Consumption of Large Amounts of Allium Vegetables Reduces Risk for Gastric Cancer in a Meta-analysis

Zhou, Yong; Zhuang, Wen; Hu, Wen; Liu, Guan–Jian; Wu, Taixiang; Wu, Xiaoting

doi:10.1053/j.gastro.2011.03.057

Cited by 165 publications

(116 citation statements)

References 53 publications

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“…The findings for the antioxidative effects of shallot aqueous extracts reveal that in the ribose degradation assay all three shallot aqueous extracts appear to increase the amount of the Meta-analysis has shown that shallot reduces the risk of gastric cancer, but only if a large amount of shallot is consumed [11]. The solubility and bioavailability of exemestane, an irreversible aromatase inhibitor, has been found to greatly improve in powder and tablet form [20], so the beneficial effects of shallot powders prepared using these protocols are increased if the shallot powder is dissolved in water or other types of solvents.…”

Section: Discussionmentioning

confidence: 97%

“…The acceleration of gastric carcinogenesis by sodium chloride may be mediated by • OH [10]. Moreover, in a meta-analysis, consumption of large amounts of allium vegetables (onions, garlic, shallot) has recently been shown to reduce the risk of gastric cancer [11], but there is no credible evidence to support a relationship between garlic intake and a reduced risk of gastric, breast, lung or endometrial cancer [12]. Extracts of shallot have previously been shown to scavenge positively charged radical species, 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid), ABTS…”

Section: Introductionmentioning

confidence: 99%

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The Preparation of Preserved Shallot Powders and a Pilot Study of the Antioxidative Effect of Their Aqueous Extracts on the Formation of Hydroxyl Radical Species

Liang¹,

Hsu²,

Lan³

et al. 2012

OJAppS

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In order to preserve the nutrients in shallots, after harvest, various protocols, including incubation, drying or lyophilization of the shallot are developed in this study. Using aqueous extracts of ground shallot powders, this study examines the antioxidative properties of shallots on the formation of hydroxyl radical species (• OH) generated via a Fenton-type reaction. A ribose degradation assay shows that all aqueous extracts of shallot prepared in this study exhibit enhanced levels of • OH, suggesting that processed shallot, like strong reductants such as ascorbate, has a strong reducing power, which converts Fe 3+ to Fe 2+ in a Fenton's reaction and increases the levels of

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

The Preparation of Preserved Shallot Powders and a Pilot Study of the Antioxidative Effect of Their Aqueous Extracts on the Formation of Hydroxyl Radical Species

Liang¹,

Hsu²,

Lan³

et al. 2012

OJAppS

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show abstract

“…Moreover, in the analysis on supplements we used a random-effects model and excluded data from past use of garlic supplements (34) . Recently, two meta-analyses have been published showing the effects of garlic intake on gastric (39) and prostate cancer risk (40) . Similarly to our results, a preventive effect of garlic on gastric cancer was observed in three hospital-based case-control studies (OR = 0·57; 95 % CI 0·34, 0·80) and in eight population-based case-control studies (OR = 0·52; 95 % CI 0·37, 0·67), while one cohort study showed an increased risk (OR = 1·28; 95 % CI 0·45, 3·66) (39) .…”

Section: Discussionmentioning

confidence: 99%

Garlic consumption and colorectal cancer risk in man: a systematic review and meta-analysis

Chiavarini¹,

Minelli²,

Fabiani³

2015

Public Health Nutr.

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Objective: Colorectal cancer shows large incidence variations worldwide that have been attributed to different dietary factors. We conducted a meta-analysis on the relationship between garlic consumption and colorectal cancer risk. Design: We systematically reviewed publications obtained by searching ISI Web of Knowledge, MEDLINE and EMBASE literature databases. We extracted the risk estimate of the highest and the lowest reported categories of intake from each study and conducted meta-analysis using a random-effects model. Results: The pooled analysis of all fourteen studies, seven cohort and seven casecontrol, indicated that garlic consumption was not associated with colorectal cancer risk (OR = 0·93; 95 % CI 0·82, 1·06, P = 0·281; I 2 = 83·6 %, P ≤ 0·001). Separate analyses on the basis of cancer sites and sex also revealed no statistically significant effects on cancer risk. However, when separately analysed on the basis of study type, we found that garlic was associated with an approximately 37 % reduction in colorectal cancer risk in the case-control studies (combined risk estimate = 0·63, 95 % CI 0·48, 0·82, P = 0·001; I 2 = 75·6 %, P ≤ 0·001). Conclusions: Our results suggest that consumption of garlic is not associated with a reduced colorectal cancer risk. Further investigations are necessary to clarify the discrepancy between results obtained from different types of epidemiological studies.

