Construction of turmerone motif-fused spiropyrrolidine oxindoles and their biological evaluation for anticancer activities

Non-Curcuminoids from Turmeric and Their Potential in Cancer Therapy and Anticancer Drug Delivery Formulations

“…Researchers have accumulated data on the biological activities of non-curcuminoids and revealed that these components of turmeric have similar dynamic potential as curcuminoids and exhibits non-hepatotoxic, non-mutagenic, non-carcinogenic efficiency with the fewest side effects [16]. This review pioneers to collaborate all the foregoing extensive anticancer studies on some major non-curcuminoids (Figure 2) such as ar–turmerone, β–elemene, δ-elemene, furanodiene, furanodienone, curcumol, cyclocurcumin, calebin A, germacrone, bisacurone and curdione [33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,…”

“…Turmerones also showed promising results when motif–fused by spiropyrrolidine oxindoles through 1, 3 dipolar cyclo–addition events of dienones 2 with azomethine ylides, which were attached to it. These turmerones motif–fused spiropyrrolidine oxindoles showed more potency than cisplatin kept as control over human leukemia cells (K562) and human lung cancer cells (A549) [41].…”

Recent applications of isatin in the synthesis of organic compounds

“…88 The biological activity test results demonstrated that most of the compounds showed considerable cytotoxicities to cell lines of K562 and A549, showed comparably potent or even more potent than the positive control of cisplatin (up to 5.1 times).…”

The application of isatin-based multicomponent-reactions in the quest for new bioactive and druglike molecules

“…The group of Zhou and Lin used dienones as dipolarophiles to access a family of novel turmerone motif-fused spiropyrrolidine-oxindole derivatives in good yields (Scheme 7B) (25 examples e 70e93% yield). The desired products bearing adjacent chiral carbon centers were smoothly obtained also with good diastereoselectivity (>20:1) [67]. Barakat and co-workers reported the synthesis of one spirooxindole analogue based on the same 1,3-dipolar cycloaddition reaction of isatin, sarcosine and the olefin (…”