Consumption Coagulopathy in Congenital Heart-Disease

Ihenacho, H. N. C.; Breeze, G R; Fletcher, Daniel J.; Stuart, J.

doi:10.1016/s0140-6736(73)90069-x

Cited by 41 publications

(13 citation statements)

References 11 publications

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“…Platelet survival studies in adult sickle-cell patients have shown significantly prolonged survival during asymptomatic periods compared with that in healthy controls (Haut, Cowan, and Harris, 1973). In contrast, the present study in children (mean age 7-6 years) has not shown a significant increase (p > 0-05) in the mean platelet count during asymptomatic periods compared with the mean value for hospital control patients admitted for elective surgical procedures (Ihenacho, Breeze, Fletcher, and Stuart, 1973). The older adolescent and the adult patient with sickle-cell anaemia has usually undergone splenic atrophy due to recurrent microinfarction (Diggs, 1963); the thrombocytosis of older patients may therefore be a consequence of autosplenectomy in contrast with the presumed better splenic function and normal platelet counts of our younger patients.…”

Section: Resultscontrasting

confidence: 99%

Coagulation fibrinolysis in sickle-cell disease

et al. 1974

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SYNOPSIS A study of fibrinolytic activity in sickle-cell patients during asymptomatic periods has shown a normal fibrinolytic response to exercise and local heat to the arm. During vasoocclusive crises there was no significant decrease in fibrinolytic activity. These results contrast with earlier reports of decreased fibrinolysis during crisis and a suggestion that fibrinolytic activators might be of value in preventing vasoocclusive episodes.Patients in painful crisis showed a significant rise in fibrinogen concentration and fall in platelet count. The former may contribute to localized vascular sludging by increasing whole-blood viscosity, while the latter probably results from local trapping of platelets in areas of sickling or from subsequent splenic sequestration of damaged platelets. There was no evidence of disseminated, as opposed to localized, intravascular coagulation during crisis.

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Section: Resultscontrasting

confidence: 99%

Coagulation fibrinolysis in sickle-cell disease

et al. 1974

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“…Though we do not consider our findings as conclusive, we find it noteworthy that recent studies have suggested that a consumption coagulopathy may occur in certain cyanotic patients (Ihenacho et al, 1973).…”

Section: Discussioncontrasting

confidence: 87%

Primary thrombosis of pulmonary artery in a child with tetralogy of Fallot.

Svane¹

1977

Heart

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A 34-month-old child with tetralogy of Fallot developed an acute, primary thrombosis of the pulmonary trunk. A greatly increased haematocrit was most probably a predisposing factor. An unusual postmortem finding was the large number of extremely dilated myocardial capillaries. In a review of a series of 394 consecutive necropsy cases with many kinds of cardiac anomalies, there was only one case (a 28-year-old man) with occluding thrombus formation in the pulmonary artery. This case also belonged to the Fallot group but a subacute glomerulonephritis seemed to be the major cause of death.

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“…• Increased coagulation [146][147][148][149][150][151] • Increased or decreased fibrinolysis 146,147,152 • Increased or decreased platelet numbers and function 146,148,153,154 • Other factors: endothelial vascular damage resulting from placement of a central line, CPB, ECMO…”

Section: Propensity To Coagulopathy In Children With Heart Diseasementioning

confidence: 99%