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“…그 중 SAC는 allyl기에 황 원자가 첨가된 cysteine의 유도체로서 숙 성된 마늘에 다량 함유되어 있으며, 지난 수년간의 여러 연구 를 통하여 항산화, 항염증, 신경보호 및 항암기능 등을 포함한 다양한 생리적 활성효과를 갖는 것으로 보고되어 왔다 [15,21,35]. 그리고, 특히 마늘의 섭취가 암 발생의 감소뿐만 아니라 암의 진행을 억제하는 효과에 기여하는 것으로 보고됨에 따라 [4,36], 암의 예방과 치료를 위한 잠재적인 식품유래 화학요법 제로서 SAC를 포함하는 유기황화합물들이 다양한 유형의 암 세포에 대한 특이적 항암활성을 갖는 지에 대한 연구들이 진 행되어 왔다 [9]. 최근까지의 연구결과들을 분석한 보고에 따르 면 SAC가 세포주기의 억제, 암세포 전이 억제 및 독성물질로 부터 유도된 암화 과정을 억제하여 암의 발생 및 진행을 감소 시킬 뿐만 아니라, 암세포의 자멸을 유도하여 암의 성장을 억 제하는 것으로 제시되었다 [14].…”

Section: 서 론unclassified

S-allylcysteine-mediated Activation of Caspases and Inactivation of PARP to Inhibit Proliferation of HeLa

Kim¹,

Kong²,

Min³

2017

Journal of Life Science

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Our previous study suggested that S-allylcysteine (SAC) inhibits the proliferation of the human cervical cancer cell line, HeLa, at least in part through the induction of apoptosis and cell cycle arrest. To further analyze the specific molecular mechanism(s) by which SAC mediates its antiproliferative effects, this study examined the role of SAC in regulating the protein expression of initiator caspase (caspase-9), effector caspases (caspase-3 and caspase-7), and poly-ADP-ribose polymerase (PARP) in HeLa. Western blot analysis showed that when cells were treated with 50 mM SAC for 48 hr, the expression of procaspase-3, -7, and -9 and PARP was reduced by 94%, 38%, 95%, and 64%, respectively, as compared to the untreated control. In contrast, the expression of caspase-3, -7, and -9 and cleaved-PARP was markedly increased by SAC treatment. The SAC-mediated changes in the expression of these proteins were correlated with the concomitant inhibition of cellular proliferation by SAC. The cell proliferation assay showed that HeLa treatment with more than 20 mM SAC for 6-48 hr resulted in both concentration-and time-dependent inhibition of cellular proliferation. These results indicate that the SAC-induced antiproliferative effect in HeLa may be mediated at least in part through the activation of caspase-9, followed by the activation of caspase-3 and caspase-7 as well as the inactivation of PARP, thus leading to cellular apoptosis.

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Consumption of Large Amounts of Allium Vegetables Reduces Risk for Gastric Cancer in a Meta-analysis

Cited by 165 publications

References 53 publications

The Preparation of Preserved Shallot Powders and a Pilot Study of the Antioxidative Effect of Their Aqueous Extracts on the Formation of Hydroxyl Radical Species

The Preparation of Preserved Shallot Powders and a Pilot Study of the Antioxidative Effect of Their Aqueous Extracts on the Formation of Hydroxyl Radical Species

Garlic consumption and colorectal cancer risk in man: a systematic review and meta-analysis

S-allylcysteine-mediated Activation of Caspases and Inactivation of PARP to Inhibit Proliferation of HeLa

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