Consumption evaluation of one apple flesh a day in the initial phases prior to adenoma/adenocarcinoma in an azoxymethane rat colon carcinogenesis model

Bars-Cortina, David; Martínez-Bardají, Ana; Macià, Alba; Motilva, María‐José; Piñol-Felis, Carme

doi:10.1016/j.jnutbio.2020.108418

Cited by 21 publications

(20 citation statements)

References 69 publications

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“…The anthocyanin extract from purple-shoot tea [69], curly kale [70], Chinese eggplant [71], and Pistacia atlantica sub kurdica [72], and apple [73] showed antitumor effects in cell lines or carcinogenesis animal models. The antitumor effects are associated with cell proliferation inhibition, apoptosis induction, cell migration inhibition, cell cycle arrest, DNA damage protection, and antioxidation.…”

Section: Other Fruits and Vegetablesmentioning

confidence: 99%

Anthocyanins in Colorectal Cancer Prevention Review

Shi

Chen

2021

Antioxidants

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Colorectal cancer (CRC) is still a big health burden worldwide. Nutrition and dietary factors are known to affect colorectal cancer development and prognosis. The protective roles of diets rich in fruits and vegetables have been previously reported to contain high levels of cancer-fighting phytochemicals. Anthocyanins are the most abundant flavonoid compounds that are responsible for the bright colors of most blue, purple, and red fruits and vegetables, and have been shown to contribute to the protective effects of fruits and vegetables against cancer and other chronic diseases. Berries and grapes are the most common anthocyanin-rich fruits with antitumor effects. The antitumor effects of anthocyanins are determined by their structures and bioavailability as well as how they are metabolized. In this review, we aimed to discuss the preventive as well as therapeutic potentials of anthocyanins in CRC. We summarized the antitumor effects of anthocyanins and the mechanisms of action. We also discussed the potential pharmaceutical application of anthocyanins in practice.

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Section: Other Fruits and Vegetablesmentioning

confidence: 99%

Anthocyanins in Colorectal Cancer Prevention Review

Shi

Chen

2021

Antioxidants

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“…[ 16 ] Indeed, red‐fleshed apple supplementation in rats has already shown protective effects against colon carcinogenesis retarding/diminishing the appearance of the precancerous markers and the expression of genes related to this cancer. [ 17 ]…”

Section: Introductionmentioning

confidence: 99%

Metabolic Fate and Cardiometabolic Effects of Phenolic Compounds from Red‐Fleshed Apple in Hypercholesterolemic Rats: A Comparative Study with Common White‐Fleshed Apple. The AppleCOR Study

Yuste

Ludwig

Romero

et al. 2021

Molecular Nutrition Food Res

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The present study aims to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds provided by a red-fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats are fed with high-fat diet (HFD) to induce hypercholesterolemia and supplemented with red-fleshed apple (HFD+R), white-fleshed apple (HFD+W), or an ACN-rich infusion from aronia fruit (HFD+A) providing matched content and profile of ACN. Plasma biochemical parameters, histological analysis, and phenol biological metabolites are determined. Plasma, urine, and feces show a significant increase of ACN metabolites after HFD+R and HFD+A, while flavan-3-ols are significantly increased after HFD+W and dihydrochalcones derivatives increased after both apples supplementation. A cardioprotective effect is observed after both apples and aronia infusion supplementation in the reduction of aortic thickness. The kidney function is improved after all supplementations and a decrease in insulin plasma concentration after both apples supplementation (HFD+R and HFD+W) is also observed. The findings support that ACN without apple matrix can induce cardioprotective effects. ACN or flavan-3-ols, together with dihydrochalcones, compose a phenolic phytocomplex in red-and white-fleshed apples, respectively, which can act synergistically in the attenuation of cardiovascular outcomes in hypercholesterolemic rats.

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“…"Fruits and vegetables are important components of a healthy diet", and their daily consumption reduces the risk of severe illnesses, such as cardiovascular diseases and certain types of cancer [1,2]. Despite these scientifically validated health benefits, contaminated produce (by virus, bacteria, or parasites) has been linked to major cases and outbreaks of foodborne diseases in recent years, and has led to some of the biggest food recalls [3,4].…”

Section: Introductionmentioning

confidence: 99%

Microbiological and Chemical Quality of Portuguese Lettuce—Results of a Case Study

Ferreira

Lopes

Costa

et al. 2020

Foods

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In addition to environmental pollution issues, social concerns about the sustainability, safety, and quality of conventionally grown fruits and vegetables have been increasing. In order to evaluate if there were any microbiological differences between samples of organic and conventional lettuce, a wide range of parameters were tested, including pathogens and indicator organisms: the enumeration of Escherichia coli; the detection of Salmonella spp.; the detection/enumeration of Listeria monocytogenes; the enumeration of lactic acid bacteria, Pseudomonas spp. yeasts and molds, and Enterobacteriaceae. This study also evaluated the chemical safety of the lettuce samples, quantifying the nitrate concentration and 20 pesticides (14 organochlorine and 6 organophosphorus pesticides). Significant differences (p < 0.05) between the conventional and organic samples were only detected for the counts of total microorganisms at 30 °C. Pathogens were absent in all the samples. The analytical method, using the quick, easy, cheap, effective, rugged, and safe (QuEChERS) approach for pesticide extraction, was suitable for detecting the targeted analytes; the limit of quantification (LOQ) was between 0.6 and 1.8 µg/kg (lower than the Maximum Residue Levels (MRLs) established by EU legislation). In three organic lettuce samples, one organochlorine pesticide (α-HCH) was observed below the MRLs. For the samples analyzed and for the parameters investigated, except for the total mesophilic counts, the organic and conventional lettuces were not different.

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Consumption evaluation of one apple flesh a day in the initial phases prior to adenoma/adenocarcinoma in an azoxymethane rat colon carcinogenesis model

Cited by 21 publications

References 69 publications

Anthocyanins in Colorectal Cancer Prevention Review

Anthocyanins in Colorectal Cancer Prevention Review

Metabolic Fate and Cardiometabolic Effects of Phenolic Compounds from Red‐Fleshed Apple in Hypercholesterolemic Rats: A Comparative Study with Common White‐Fleshed Apple. The AppleCOR Study

Microbiological and Chemical Quality of Portuguese Lettuce—Results of a Case Study

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