2025

International Journal of Biological Macromolecules

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Preparation and Characterization of Small-Size and Strong Antioxidant Nanocarriers to Enhance the Stability and Bioactivity of Curcumin

Tie,

Yang,

Ding

et al. 2024

Foods

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The purpose of this study was to design nanocarriers with small-size and antioxidant properties for the effective encapsulation of curcumin. Here, procyanidins, vanillin, and amino acids were used to successfully prepare nanocarriers of a controllable size in the range of 328~953 nm and to endow antioxidant ability based on a one-step self-assembly method. The reaction involved a Mannich reaction on the phenolic hydroxyl groups of procyanidins, aldehyde groups of vanillin, and amino groups of amino acids. Subsequently, curcumin nanoparticles were prepared by loading curcumin with this nanocarrier, and the encapsulation efficiency of curcumin was 85.97%. Compared with free curcumin, the antioxidant capacity and photothermal stability of the embedded curcumin were significantly improved, and it could be slowly released into simulated digestive fluid. Moreover, using the corticosterone-induced PC12 cell injury model, the cell viability increased by 23.77% after the intervention of curcumin nanoparticles, and the cellular antioxidant capacity was also significantly improved. The nanoparticles prepared in this work can effectively improve the solubility, stability, and bioactivity of curcumin, which provides a reference for the embedding and delivery of other hydrophobic bioactive compounds.

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Construction of quaternary ammonium chitosan-coated protein nanoparticles as novel delivery system for curcumin: Characterization, stability, antioxidant activity and bio-accessibility

Cited by 3 publications

References 52 publications

Enhanced pH-sensitive anthocyanin film based on chitosan quaternary ammonium salt: A promising colorimetric indicator for visual pork freshness monitoring

Enhanced pH-sensitive anthocyanin film based on chitosan quaternary ammonium salt: A promising colorimetric indicator for visual pork freshness monitoring

Modification of Inca peanut albumin–polyphenol conjugates by chitosan through laccase catalysis: Structural, interfacial, and functional properties

Preparation and Characterization of Small-Size and Strong Antioxidant Nanocarriers to Enhance the Stability and Bioactivity of Curcumin

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