Constructive use of filamentous fungi to remove pharmaceutical substances from wastewater

Daļecka, Brigita; Juhna, Tālis; Rajarao, Gunaratna Kuttuva

doi:10.1016/j.jwpe.2019.100992

Cited by 39 publications

(15 citation statements)

References 35 publications

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“…Recent studies have shown prospects of biotechnology based on filamentous fungi for almost complete elimination of a wide range of pharmaceutical compounds that may have ecotoxic effects in the environment ( Table 2 ). Reports ( Dalecka et al, 2020a ; Dhiman et al, 2022 ) have shown that filamentous fungi can efficiently remove pharmaceutical compounds at level of 78%–100% from a synthetic wastewater media. Research of past years mostly have shown a slow rate of degradation of pharmaceutical compounds with a treatment duration of more than 26 days ( Li et al, 2015 ; Badia-Fabregat et al, 2016 ; Mir-Tutusaus et al, 2017 ).…”

Section: Recent Progress In Bioremediation By Filamentous Fungimentioning

confidence: 99%

Filamentous fungi for sustainable remediation of pharmaceutical compounds, heavy metal and oil hydrocarbons

Ghosh

Rusyn

Dmytruk

et al. 2023

Front. Bioeng. Biotechnol.

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This review presents a comprehensive summary of the latest research in the field of bioremediation with filamentous fungi. The main focus is on the issue of recent progress in remediation of pharmaceutical compounds, heavy metal treatment and oil hydrocarbons mycoremediation that are usually insufficiently represented in other reviews. It encompasses a variety of cellular mechanisms involved in bioremediation used by filamentous fungi, including bio-adsorption, bio-surfactant production, bio-mineralization, bio-precipitation, as well as extracellular and intracellular enzymatic processes. Processes for wastewater treatment accomplished through physical, biological, and chemical processes are briefly described. The species diversity of filamentous fungi used in pollutant removal, including widely studied species of Aspergillus, Penicillium, Fusarium, Verticillium, Phanerochaete and other species of Basidiomycota and Zygomycota are summarized. The removal efficiency of filamentous fungi and time of elimination of a wide variety of pollutant compounds and their easy handling make them excellent tools for the bioremediation of emerging contaminants. Various types of beneficial byproducts made by filamentous fungi, such as raw material for feed and food production, chitosan, ethanol, lignocellulolytic enzymes, organic acids, as well as nanoparticles, are discussed. Finally, challenges faced, future prospects, and how innovative technologies can be used to further exploit and enhance the abilities of fungi in wastewater remediation, are mentioned.

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Section: Recent Progress In Bioremediation By Filamentous Fungimentioning

confidence: 99%

Filamentous fungi for sustainable remediation of pharmaceutical compounds, heavy metal and oil hydrocarbons

Ghosh

Rusyn

Dmytruk

et al. 2023

Front. Bioeng. Biotechnol.

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“…When it comes to KTP, its complex composition and the presence of various functional groups (methyl, ketone, and carboxylic) contribute to its weak sorption and strong desorption capabilities ( Yu et al, 2011 ). The carboxylic functional group (-COOH), which acts as an electron acceptor, creates an electron deficit, making the compound less susceptible to oxidative catabolism ( Dalecka et al, 2020 ).…”

Section: Bioremoval Of Ketoprofenmentioning

confidence: 99%

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

Tyumina,

Subbotina,

Polygalov

et al. 2023

Front. Microbiol.

