Consultation rates and characteristics of gastro-oesophageal reflux disease in primary care: A European observational study

Gisbert, Javier P.; Cooper, Alun; Karagiannis, Dimitrios; Hatlebakk, Jan Gunnar; Agréus, Lars; Jablonowski, H; Tafalla, Mónica

doi:10.3109/13814780903260764

Cited by 9 publications

(2 citation statements)

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“…We have previously reported that fullerene derivative 1 induced apoptosis involving the generation of the reactive oxygen species (ROS) in HL60 15. Accordingly, we examined the condensation of nuclear chromatin (Figure 2) and the activation of caspase-3/7 (Figure 3).…”

Section: Resultsmentioning

confidence: 99%

“…We have previously reported that C 60 -bis( N,N -dimethylpyrrolidinium iodide) ( 1 ) (Figure 1) and its analogues exhibited anticancer activity by increasing intracellular oxidative stress and inducing apoptosis 15. In addition, the study using cancer cell line panels which enable evaluation of the antiproliferative activities of a compound in 39 human cancer cell lines suggested that 1 and its analogues are unique anticancer agents with a novel mechanism of action that is different from the mechanisms of existing anticancer drugs such as bleomycin, cisplatin, doxorubicin, etoposide, 5-fluorouracil, paclitaxel, tamoxifen, topotecan, and vincristine 16.…”

Section: Introductionmentioning

confidence: 99%

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<p>Synthesis and antitumor activity of novel pyridinium fullerene derivatives</p>

Yasuno¹,

Ohe²,

Ikeda³

et al. 2019

IJN

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Purpose We have previously reported that some cationic fullerene derivatives exhibited anticancer activity, and they are expected to be a potential lead compound for an anti-drug resistant cancer agent. However, they are bis-adducts and a mixture of multiple regioisomers, which cannot be readily separated due to the variability of substituent positions on the fullerene cage. To overcome this issue, we evaluated the antiproliferative activities of a set of mono-adduct derivatives and examined their structure-activity relationship. In addition, the in vivo antitumor activity of selected derivatives was also examined. Methods Nineteen pyridinium fullerene derivatives were newly designed and synthesized in this study. Their antiproliferative activities were evaluated using several cancer cell lines including drug-resistant cells. Furthermore, in vivo antitumor activity of several derivatives was investigated in mouse xenograft model of human lung cancer. Results The derivatives inhibited the proliferation of cancer cell lines, including cisplatin-resistant cells and doxorubicin-resistant cells. It was also shown that compound 10 (10 μM), 13 (10 μM) and cis - 14 (10 μM) induced the intracellular oxidative stress. In addition, compound 13 (20 mg/kg) and cis - 14 (15 mg/kg) significantly exhibited antitumor activity in mouse xenograft model of human lung cancer. Conclusion We synthesized a novel set of mono-adduct fullerene derivatives functionalized with pyridinium groups and found that most of them show potent antiproliferative activities against cancer cell lines and some of them show significant antitumor activities in vivo. We propose that these fullerene derivatives serve as the lead compounds for a novel type of antitumor agents.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Synthesis and antitumor activity of novel pyridinium fullerene derivatives</p>

Yasuno¹,

Ohe²,

Ikeda³

et al. 2019

IJN

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Nanoantibiotic effect of carbon-based nanocomposites: epicentric on graphene, carbon nanotubes and fullerene composites: a review

et al. 2023

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A proline-type fullerene derivative inhibits adipogenesis by preventing PPARγ activation

Funakoshi‐Tago

Hattori

Ueda

et al. 2016

Biochemistry and Biophysics Reports

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Obesity and its associated metabolic diseases represent some of the most rapidly expanding health issues worldwide, and, thus, the development of a novel chemical compound to suppress adipogenesis is strongly expected. We herein investigated the effects of water-soluble fullerene derivatives: a bis-malonic acid derivative and three types of proline-type fullerene derivatives, on adipogenesis using NIH-3T3 cells overexpressing PPARγ. One of the proline-type fullerene derivatives (P3) harboring three carboxy groups significantly inhibited lipid accumulation and the expression of adipocyte-specific genes, such as aP2, induced by the PPARγ agonist rosiglitazone. On the other hand, the bis-malonic acid derivative (M) and the 2 other proline-type fullerene derivatives (P1, P2), which have two carboxy groups, had no effect on PPARγ-mediated lipid accumulation or the expression of aP2. P3 fullerene also inhibited lipid accumulation induced by the combined stimulation with 3-isobutyl-1-methylxanthine (IBMX), dexamethasone, and insulin in 3T3-L1 preadipocytes. During the differentiation of 3T3-L1 cells into adipocytes, P3 fullerene did not affect the expression of C/EBPδ, C/EBPβ, or PPARγ, but markedly inhibited that of aP2 mRNA. These results suggest that P3 fullerene exhibits anti-obesity activity by preventing the activation of PPARγ.

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Consultation rates and characteristics of gastro-oesophageal reflux disease in primary care: A European observational study

Cited by 9 publications

References 0 publications

<p>Synthesis and antitumor activity of novel pyridinium fullerene derivatives</p>

<p>Synthesis and antitumor activity of novel pyridinium fullerene derivatives</p>

Nanoantibiotic effect of carbon-based nanocomposites: epicentric on graphene, carbon nanotubes and fullerene composites: a review

A proline-type fullerene derivative inhibits adipogenesis by preventing PPARγ activation

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