2020
DOI: 10.1016/j.jdiacomp.2020.107557
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Consuming a ketogenic diet leads to altered hypoglycemic counter-regulation in mice

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Cited by 12 publications
(14 citation statements)
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“…Under starvation, the stored fat is progressively shed to last as much as feasible; our bodies adapt to lower energy, lower carbohydrate and limited protein intake diets, including the absence of fats, following the blueprints for starvation [ 212 ]. The elimination of dietary carbohydrates [ 213 , 214 ] and lowering of energy intake share some characteristics, because of our adaptability to starvation, but there is a considerable discussion on the proposed benefits of ketogenic diets, which, in any case, could not be generalized from epilepsy to obesity [ 215 , 216 , 217 ]. Nevertheless, even after prolonged starvation or removal of dietary carbohydrates, a significant portion of body fat remains, even after prolonged exposure.…”
Section: Normalization and Regulation Under Excess (If Any)mentioning
confidence: 99%
“…Under starvation, the stored fat is progressively shed to last as much as feasible; our bodies adapt to lower energy, lower carbohydrate and limited protein intake diets, including the absence of fats, following the blueprints for starvation [ 212 ]. The elimination of dietary carbohydrates [ 213 , 214 ] and lowering of energy intake share some characteristics, because of our adaptability to starvation, but there is a considerable discussion on the proposed benefits of ketogenic diets, which, in any case, could not be generalized from epilepsy to obesity [ 215 , 216 , 217 ]. Nevertheless, even after prolonged starvation or removal of dietary carbohydrates, a significant portion of body fat remains, even after prolonged exposure.…”
Section: Normalization and Regulation Under Excess (If Any)mentioning
confidence: 99%
“…In non-obese, non-diabetic rodent studies, LCD and KD feeding often results in significantly lower fasted glucose than rodents on a chow diet [ 34 , 57 , 58 , 59 , 60 ], or no different than chow or low-fat diet [ 33 , 35 , 61 , 62 ] and improved compared to obesogenic HFDs. Fed state glucose was also decreased in KD compared to chow-fed mice [ 61 ]; however, it was not different than chow-fed rats [ 37 , 63 ].…”
Section: Islet Hormone Secretionmentioning
confidence: 99%
“…Fed state glucose was also decreased in KD compared to chow-fed mice [ 61 ]; however, it was not different than chow-fed rats [ 37 , 63 ]. When challenged with systemic (insulin tolerance test) or neural hypoglycemia, mice on the KD for 7 days had significantly lower glucagon and blood glucose compared to chow-fed mice, indicating reduced protection for hypoglycemic events [ 60 ]. Jornayvaz et al similarly found that mice fed a KD had decreased fasted glucagon compared to chow-fed mice [ 59 ], whereas in another study, KD mice had similar fed glucagon to weight matched, chow-fed controls [ 61 ].…”
Section: Islet Hormone Secretionmentioning
confidence: 99%
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“…Previous studies in KD-fed nondiabetic mice reported an impairment in glucagon secretion in response to insulin-induced hypoglycemia [ 21 ]. Although acute administration of glucagon to hypoglycemic type 1 diabetes patients is an effective treatment to stimulate endogenous glucose production, its role in the endogenous CRR in type 1 diabetes is limited due to pancreatic alpha- and beta-cell failure.…”
Section: Introductionmentioning
confidence: 99%