Consultas por intoxicación etílica aguda en un servicio de urgencias pediátricas

Marcos, N. Sanz; Constantí, Vanessa Arias; Maza, Victoria Trenchs Sainz de la; Barcenilla, A.I. Curcoy; Costa, J.; Cubells, Carles Luaces

doi:10.1016/j.anpedi.2008.10.006

Cited by 8 publications

(10 citation statements)

References 10 publications

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“…The admission rate was higher than in other analyzed series, 1,15 and this difference may be attributed to the higher mean ethanolemia, data supported by the study of Boban et al 14 in which the blood ethanol levels of the hospitalized patients analyzed are closer to our data. In addition, about a quarter of the patients who required admission were admitted to the psychiatry department for assessment at this level, 16,22 and not for needing treatment from the organic point of view.…”

Section: Discussionsupporting

confidence: 91%

“…In this regard, the importance of restoring potassium levels and maintenance with moderate amounts in serum therapy should be emphasized 21 to completely correct metabolic alkalosis, given that preserved renal function tends to maintain electroneutrality at the expense of excreting hydrogenions. The admission rate was higher than in other analyzed series, 1,15 and this difference may be attributed to the higher mean ethanolemia, data supported by the study of Boban et al 14 in which the blood ethanol levels of the hospitalized patients analyzed are closer to our data. In addition, about a quarter of the patients who required admission were admitted to the psychiatry department for assessment at this level, 16,22 and not for needing treatment from the organic point of view.…”

Section: Discussionsupporting

confidence: 90%

“…There is a clear predilection for nighttime drinking, as explained in other series analyzed. 1,18 Spring consumption is higher compared with summer, predominant in other publications, and this discrepancy may be attributed to climatic differences with milder temperatures in spring, to the location of the hospital in an area with an aging population and to the lower density of the young population during the summer, due to vacation mobility to the coast.…”

Section: Discussionmentioning

confidence: 79%

“…Excessive alcohol use is a problem that affects society as a whole and, significantly, adolescents. The characteristics of this stage of life, as well as certain external factors, favor access to different toxic substances, including alcohol 1 . The consumption of alcohol associated with other drugs, such as tobacco and cannabis, is related to risk behaviors, antisocial behavior, and even psychiatric disorders in adulthood 2–5 .…”

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confidence: 99%

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Acute Alcohol Intoxication in Pediatric Emergencies

et al. 2022

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IntroductionAlcohol intoxication in pediatrics is a growing problem in our environment. The objectives of this study are to define the prevalence of acute alcohol intoxication in the pediatric emergency department (PED) and to describe the associated symptoms and their relationship with potential risk factors.Methods and MaterialThis cross-sectional study includes patients younger than 16 years with a diagnosis of acute alcohol intoxication between March 2010 and October 2018 in the PED of a tertiary hospital. Patients with concomitant intoxication by other substances were excluded. The association between qualitative variables was determined using the χ2 or Fisher exact test and quantitative with the Student t, Mann-Whitney U test, and simple linear regression.ResultsThere were 136 episodes of alcohol intoxication, which represents a prevalence of 24.1/100,000 emergencies. After excluding 10 patients because of positive screening for other drugs, 126 patients with a mean age of 14.5 years (SD, 1.2 years) were included, 57.9% of whom were women. A total of 25.4% of the patients were younger than 14 years. Ethanolemia was determined in 88.9%, and its mean concentration was 195.7 mg/dL (SD, 56.5 mg/dL), with potentially serious levels (>300 mg/dL) being found in 3.6% of the patients. A relationship was found between the Glasgow Coma Scale score and ethanolemia (B = −12.7; 95% confidence interval, −8.1 to −17.4; P < 0.001), as well as with potassium (B = −31, 9; 95% confidence interval, −6.6 to −57.3; P = 0.014). No patient had seizures or hypoglycemia. A total of 10.3% of the patients required admission.ConclusionsAlcohol intoxication is a rare consultation reason in the PED. They usually present with mild and self-limited symptoms, being the decrease in the level of consciousness and hypokalemia the most frequent symptom and analytical alteration.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 79%

