Consumption of animal foods and endometrial cancer risk: a systematic literature review and meta-analysis

Bandera, Elisa V.; Kushi, Lawrence H.; Moore, Dirk F.; Gifkins, Dina; McCullough, Marjorie L.

doi:10.1007/s10552-007-9038-0

Cited by 82 publications

(70 citation statements)

References 41 publications

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“…Interpretation of the evidence may not represent the views of WCRF and may differ from those in the upcoming 2007 WCRF/AICR report summarizing evidence related to food, nutrition, physical activity, and cancer risk. Exposure terms and methods can be found in the appendix of another manuscript (Bandera et al, 2007a …”

Section: Methodsmentioning

confidence: 99%

Vitamin D and calcium intake in relation to risk of endometrial cancer: A systematic review of the literature

McCullough¹,

Bandera²,

Moore³

et al. 2008

Preventive Medicine

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Objective-In response to a recent ecologic study of UV exposure and endometrial cancer incidence, we present the epidemiologic evidence on the relation between intake of vitamin D and its metabolically related nutrient, calcium, and the occurrence of endometrial cancer.Methods-We conducted a systematic literature review and meta-analysis of vitamin D and calcium in relation to endometrial cancer, including peer-reviewed manuscripts published up to May 2007. Random and fixed effects summary estimates were computed.Results-Pooled analyses of the three case-control studies of dietary vitamin D and endometrial cancer uncovered heterogeneous results that were not significant in random or fixed effects analyses. Cut-points for the highest vitamin D intakes ranged from >244 to >476 IU/day. Qualitatively similar findings were observed for dietary calcium. Only two studies provided estimates for calcium supplements (random effects OR=0.62, 95% CI 0.39-0.99; fixed effects OR=0.62, 95% CI 0.42-0.93, for top vs bottom category, p for heterogeneity=0.25).Conclusions-The limited epidemiological evidence suggests no relation between endometrial cancer in the ranges of dietary vitamin D examined, and suggests a possible inverse association for calcium from supplements. Prospective studies, ideally including plasma 25(OH) D to estimate vitamin D input from diet and sun exposure, are needed to further explore these hypotheses.

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Section: Methodsmentioning

confidence: 99%

Vitamin D and calcium intake in relation to risk of endometrial cancer: A systematic review of the literature

McCullough¹,

Bandera²,

Moore³

et al. 2008

Preventive Medicine

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“…Dairy products in general and milk in particular, have also been examined in relation to cancer risk. Among women, consumption of milk may decrease risk of colorectal cancer (1) and cervical cancer (2), but have no effect on breast cancer e.g., (3)-4) or endometrial cancer (4). Results for lung cancer are quite mixed, with some studies suggesting risk reduction e.g., (5) or risk enhancement e.g., (6) that may vary by gender (7) or the histology of the tumor (8).…”

Section: Introductionmentioning

confidence: 99%

Unpasteurized milk consumption and subsequent risk of cancer

Sellers

Vierkant

Djeu

et al. 2008

Cancer Causes Control

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Concerns have been raised regarding the possible adverse health effects of consumption of unpasteurized milk and risk of cancer. We examined the association of self-reported intake of unpasteurized milk with subsequent risk of cancer in a large population-based cohort study. The Iowa Women's Health Study is a prospective cohort study of 55-69 year old women at baseline in 1986. Of the 41,836 women in the cohort at baseline, 22,808 cancer-free women completed the fourth follow-up questionnaire in 1997. Risk ratios (RR) and 95% confidence intervals (CI) were calculated using Cox proportional hazards regression analysis. Reported intake of unpasteurized milk was high: 59.2% consumed only as a child, 2.5% consumed only as an adult, and 16.5% consumed as a child and an adult. A total of 2,379 cancers were identified in the cohort at risk. Overall, the age-adjusted risk of cancer was lower among women who reported consumption of unpasteurized milk only as a child (RR = 0.90, 95% CI: 0.82-0.99) or as a child and an adult (RR = 0.85; 95% CI: 0.75-0.97). Adjustment for confounding factors attenuated these associations (RR = 0.92, 95% CI: 0.83-1.02 for consumption only as a child, and RR = 0.91; 95% CI: 0.79-1.04 for consumption as a child and an adult). These data suggest that consumption of unpasteurized milk does not increase risk of cancer.

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“…Alternatively, the highest sources of cholesterol among food groups in our questionnaire were, as expected, red meat (including higher fat beef, veal and pork), eggs, poultry and high-fat dairy. Hence, the increased risk with cholesterol may also reflect intake of animal foods that also increase EC risk (47) . Numerous observational studies have reported on the influence of dietary micronutrients in EC aetiology (5,6,20,21,(23)(24)(25)(26)28,30,31,34,(48)(49)(50)(51)(52)(53) ; two were cohort studies (6,48) and the rest were case-control studies.…”

Section: Discussionmentioning

confidence: 99%

Risk of endometrial cancer in relation to individual nutrients from diet and supplements

Biel

Csizmadi

Cook

et al. 2011

Public Health Nutr.

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Objective: Intake of nutrients may influence the risk of endometrial cancer (EC). We aimed to estimate the association of intake of individual nutrients from food and from food plus supplements with EC occurrence. Design: A population-based case-control study conducted in Canada (2002Canada ( -2006. Setting: Nutrient intakes from food and supplements were assessed using an FFQ. Logistic regression was used to estimate EC risk within quartile levels of nutrient intakes. Subjects: Incident EC cases (n 506) were identified from the Alberta Cancer Registry, and population controls were frequency-and age-matched to cases (n 981). Results: There existed little evidence of an association with EC for the majority of macronutrients and micronutrients examined. We observed a statistically significant increased risk associated with the highest, compared with the lowest, quartile of intake of dietary cholesterol (multivariable-adjusted OR 5 1?51, 95 % CI 1?08, 2?11; P for trend 5 0?02). Age-adjusted risk at the highest level of intake was significantly reduced for Ca from food sources (OR 5 0?73, 95 % CI 0?54, 0?99) but was attenuated in the multivariable model (OR 5 0?82, 95 % CI 0?59, 1?13). When intake from supplements was included in Ca intake, risk was significantly reduced by 28 % with higher Ca (multivariable-adjusted OR 5 0?72, 95 % CI 0?51, 0?99, P for trend 5 0?04). We also observed unexpected increased risks at limited levels of intakes of dietary soluble fibre, vitamin C, thiamin, vitamin B 6 and lutein/zeaxanthin, with no evidence for linear trend. Conclusions: The results of our study suggest a positive association between dietary cholesterol and EC risk and an inverse association with Ca intake from food sources and from food plus supplements.

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Consumption of animal foods and endometrial cancer risk: a systematic literature review and meta-analysis

Cited by 82 publications

References 41 publications

Vitamin D and calcium intake in relation to risk of endometrial cancer: A systematic review of the literature

Vitamin D and calcium intake in relation to risk of endometrial cancer: A systematic review of the literature

Unpasteurized milk consumption and subsequent risk of cancer

Risk of endometrial cancer in relation to individual nutrients from diet and supplements

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