Construction of selenium nanoparticles/β-glucan composites for enhancement of the antitumor activity

Jia, Xuewei; Liu, Qingye; Zou, Siwei; Xu, Xiaojuan; Zhang, Lina

doi:10.1016/j.carbpol.2014.09.088

Cited by 144 publications

(68 citation statements)

References 38 publications

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“…The toxicity assay result of this study revealed that the highest viability level at the same concentration (1024 μg/ml) is related to M (85%); in comparison with SeNPs (71.6%) and CCH (61.8%). According to the previous studies, toxicity of SeNPs is less than that of Se 15,20 . In this research, reduction in the viability percentage of CCH (71.6%) compared to chitosan can be due to the presence of CTAB.…”

Section: Discussionmentioning

confidence: 93%

Synergistic Antibacterial Activity and Wound Healing Properties of Selenium-Chitosan-Mupirocin Nanohybrid System: An in Vivo Study on Rat Diabetic Staphylococcus aureus Wound Infection Model

Golmohammadi

Peerayeh

Moghadam

et al. 2020

Sci Rep

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the current study aimed to formulate Selenium-chitosan-Mupirocin (M-Senps-ccH) complex. the nanohybrid system was prepared using chitosan-cetyltrimethylammonium bromide (ctAB)based hydrogel (ccH) that entrapped mupirocin (M) and selenium nanoparticles (Senps). the in vitro studies were performed by evaluation of the antibacterial activity and toxicity on L929 mouse fibroblast cell line. The in vivo study was conducted on rat diabetic wound infection model that was infected by mupirocin-methicillin-resistant Staphylococcus aureus (MMRSA). the wounds were treated by M-SeNPs-CCH nanohybrid system with concentrations of M; 20 mg/ml, CCH; 2 mg/ml and SeNPs; 512 μg/ml in two times/day for 21 days. The therapeutic effect of this nanohybrid system was evaluated by monitoring wound contraction and histopathological changes. evaluation of the average wound healing time showed a significant difference between the treatment and control groups (P≤0.05). The histopathological study indicated that the amount of wound healing was considerable in M-Senps-ccH nanohybrid system groups compared to the control and M groups. the M-Senps-CCH nanohybrid system formulated in this study was able to reduce 3-fold MIC of mupirocin with synergistic antibacterial activity as well as to play a significant role in wound contraction, angiogenesis, fibroblastosis, collagenesis, proliferation of hair follicle, and epidermis growth compared to the control group (P ≤ 0.05). This research suggests that this nanohybrid system might be a development for the treatment of diabetic wound infection at mild stage. Management of the infectious diabetic foot ulcer remains a global health issue 1,2. According to the World Health Organization (WHO), about 422 million people worldwide suffer from diabetes 2. About 25% of diabetic patients experience diabetic foot wounds in their lifetime 3,4 , half of them suffer infection 3. Diabetic wounds are classified into three groups, i.e. mild, moderate and severe 3. To avoid amputation and reduce health care costs, it is essential to control the infection 5. Gram-positive bacteria such as Staphylococcus aureus and beta-hemolytic streptococci are common infectious agents in the mild stage of diabetic foot wounds 3,5. Regarding the increasing incidence of antibiotic-resistant strains such as methicillin-resistant S. aureus (MRSA) 6,7 , the treatment of infection caused by this organism has

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Section: Discussionmentioning

confidence: 93%

Synergistic Antibacterial Activity and Wound Healing Properties of Selenium-Chitosan-Mupirocin Nanohybrid System: An in Vivo Study on Rat Diabetic Staphylococcus aureus Wound Infection Model

Golmohammadi

Peerayeh

Moghadam

et al. 2020

Sci Rep

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“…A wide variety of properties shown by selenium nanoparticles are free radical scavenging (Huang et al 2003), antioxidant (Forootanfar et al 2014;Kong et al 2014;Mittal et al 2014;Ramya et al 2015;Rezvanfar et al 2013;Torres et al 2012;, chemoprotection against chemotherapy-induced reproductive toxicity (Rezvanfar et al 2013) and UV-induced DNA damage (Prasad et al 2013), immunomodulatory, anti-inflammatory (Wang et al 2014), nanomedicinal , chemotherapeutic and chemoprevention against human melanoma and hepatoma cancers Estevez et al 2014;Peng et al 2007), biofortification (Durán et al 2015), and antitumor and anticancer (Jia et al 2015;Kumar et al 2015;Mittal et al 2014;Ren et al 2013) activities. Other applications include antibacterial, antibiofilm (Bartůněk et al 2015;Hariharan et al 2012;Huang et al 2016;Mittal et al 2014;Ramya et al 2015;Shakibaie et al 2015;Tran and Webster 2011;Wang and Webster 2013), antifungal, antiprotozoan, antitapeworm (Bartůněk et al 2015), antiviral, wound healing (Ramya et al 2015), and cytotoxic (Forootanfar et al 2014;Ramya et al 2015) activities.…”

