Construction of size-transformable supramolecular nano-platform against drug-resistant colorectal cancer caused by Fusobacterium nucleatum

Yan, Xiangjie; Ma, Feihe; Chen, Qixian; Gou, Xin; Li, Xiaohui; Zhang, Liuwei; Gao, Hui

doi:10.1016/j.cej.2022.137605

Cited by 21 publications

(28 citation statements)

References 47 publications

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“…coli, while it showed great antibacterial activity against Fn . This result was consistent with the bactericidal property of LA derivatives in the previous report. , …”

Section: Resultssupporting

confidence: 93%

“…However, OXA led to sharply increased cytotoxicity. This could be attributed to the polyhydroxy structure of PG, which could improve the biocompatibility of nanoassembly . Then, HT29 tumor cells were treated with OXA and OLP/PP nanoassemblies for 24 h to test the in vitro anticancer efficacy.…”

Section: Resultsmentioning

confidence: 99%

“…This could be attributed to the polyhydroxy structure of PG, which could improve the biocompatibility of nanoassembly. 27 Then, HT29 tumor cells were treated with OXA and OLP/PP nanoassemblies for 24 h to test the in vitro anticancer efficacy. As shown in Figure 4B, the cytotoxicity of OXA and OLP/PP to HT29 cells gradually increased with the increase of OXA concentration.…”

Section: In Vitro Antibacterial Activity Evaluationmentioning

confidence: 99%

“…25,26 Our previous work prepared supramolecular nanomedicine containing LA to eliminate Fn. 27 The nanomedicine could promote the chemotherapeutic efficacy by eliminating Fn and inhibiting autophagy. To enhance the targeting effect of the nanomedicine and effectively eliminate tumor-resident extracellular and intracellular Fn, here, an active tumor-targeting strategy was designed.…”

Section: Introductionmentioning

confidence: 99%

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Tumor-Targeting Nanoassembly for Enhanced Colorectal Cancer Therapy by Eliminating Intratumoral Fusobacterium nucleatum

Xin

et al. 2023

ACS Appl. Mater. Interfaces

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Fusobacterium nucleatum (Fn) has long been found to be related to colorectal cancer (CRC), which could promote colorectal tumor progression and cause cancer resistance to chemotherapy. Great efforts have been made to understand the relationship between Fn and CRC, but how to efficiently eliminate intratumoral Fn and overcome chemoresistance remains a critical challenge. Here, an active tumortargeting acidity-responsive nanomaterial toward eliminating intratumoral Fn is developed for enhancing the treatment of cancer. Lauric acid and phenylboric acid are conjugated to oligomethyleneimine to form OLP followed by interacting with oxaliplatin prodrug-modified polyglycidyl ether (PP) to obtain the OLP/PP nanoassembly. The nanoassembly shows good structural stability under the simulated physiological conditions and has a pH-responsive drug release in an acidic tumor microenvironment. More attractively, the nanoassembly can specifically target the tumor cell, guide cellular uptake, and efficiently eliminate tumor-resident extracellular and intracellular Fn. Through the on-site drug delivery, the nanoassembly can overcome chemoresistance and significantly inhibit tumor growth. Both in vitro and vivo studies show that the prepared nanoassembly presents good biocompatibility. Therefore, this biocompatible nanoassembly possessing efficient antibacterial and antitumor activities provides new promise for the therapy of bacterial infected tumors.

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“…coli, while it showed great antibacterial activity against Fn . This result was consistent with the bactericidal property of LA derivatives in the previous report. , …”

Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: In Vitro Antibacterial Activity Evaluationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Tumor-Targeting Nanoassembly for Enhanced Colorectal Cancer Therapy by Eliminating Intratumoral Fusobacterium nucleatum

Xin

et al. 2023

ACS Appl. Mater. Interfaces

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“…However, small-sized nanoparticles may undergo rapid clearance by the reticuloendothelial system (RES) during blood circulation [ 92 ]. Recently, several size-adjustable supramolecular-macrocycle-based drug delivery systems have been developed to solve this dilemma [ 93 , 94 , 95 ]. These nanoparticles usually have a relatively large size during blood circulation to ensure efficient tumor accumulation.…”

Section: Supramolecular-macrocycle-based Nanomaterials For Enhanced C...mentioning

confidence: 99%

Recent Advances in Supramolecular-Macrocycle-Based Nanomaterials in Cancer Treatment

Zheng

Zhao

et al. 2023

Molecules

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Cancer is a severe threat to human life. Recently, various therapeutic strategies, such as chemotherapy, photodynamic therapy, and combination therapy have been extensively applied in cancer treatment. However, the clinical benefits of these therapeutics still need improvement. In recent years, supramolecular chemistry based on host–guest interactions has attracted increasing attention in biomedical applications to address these issues. In this review, we present the properties of the major macrocyclic molecules and the stimulus–response strategies used for the controlled release of therapeutic agents. Finally, the applications of supramolecular-macrocycle-based nanomaterials in cancer therapy are reviewed, and the existing challenges and prospects are discussed.

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Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions

et al. 2024

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Chemotherapy is widely recognized as an effective approach for treating cancer due to its ability to eliminate cancer cells using chemotherapeutic drugs. However, traditional chemotherapy suffers from various drawbacks, including limited solubility and stability of drugs, severe side effects, low bioavailability, drug resistance, and challenges in tracking treatment efficacy. These limitations greatly hinder its widespread clinical application. In contrast, supramolecular chemotherapy, which relies host–guest interactions, presents a promising alternative by offering highly efficient and minimally toxic anticancer drug delivery. In this review, we provide an overview of recent advancements in supramolecular chemotherapy based on host–guest interactions. We emphasize the significant role it plays in guiding cancer therapy. Drawing on a wealth of cutting‐edge research, we aim to present a timely and valuable resource for individuals interested in the field of supramolecular chemotherapy or cancer therapy. Furthermore, we aspire to contribute to progression of the field of supramolecular chemotherapy toward clinical application.This article is protected by copyright. All rights reserved

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Construction of size-transformable supramolecular nano-platform against drug-resistant colorectal cancer caused by Fusobacterium nucleatum

Cited by 21 publications

References 47 publications

Tumor-Targeting Nanoassembly for Enhanced Colorectal Cancer Therapy by Eliminating Intratumoral Fusobacterium nucleatum

Tumor-Targeting Nanoassembly for Enhanced Colorectal Cancer Therapy by Eliminating Intratumoral Fusobacterium nucleatum

Recent Advances in Supramolecular-Macrocycle-Based Nanomaterials in Cancer Treatment

Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions

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