Consumo de ácido fólico en el embarazo y reducción del riesgo de trastornos del espectro autista

Rangel-Rivera, Diego Alejandro; Osma-Zambrano, Sonia Esperanza

doi:10.18273/revmed.v28n3-2015007

Cited by 2 publications

(3 citation statements)

References 61 publications

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“…Rangel-Rivera et al 16 2015 Colombia Folic acid remains a major ally against structural defects of the central nervous system. There are aspects that affirm its protective effect in relation to ASD, but this study is inconclusive to affirm its protection.…”

Section: Strøm Et Al 22 2018 Denmarkmentioning

confidence: 99%

“…This requires intensified studies to discover the relationship of nutrition in different populations and the association with food fortification and additional FA supplementation. 15,16 The increase in the number of ASD cases may be linked to several factors, such as changing diagnostic criteria, increased information, and excess FA consumed by women of childbearing age. 17 Supplementation with periconceptional FA reduced neural tube defects by up to 70% and resulted in fortification of cereal products in several countries.…”

Section: Inconclusive Association Between Folic Acid Consumption and Autism Spectrum Disordermentioning

confidence: 99%

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Association of the Maternal Folic Acid Supplementation with the Autism Spectrum Disorder: A Systematic Review

Sampaio

Neto

Lopes

et al. 2021

Rev Bras Ginecol Obstet

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Objective To analyze the scientific production regarding maternal folic acid (FA) supplementation and its relationship with autistic spectrum disorder (ASD). Data Sources We performed unrestricted electronic searches in the BIREME virtual bank, Virtual Health Library (VHL) and Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed) databases. Selection of Studies For sample selection, articles that met the proposed objectives were included, published in English, Spanish and Portuguese, the use of Health Sciences Descriptors (DeCS): autistic OR autism AND autism spectrum disorder AND folic acid, AND, with the use of the Medical Subject Headings (MeSH): autistic OR autism AND autistic spectrum disorder AND folic acid. Data Collection Data extraction was performed by the reviewers with a preestablished data collection formulary. Data Synthesis The Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) was used based on a checklist with 27 items and a 4-step flowchart. Results A total of 384 articles was found by the search strategies, of which 17 were eligible following the pre-established criteria. The main findings of the present review point to maternal FA supplementation in the pre-conception period and beginning of pregnancy as a protective effect in relation to ASD, which should be indicated in this period as prevention to the problem. Conclusion According to the research analyzed, more studies are necessary to know its effects on pregnancy, since the consumption of excessive FA may not be innocuous.

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Section: Strøm Et Al 22 2018 Denmarkmentioning

confidence: 99%

Section: Inconclusive Association Between Folic Acid Consumption and Autism Spectrum Disordermentioning

confidence: 99%

Association of the Maternal Folic Acid Supplementation with the Autism Spectrum Disorder: A Systematic Review

Sampaio

Neto

Lopes

et al. 2021

Rev Bras Ginecol Obstet

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“… 16 Such vitamin has a fundamental role on cell proliferation, interfering in erythrocyte increasing, uterus enlargement, and development of both placenta and fetus, 17 becoming indispensable during pregnancy. According to Rangel-Rivera and Osma-Zambrano, 18 FA is essential for suitable formation and maintenance of several structures of the central nervous system, reducing the risk of severe language and attention disorders, schizophrenia, pre-eclampsia, low birth weight and premature birth. Meroanencephaly and spina bifida are the most common severe congenital malformations and both stem from defects of neural tube closure, can be prevented by FA intake in early gestation and immediately before such period.…”

Section: Introductionmentioning

confidence: 99%

Impact of Maternal Folic Acid Supplementation on Descendants' Kidney in Adulthood

Fernandes

Conde

Brasil

et al. 2023

Rev Bras Ginecol Obstet

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Supplementation with folic acid (FA) during gestation has been recommended by medical society all over the world, but some studies have shown that intake of high folic acid diet may unleash damages to the descendants. Objectives: Describing the effects of maternal supplementation with FA during gestation on offspring's kidney at late life stages. Data Source: It is a systematic review by which were consulted the following databases: Medline, through Pubmed, Lilacs, and SciELO. The research was performed using the keywords “Folic acid”, “Gestation” and “Kidney”. Study Selection: Eight studies were regarded for this systematic review. Data Collection: Only studies that evaluated folic acid consumption during gestation and its effects exclusively on descendants' kidney at several phases of life were regarded. Results: Gestational FA intake did not change the renal volume, glomerular filtration rate and the expression of some essential genes in the kidney of puppies whose dams were supplemented with FA. Maternal consumption of double FA plus selenium diet was effective in preserving antioxidant enzymes activity in the kidney of descendants from mothers exposed to alcohol. FA supplementation decreased some gross anomalies in the puppies caused by teratogenic drug despite of had not been effective in preventing some renal architectural damages. Conclusion: FA supplementation did not cause renal toxicity; it exerted an antioxidant protective effect and mitigated some renal disorders caused by severe aggressions.

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Consumo de ácido fólico en el embarazo y reducción del riesgo de trastornos del espectro autista

Cited by 2 publications

References 61 publications

Association of the Maternal Folic Acid Supplementation with the Autism Spectrum Disorder: A Systematic Review

Association of the Maternal Folic Acid Supplementation with the Autism Spectrum Disorder: A Systematic Review

Impact of Maternal Folic Acid Supplementation on Descendants' Kidney in Adulthood

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