So far, we have developed Full-scale 3D Vibration Simulator for an Entire Nuclear Power Plant which is simulation platform to analyze seismic response of a whole digitalized nuclear power plant. In this work, we introduced pipelined data-transfer scenario in which boundary condition data between plant's components are transferred each time step from large components to small components while all components simulations are run in parallel. We developed grid-enabled application to perform this simulation more efficiently using various computing resources. In the development, we confronted two problems; first, pre-existing grid technology still does not sufficiently support to realize pipelined data-transfer and second, to realize long time simulation by the scenario, functionality enabling simulation restarting to be automated is necessary. As solution of these problems, we used Simple Orchestration Application Framework (SOAF) which enabled pipelined data-transfer to be realized in easy and simple way and simulation restarting to be automated. Using the SOAF, we developed grid-enabled application and succeeded seismic analysis simulation of a test reactor in pipelined data-transfer scenario for about a week. In this paper, the details of all of this work will be presented.