mentioning

confidence: 99%

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Acute Alcohol Intoxication in Pediatric Emergencies

et al. 2022

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“…Además, los usuarios adolescentes normalmente no son conscientes de la gravedad del consumo y tienden a normalizar el uso de sustancias o minimizar las consecuencias del mismo (Matalí Costa et al, 2009); estos hechos pueden reducir la prevalencia observada de patología dual. Dadas las características mencionadas de la adolescencia, la preocupación por el aumento de la prevalencia, la complejidad y la dificultad de detectar la patología dual (Roberts et al, 2007), los servicios de urgencias psiquiátricos infantojuveniles ofrecen una oportunidad para detectar y dirigir este problema (Sanz Marcos et al, 2009).…”

Section: Resumen Adicciones Vol 28 Nº 2 • 2016 Originalunclassified

Adolescents and Dual Diagnosis in a Psychiatric Emergency Service

et al. 2016

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In recent years, both the prevalence of drug use and related child and adolescent psychiatric emergencies have risen sharply. There are few studies about the impact on child and adolescent emergency services. This study has a twofold aim. The first is to describe the prevalence of substance use disorders, mental disorders and dual diagnosis (substance use problems plus mental disorder) in adolescents in psychiatric emergency service. The second is to analyze clinical and healthcare differences between patients with dual diagnosis and patients with a mental disorder without substance use disorder.We retrospectively reviewed 4012 discharge forms for emergencies treated at the psychiatric emergency department during the period 2007-2009. We obtained a sample of 1795 visits. This sample was divided into two groups: the dual diagnosis group (n = 477) and the psychiatric disorder group (n = 1318).The dual diagnosis group accounted for 26.5% of psychiatric emergencies analyzed. Compared to the psychiatric disorder group,the dual diagnosis group had significantly more conduct disorders, social problems, involuntariness in the visit, less hospital admissions and less connection with the healthcare network.Adolescents with a dual diagnosis account for a high percentage of visits at child and adolescent psychiatric emergency services. This patient group requires specialized care both at emergency services and in specific units. Accordingly, these units should play a triple role when handling dual diagnosis: detection, brief treatment and referral to a specialised unit.

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Opposite effects of acute ethanol exposure on GAP-43 and BDNF expression in the hippocampus versus the cerebellum of juvenile rats

Kulkarny

Wiest

Marquez

et al. 2011

Alcohol

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The adolescent brain is particularly vulnerable to the effects of alcohol, with intoxications at this developmental age often producing long-lasting effects. The present study addresses the effects of a single acute ethanol exposure on GAP-43 and BDNF gene expression in neurons in the cerebellum and hippocampus of adolescent rats. Male postnatal day 23 (P23) Sprague-Dawley rats were exposed to ethanol vapors for two hours and after a recovery period of two hours, the cerebellum and hippocampus were harvested and samples were taken for blood alcohol concentration (BAC) determinations. We found that this exposure resulted in a mean BAC of 174 mg/dl, which resembles levels in human adolescents after binge drinking. Analyses of total RNA and protein by qRT-PCR and western blotting, respectively, revealed that this single ethanol exposure significantly decreased the levels of GAP-43 mRNA and protein in the cerebellum but increased the levels of mRNA and protein in the hippocampus. BDNF mRNA and protein levels were also increased in the hippocampus but not in the cerebellum of these animals. In situ hybridizations revealed that GAP-43 and BDNF mRNA levels were primarily increased by alcohol exposure in hippocampal dentate granule cells and CA3 neurons. Overall, the reported alterations in the expression of the plasticity-associated genes GAP-43 and BDNF in juvenile rats are consistent with the known deleterious effects of binge drinking on motor coordination and cognitive function.

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Consultas por intoxicación etílica aguda en un servicio de urgencias pediátricas

Cited by 8 publications

References 10 publications

Acute Alcohol Intoxication in Pediatric Emergencies

Acute Alcohol Intoxication in Pediatric Emergencies

Adolescents and Dual Diagnosis in a Psychiatric Emergency Service

Opposite effects of acute ethanol exposure on GAP-43 and BDNF expression in the hippocampus versus the cerebellum of juvenile rats

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