Spices and condiments, in addition to imparting seasoning they also possess medicinal values. The essential oils are the active principles of the condiments and spices. The combination of numerous essential oil fractions, not only enhances the values of the food as appetizers by imparting fragrances but also accredit the therapeutic values when used in the cooking. Spices such as Cinnamon, Cloves, Black pepper are enriched in essential oils with pharmaceutically active compounds like cinnamaldehyde, eugenol, and piperine. Similarly, condiments like Coriander, Chili, Cumin, are recognized for constituents like allicin, curcumin, linalool, etc. These components hold antioxidants properties and for many diseases, works as naturally occurring defensive constituents. This work is intended to outline the medicinal potential of commonly used spices and condiments based on the findings and reports of recent research across South Asian countries where spices and condiments form chief flavoring components of traditional foods.