In recent decades, the global increase in the demand for food and the increasing growth of the world population has caused an inevitable transition from traditional to advanced agriculture and the use of new technologies in the production of food and agricultural products. One of the new achievements of biotechnology is the production and use of genetically modified plants. The benefits of genetically modified crops can be seen well beyond the farm as well, from helping to conserve natural resources to fighting climate change. Identifying the factors that influence people’s acceptance of genetically modified (GM) foods can inform industries and policymakers regarding their innovation trajectories, as well as policy development and implementation. Therefore, the current research evaluates the effect of the marketing mix and other effective factors on the consumption of genetically modified (GM) edible oil in Mashhad, Iran. The required information was collected by completing 390 questionnaires and using the available sampling method in 2022. Factors affecting the probability of consumers making a decision to consume GM edible oil and the consumption amounts of this oil were analyzed through Heckman’s two-stage Tobit model using the STATA 16 software package. The results showed that factors affecting the intention of consuming GM edible oils are different from factors affecting the amount of consumption of GM edible oils. Moreover, selected marketing mixes have a significant effect on the amount of consumption of GM edible oils, and therefore, policy-makers can influence the consumption of GM edible oils by using marketing tools. The effect of household monthly income on the consumption of GM edible oil is also negative and significant, which shows that households with higher incomes have less consumption of GM edible oils. Based on the results, trust in the government has a positive and significant effect on the consumption of GM edible oil, so when consumers have trust in their government about GM food products, the consumption of GM edible oil will increase. Therefore, it is suggested that the country’s food security authorities gain the trust of consumers by clarifying the production process of GM products and holding scientific debates between the proponents and opponents of the production and consumption of GM food products in order to express the advantages and disadvantages of these products to inform consumers and help them choose between products.