Consuming High-Carotenoid Fruit and Vegetables Influences Skin Yellowness and Plasma Carotenoids in Young Women: A Single-Blind Randomized Crossover Trial

Pezdirc, Kristine; Hutchesson, Melinda J.; Williams, Rebecca; Rollo, Megan E.; Burrows, Tracy; Wood, Lisa G.; Oldmeadow, Christopher; Collins, Clare E.

doi:10.1016/j.jand.2016.03.012

Cited by 44 publications

(35 citation statements)

References 20 publications

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“…Introduction β-Carotene is a tetra-terpenoid consisting of a C40 structure including two β-ionone rings. Together with lycopene, it is among the most frequently consumed dietary carotenoids in human subjects (1)(2)(3) , also ranking among the highest in blood / plasma concentrations (3,4) . β-Carotene is the most important source of nonpreformed vitamin A, as this molecule can, following absorption, be cleaved to form vitamin A (retinal).…”

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confidence: 99%

β-Carotene in the human body: metabolic bioactivation pathways – from digestion to tissue distribution and excretion

et al. 2019

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5Paprika Bioanalytics BT, Debrecen, Hungary β-Carotene intake and tissue/blood concentrations have been associated with reduced incidence of several chronic diseases. Further bioactive carotenoid-metabolites can modulate the expression of specific genes mainly via the nuclear hormone receptors: retinoic acid receptor-and retinoid X receptor-mediated signalling. To better understand the metabolic conversion of β-carotene, inter-individual differences regarding β-carotene bioavailability and bioactivity are key steps that determine its further metabolism and bioactivation and mediated signalling. Major carotenoid metabolites, the retinoids, can be stored as esters or further oxidised and excreted via phase 2 metabolism pathways. In this review, we aim to highlight the major critical control points that determine the fate of β-carotene in the human body, with a special emphasis on β-carotene oxygenase 1. The hypothesis that higher dietary β-carotene intake and serum level results in higher β-carotene-mediated signalling is partly questioned. Alternative autoregulatory mechanisms in β-carotene / retinoid-mediated signalling are highlighted to better predict and optimise nutritional strategies involving βcarotene-related health beneficial mediated effects.

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confidence: 99%

β-Carotene in the human body: metabolic bioactivation pathways – from digestion to tissue distribution and excretion

et al. 2019

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“…The effect of carotene intake on skin color is still under debate because contradicting results were observed from having an impact only on skin yellowness b* [36, 37] and or redness a* [38]. …”

Section: Resultsmentioning

confidence: 99%

Tomato Phytonutrients Balance UV Response: Results from a Double-Blind, Randomized, Placebo-Controlled Study

Groten

Marini

Jaenicke

et al. 2019

Skin Pharmacol Physiol

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Background: Our previous double-blinded, placebo-controlled cross-over study indicated that a nutritional supplement named lycopene-rich tomato nutrient complex (TNC) can protect from UVA1-induced (340–400 nm) and UVA- (320–400 nm)/UVB-induced (280–320 nm) upregulation of molecular markers associated with oxidative stress, inflammation, and ageing. Objectives: in the current double-blind, randomized, placebo-controlled multicenter study, we analyze whether a similar, synergistic carotenoid-rich TNC can protect from broadband UVB-induced threshold erythema formation assessed as increase in minimal erythemal dose (MED) reading, the intensity of erythema formation, and the upregulation of molecular markers associated with inflammation and immunosuppression, and whether this correlates with carotenoid blood levels. Methods: One hundred and forty-nine healthy volunteers were randomized to two groups and subjected to a 5-week washout phase, followed by a 12-week treatment phase receiving either 15 mg lycopene, 5.8 mg phytoene and phytofluene, 0.8 mg β-carotene, 5.6 mg tocopherols from tomato extract, and 4 mg carnosic acid from rosemary extract per day or placebo made from medium-chain triglycerides. At the end of each phase, MED determination, UVB irradiation, chromametry, biopsies, and blood samples were undertaken. Results: The active supplement was well tolerated. Interestingly, no significant difference was seen in the MED between the active-supplement and placebo groups, as determined by visual grading by expert assessors. Of note, the carotenoid-containing supplement significantly protected against UVB-induced erythema formation measured as Δa* after the intervention minus Δa* after the washout phase as compared to the placebo. Moreover, intake of the active supplement significantly protected against UVB-induced upregulation of IL6 and TNFα as compared with the intake of placebo. Lastly, carotenoid plasma levels were significantly increased. Conclusion: This well-tolerated carotenoid-containing supplement significantly protected against UVB-induced erythema formation and upregulation of proinflammatory cytokines in healthy volunteers.

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“…Skin color is affected by the redox status of hemoglobin and blood perfusion (Stamatas & Kollias, ) which produces a flushed or pale skin appearance when increased or decreased, respectively. It is affected also by carotene, which is an orange‐yellow pigment that accumulates in epidermal cells and fatty tissue of the dermis upon consumption of carotene‐rich food such as carrots and oranges (Pezdirc et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…tissue of the dermis upon consumption of carotene-rich food such as carrots and oranges (Pezdirc et al, 2016).…”

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confidence: 99%

Dyspigmented hypertrophic scars: Beyond skin color

Alkhalil

Carney

Travis

et al. 2019

Pigment Cell Melanoma Res

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Although pigment synthesis is well understood, relevant mechanisms of psychologically debilitating dyspigmentation in nascent tissue after cutaneous injuries are still unknown. Here, differences in genomic transcription of hyper‐ and hypopigmented tissue relative to uninjured skin were investigated using a red Duroc swine scar model. Transcription profiles differed based on pigmentation phenotypes with a trend of more upregulation or downregulation in hyper‐ or hypopigmented scars, respectively. Ingenuity Pathway Analysis of significantly modulated genes in both pigmentation phenotypes showed pathways related to redox, metabolic, and inflammatory responses were more present in hypopigmented samples, while those related to stem cell development differentiation were found mainly in hyperpigmented samples. Cell–cell and cell–extracellular matrix interactions and inflammation responses were predicted (z‐score) active in hyperpigmented and inactive in hypopigmented. The proinflammatory high‐mobility group box 1 pathway showed the opposite trend. Analysis of differentially regulated mutually exclusive genes showed an extensive presence of metabolic, proinflammatory, and oxidative stress pathways in hypopigmented scars, while melanin synthesis, glycosaminoglycans biosynthesis, and cell differentiation pathways were predominant in hyperpigmented scar. Several potential therapeutic gene targets have been identified.

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Consuming High-Carotenoid Fruit and Vegetables Influences Skin Yellowness and Plasma Carotenoids in Young Women: A Single-Blind Randomized Crossover Trial

Cited by 44 publications

References 20 publications

β-Carotene in the human body: metabolic bioactivation pathways – from digestion to tissue distribution and excretion

β-Carotene in the human body: metabolic bioactivation pathways – from digestion to tissue distribution and excretion

Tomato Phytonutrients Balance UV Response: Results from a Double-Blind, Randomized, Placebo-Controlled Study

Dyspigmented hypertrophic scars: Beyond skin color

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