The garment manufacturing industry is a labor-intensive industry, with one of the slowest transitions to automation. Hence, it is essential to build a smart factory based on automated systems to improve productivity and allow responsive production in the market. In this study, the manufacturing processes for a smart sports bra were established and optimized using various automated machines. For this system, computer-based 3D virtual design software, a technical embroidery machine, an automatic cutting machine, an industrial robot arm with gripper, and an industrial pattern sewing machine were used. The design and materials of the sports bra were selected considering embroidery, cutting, robot gripping, and sewing processes. In addition, conductive thread and light-emitting diode (LED) sequences were used to implement smart functions to the sports bra. Transport of intermediate materials, work orders, and process conditions were optimized to improve the flexible connection of each process and the quality of the final product. This study suggests the concept of the automated manufacturing system that minimizes human intervention by connecting the processes needed to produce a smart sports bra using various automation equipment and programs already used in the industry.