Consumption of Dairy Yogurt Containing Lactobacillus paracasei ssp. paracasei, Bifidobacterium animalis ssp. lactis and Heat-Treated Lactobacillus plantarum Improves Immune Function Including Natural Killer Cell Activity

Lee, Ayoung; Lee, Young Ju; Yoo, Hye Jin; Kim, Minkyung; Chang, Young‐Wook; Lee, Dong Seog; Lee, Jong Ho

doi:10.3390/nu9060558

Cited by 94 publications

(88 citation statements)

References 27 publications

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“…extensively used as active ingredients in a variety of functional foods (14,15). The B. animalis species consists of two subspecies, B. animalis subsp.…”

mentioning

confidence: 99%

Dissecting the Evolutionary Development of the Species Bifidobacterium animalis through Comparative Genomics Analyses

Lugli

Mancino

Milani

et al. 2019

Appl Environ Microbiol

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Bifidobacteria are members of the gut microbiota of animals, including mammals, birds, and social insects. In this study, we analyzed and determined the pangenome of Bifidobacterium animalis species, encompassing B. animalis subsp. animalis and the B. animalis subsp. lactis taxon, which is one of the most intensely exploited probiotic bifidobacterial species. In order to reveal differences within the B. animalis species, detailed comparative genomics and phylogenomics analyses were performed, indicating that these two subspecies recently arose through divergent evolutionary events. A subspecies-specific core genome was identified for both B. animalis subspecies, revealing the existence of subspecies-defining genes involved in carbohydrate metabolism. Notably, these in silico analyses coupled with carbohydrate profiling assays suggest genetic adaptations toward a distinct glycan milieu for each member of the B. animalis subspecies, resulting in a divergent evolutionary development of the two subspecies. IMPORTANCE The majority of characterized B. animalis strains have been isolated from human fecal samples. In order to explore genome variability within this species, we isolated 15 novel strains from the gastrointestinal tracts of different animals, including mammals and birds. The present study allowed us to reconstruct the pangenome of this taxon, including the genome contents of 56 B. animalis strains. Through careful assessment of subspecies-specific core genes of the B. animalis subsp. animalis/lactis taxon, we identified genes encoding enzymes involved in carbohydrate transport and metabolism, while unveiling specific gene acquisition and loss events that caused the evolutionary emergence of these two subspecies.

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“…extensively used as active ingredients in a variety of functional foods (14,15). The B. animalis species consists of two subspecies, B. animalis subsp.…”

mentioning

confidence: 99%

Dissecting the Evolutionary Development of the Species Bifidobacterium animalis through Comparative Genomics Analyses

Lugli

Mancino

Milani

et al. 2019

Appl Environ Microbiol

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“…Lactobacillus plantarum nF1 (nF1) is a LAB isolated from kimchi, a traditional Korean dish made using fermented cabbage that has been shown to exert beneficial effects on the immune system (Lee et al, 2016a;Choi et al, 2018). Consumption of heat-treated nF1-fortified yogurt has been shown to improve immune functions, including NK cell activity, in elderly individuals (Lee et al, 2017). Some L. plantarum strains have also been reported to exert protective effects against influenza viruses (Maeda et al, 2009;Arimori et al, 2012;Kikuchi et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Enhancing the natural killer cell activity and anti-influenza effect of heat-treated Lactobacillus plantarum nF1-fortified yogurt in mice

Kim

Chung

Chun

et al. 2018

Journal of Dairy Science

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Influenza A virus (IAV) infection is a global public health concern. It causes respiratory diseases ranging from mild illness to fatal disease. Natural killer (NK) cells are an innate immune component that kill infected cells and secrete cytokines to modulate the adaptive immune system; they constitute the first-line defense and play important roles in controlling IAV infection. This study evaluated the effect of daily administration of heat-treated Lactobacillus plantarum nF1-fortified yogurt on immunity and protection against IAV infection. Mice administered with heat-treated L. plantarum nF1-fortified yogurt showed elevated NK cell-related cytokine expression levels. Daily administration of the L. plantarum nF1-fortified yogurt before IAV infection also enhanced splenic NK activity, lung inflammatory cytokine responses, and survival rate. Thus, daily administration of nF1-fortified yogurt enhances host immunity and helps prevent IAV infection.These authors contributed equally to this study. 2 Corresponding authors: moonsong@ korea .ac .kr and kwangwon@ korea .ac .kr 10676 KIM ET AL.

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“…Also used as production of food and feed throughout the world [7][8][9][10][11] because widely used in the food industry for the production and the preservation of fermented products such as wholegrain sourdough bread or sourdough fermentation [12,13]. Daily consumption of dairy yogurt having Lactobacillus paracasei, and heattreated Lactobacillus plantarum possibly is successful alternative to improve immune function by enhancing IFN-γ concentration and NK cell function [14]. Probiotics can also survive on non-dairy foods under ambient storage conditions [15].…”

Section: Introductionmentioning

confidence: 99%

New Progress Regarding the Use of Lactic Acid Bacteria as Live Delivery Vectors, Treatment of Diseases and Induction of Immune Responses in Different Host Species Focusing on Lactobacillus Species

Shonyela¹,

Wang²,

Yang³

et al. 2017

J Prob Health

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Lactobacillus species are non-spore-forming, Gram-positive bacteria and lactic acid producing bacteria (LAPB) that naturally inhabits the human and animal gastrointestinal and mouth organs. The aim of this review was to evaluate the new progress regarding the use of Lactobacillus species as live delivery vectors, prevention and treatment of pathogenic and metabolic diseases. Lactobacillus strains as probiotics have been extensively studied and have confirmed that they can absolutely improve performance as live delivery vectors, a treatment option of various diseases such as: hemorrhagic cecal coccidiosis in young poultry, Hypertension, avian flu, obesity, diabetes, Derzsy's disease or parvovirus infection, human immunodeficiency virus infections, irritable bowel syndrome, gastrointestinal disorders, Fungal infections, vaginal eubiosis, fish and shellfish species diseases.We give you an idea about that Lactobacillus species have been proficient in preventing and treating both disorders in animal models and some used for clinical trials. We present the most current studies on the use of Lactobacillus strains that had an impact on an effective immune response to a specific antigen because a variety of antigens have been expressed. Therefore Lactobacillus strains can be considered as good candidates because of its potential for diseases treatment and vaccine development as heterologous protein secretion to date.

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Consumption of Dairy Yogurt Containing Lactobacillus paracasei ssp. paracasei, Bifidobacterium animalis ssp. lactis and Heat-Treated Lactobacillus plantarum Improves Immune Function Including Natural Killer Cell Activity

Cited by 94 publications

References 27 publications

Dissecting the Evolutionary Development of the Species Bifidobacterium animalis through Comparative Genomics Analyses

Dissecting the Evolutionary Development of the Species Bifidobacterium animalis through Comparative Genomics Analyses

Enhancing the natural killer cell activity and anti-influenza effect of heat-treated Lactobacillus plantarum nF1-fortified yogurt in mice

New Progress Regarding the Use of Lactic Acid Bacteria as Live Delivery Vectors, Treatment of Diseases and Induction of Immune Responses in Different Host Species Focusing on Lactobacillus Species

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