Ultra wide band (UWB)-based real-time location systems (RTLSs) have been widely adopted in the manufacturing industry for tracking tools, materials, and ensuring safety. Researchers in the construction domain have investigated similar uses for UWB-based RTLSs on construction jobsites. However, most of these investigations comprised small-scale experiments using average accuracy only to demonstrate use cases for the technology. Furthermore, they did not consider alternative deployment scenarios for practically feasible deployment of the technology. To overcome these limitations, a series of experiments were performed to study the feasibility of a commercially available RTLS on the construction jobsites. The focus of the work was on feasibility in terms of accuracy analysis of the system for a large experimental site, the level of effort requirements for deployment, and the impact of deployment alternatives on the accuracy of the system. The results found that average accuracy was found to be a misleading indicator of the perceived system performance (i.e., 95th percentile values were considerably higher than average values). Moreover, accuracy is significantly affected by the deployment alternatives. Collectively, the results arising from the study could help construction/safety managers in decision making related to the deployment of UWB-based RTLSs for their construction sites.