Section: Introductionmentioning

confidence: 99%

Bacillus cereus, selenite-reducing bacterium from contaminated lake of an industrial area: a renewable nanofactory for the synthesis of selenium nanoparticles

Kora

2018

Bioresour. Bioprocess.

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Background: An attempt was made to isolate selenite-reducing bacteria from a contaminated lake that receives industrial effluents and domestic sewage. The isolated dominant bacterial strain AJK3 was identified as Bacillus cereus, based on biochemical characterization and 16S rDNA sequencing. The time dependent selenium removal at different selenite concentrations monitored with ICP-AES indicates the substantial selenite reduction capability of the isolated strain. The selenium nanoparticles produced during the bacterial reduction of selenite were analyzed with UV-visible spectroscopy, X-ray diffraction, transmission electron microscopy, zeta potential measurement, Fourier transform infrared spectroscopy and Raman spectroscopy. Results:The nanoparticle synthesis was confirmed from the red colour emergence in culture broth and wide UV-vis peaks. The produced nanoparticles were polydisperse, spherical, size varied from 50 to 150 nm and the mean particle size was about 93 nm. The amorphous nature of the generated nanoparticles was confirmed from the Raman spectroscopy, XRD and SAED patterns. The IR data and zeta potential values substantiated the protein capping of the produced nanoparticles. Conclusions:Thus, the present study suggests that the isolated bacterial strain can be exploited as a prospective, renewable, natural, nanofactory for the bacteriogenic synthesis of nanoparticles. Also, the study has application in bioremediation of selenite from the contaminated environment.

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“…Its interaction with GPx is particularly important and well-understood, since GPx is known to play a significant role in scavenging various peroxides and protecting membrane lipids and macromolecules from oxidative damage. 8,9 In the human diet, Se is particularly associated with the immune system, helping to enhance the immune response in both the innate and acquired immune systems. 10 It also stimulates cell cycle progression and prevents cell death.…”

Section: Introductionmentioning

confidence: 99%

Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats

Al‐Quraishy

Dkhil

Moneim

2015

IJN

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The study was designed to investigate the anti-hyperglycemic activity of selenium nanoparticles (SeNPs) in streptozotocin-induced diabetic rats. Fifty-five mg/kg of streptozotocin was injected in rats to induce diabetes. Animals either treated with SeNPs alone or with insulin (6 U/kg) showed significantly decreased fasting blood glucose levels after 28 days of treatment. The serum insulin concentration in untreated diabetic animals was also enhanced by SeNPs. The results demonstrated that SeNPs could significantly decrease hepatic and renal function markers, total lipid, total cholesterol, triglyceride and low-density lipoprotein cholesterol levels, and glucose-6-phosphatase activity. At the same time, SeNPs increased malic enzyme, hexokinase and glucose-6-phosphate dehydrogenase activity, liver and kidney glycogen contents, and high-density lipoprotein cholesterol levels. In addition, SeNPs were able to prevent the histological injury in the hepatic and renal tissues of rats. However, insulin injection also exhibited a significant improvement in diabetic animals after 28 days of treatment. This study suggests that SeNPs can alleviate hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats, possibly by eliciting insulin-mimetic activity.

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Construction of selenium nanoparticles/β-glucan composites for enhancement of the antitumor activity

Cited by 144 publications

References 38 publications

Synergistic Antibacterial Activity and Wound Healing Properties of Selenium-Chitosan-Mupirocin Nanohybrid System: An in Vivo Study on Rat Diabetic Staphylococcus aureus Wound Infection Model

Synergistic Antibacterial Activity and Wound Healing Properties of Selenium-Chitosan-Mupirocin Nanohybrid System: An in Vivo Study on Rat Diabetic Staphylococcus aureus Wound Infection Model

Bacillus cereus, selenite-reducing bacterium from contaminated lake of an industrial area: a renewable nanofactory for the synthesis of selenium nanoparticles

Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats

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