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Ketoprofen, a bicyclic non-steroidal anti-inflammatory drug commonly used in human and veterinary medicine, has recently been cited as an environmental contaminant that raises concerns for ecological well-being. It poses a growing threat due to its racemic mixture, enantiomers, and transformation products, which have ecotoxicological effects on various organisms, including invertebrates, vertebrates, plants, and microorganisms. Furthermore, ketoprofen is bioaccumulated and biomagnified throughout the food chain, threatening the ecosystem function. Surprisingly, despite these concerns, ketoprofen is not currently considered a priority substance. While targeted eco-pharmacovigilance for ketoprofen has been proposed, data on ketoprofen as a pharmaceutical contaminant are limited and incomplete. This review aims to provide a comprehensive summary of the most recent findings (from 2017 to March 2023) regarding the global distribution of ketoprofen in the environment, its ecotoxicity towards aquatic animals and plants, and available removal methods. Special emphasis is placed on understanding how ketoprofen affects microorganisms that play a pivotal role in Earth’s ecosystems. The review broadly covers various approaches to ketoprofen biodegradation, including whole-cell fungal and bacterial systems as well as enzyme biocatalysts. Additionally, it explores the potential of adsorption by algae and phytoremediation for removing ketoprofen. This review will be of interest to a wide range of readers, including ecologists, microbiologists, policymakers, and those concerned about pharmaceutical pollution.

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“…Lac enzyme was shown to preferentially remove diclofenac, naproxen, indomethacin, and this indicated that intracellular enzymes may be involved in the degradation of other compounds. T. versicolor removed >99.9% and ~40% of diclofenac and ketoprofen, respectively, within 14 days (Dalecka et al, 2019). The removal mechanism was found to be related to the production of laccase along with biosorption.…”

Section: Fungal Degradation Of Pharmaceuticals and Personal Care Prod...mentioning

confidence: 92%

“…Fungi have been shown to break down a range of pharmaceuticals ranging from antibiotics (Rodarte-Morales et al, 2011), antiinflammatory drugs (Dalecka et al, 2019), anticancer drugs (Jureczko et al, 2021), antidepressants (Rodarte-Morales et al, 2011), diuretics (Al-Aboudi et al, 2017), analgesics (Marco-Urrea et al, 2009b) and beta-blockers (Jaeń-Gil et al, 2019). The most studied fungal group able to degrade pharmaceuticals, are WRF.…”

Section: Fungal Degradation Of Pharmaceuticals and Personal Care Prod...mentioning

confidence: 99%

Role of fungi in bioremediation of emerging pollutants

et al. 2023

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Advancements in chemical, medical, cosmetic, and plastic producing industries have improved agricultural yields, health and human life in general. As a negative consequence, a plethora of chemicals are intentionally and unintentionally released to terrestrial and aquatic environments with sometimes devastating effects for entire ecosystems. One mitigation strategy to counteract this pollution is bioremediation. Bioremediation is an umbrella term for biologically mediated processes during which an undesired compound is transformed, degraded, sequestered and/or entirely removed from the ecosystem. Organisms across all domains of life may mediate bioremediation; yet, fungi are particularly promising candidates. They possess metabolic capabilities to break down complex molecules which make fungi the ultimate degraders of recalcitrant organic matter in nature. Bioremediation by fungi, also termed mycoremediation, has been more frequently investigated in terrestrial than aquatic ecosystems, although fungi also thrive in lacustrine and marine environments. Here, we focus on mycoremediation of emerging pollutants in aquatic environments. In this context, we draw parallels between terrestrial and aquatic fungal taxa, and their role in mycoremediation. We discuss the ability of fungi to break-down (i) pesticides, (ii) pharmaceuticals and personal care products, (iii) plastics, both conventional types and (iv) bioplastics, and fungal role, (v) mitigation of heavy metal pollution. Furthermore, we (vi) discuss possible mycoremediation strategies in applied settings and highlight novel enzyme based mycoremediation strategies.

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Constructive use of filamentous fungi to remove pharmaceutical substances from wastewater

Cited by 39 publications

References 35 publications

Filamentous fungi for sustainable remediation of pharmaceutical compounds, heavy metal and oil hydrocarbons

Filamentous fungi for sustainable remediation of pharmaceutical compounds, heavy metal and oil hydrocarbons

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

Role of fungi in bioremediation of emerging pollutants

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