Consumption of Probiotic Lactobacillus fermentum MTCC: 5898-Fermented Milk Attenuates Dyslipidemia, Oxidative Stress, and Inflammation in Male Rats Fed on Cholesterol-Enriched Diet

Yadav, Radha; Khan, Suhail Hakeem; Mada, Sanusi Bello; Meena, Sunita; Kapila, Rajeev; Kapila, Suman

doi:10.1007/s12602-018-9429-4

Cited by 52 publications

(28 citation statements)

References 36 publications

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“…Yadav et al [ 29 ] reported that the consumption of probiotic L. fermentum MTCC: 5898-fermented milk not only attenuated dyslipidemia, but also reduced oxidative stress and inflammation in male rats fed a cholesterol-enriched diet. Oxidative stress was measured by the activity of various anti-oxidative enzymes, such as catalase, superoxide dismutase and glutathione peroxidase, and the level of thiobarbituric acid reactive substances (TBARS) in the liver and kidney—a marker of lipid peroxidation.…”

Section: Probioticsmentioning

confidence: 99%

Probiotics, Prebiotics and Synbiotics—A Promising Strategy in Prevention and Treatment of Cardiovascular Diseases?

Olas

2020

IJMS

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Recent evidence suggests that probiotics, prebiotics and synbiotics may serve as important dietary components in the prevention (especially) and treatment of cardiovascular diseases (CVD), but the recommendations for their use are often based on brief reports and small clinical studies. This review evaluates the current literature on the correlation between CVD and probiotics, prebiotics and synbiotics. Although research on probiotics, prebiotics and synbiotics has grown exponentially in recent years, particularly regarding the effect of probiotics on CVD, their mechanisms have not been clearly defined. It has been proposed that probiotics lower cholesterol levels, and may protect against CVD, by increasing bile salt synthesis and bile acid deconjugation. Similar effects have also been observed for prebiotics and synbiotics; however, probiotics also appear to have anti-oxidative, anti-platelet and anti-inflammatory properties. Importantly, probiotics not only have demonstrated effects in vitro and in animal models, but also in humans, where supplementation with probiotics decreases the risk factors of CVD. In addition, the properties of commercial probiotics, prebiotics and synbiotics remain undetermined, and further experimental research is needed before these substances can be used in the prevention and treatment of CVD. In particular, well-designed clinical trials are required to determine the influence of probiotics on trimethylamine-N-oxide (TMAO), which is believed to be a marker of CVDs, and to clarify the long-term effects, and action, of probiotic, prebiotic and synbiotic supplementation in combination with drug therapy (for example, aspirin). However, while it cannot be unequivocally stated whether such supplementation yields benefits in the prevention and treatment of CVDs, it is important to note that clinical studies performed to date have not identified any side-effects to use.

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Section: Probioticsmentioning

confidence: 99%

Probiotics, Prebiotics and Synbiotics—A Promising Strategy in Prevention and Treatment of Cardiovascular Diseases?

Olas

2020

IJMS

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“…The elucidation of differences in the mechanisms of action of T1D in humans and animals will facilitate experimental research and aid in discovering novel therapeutic strategies to ameliorate the T1D. Some of the most common animal models used to study the effect of probiotics, prebiotics and drugs on T1D are NOD mice [61], Streptozotocin (STZ)-induced T1D rats and mice [62,63], Alloxan-induced T1D Swiss Webster mice [64], BBDR rats [65,66], and Bio-Breeding Diabetic Pathogen (BBDP) rats [65,66]. The interactions of probiotics and prebiotics with gut microbiota and immune system and their involvement in T1D pathology are discussed separately for human and animal models.…”

Section: Role Of the Gut Microbiota-immune Axis In T1dmentioning

confidence: 99%

“…This was associated with decreased TNF-α and IL-6 levels but with no significant difference in the amount of TGF-β between control and treated rats [83]. The consumption of probiotic-fermented milk also helped in decreasing blood glucose levels, inflammation, oxidative stress and rate of gluconeogenesis [63,83]. Another study using diabetic rats concluded that the supplementation of probiotic strain L. plantarum appreciably reduced serum α-amylase action, favoring the glycemic index mechanism by restricting carbohydrate absorption and hydrolysis [84].…”

Section: Probiotic Interventions To Ameliorate T1dmentioning

confidence: 99%

Probiotics and Prebiotics for the Amelioration of Type 1 Diabetes: Present and Future Perspectives

et al. 2019

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Type 1-diabetes (T1D) is an autoimmune disease characterized by immune-mediated destruction of pancreatic beta (β)-cells. Genetic and environmental interactions play an important role in immune system malfunction by priming an aggressive adaptive immune response against β-cells. The microbes inhabiting the human intestine closely interact with the enteric mucosal immune system. Gut microbiota colonization and immune system maturation occur in parallel during early years of life; hence, perturbations in the gut microbiota can impair the functions of immune cells and vice-versa. Abnormal gut microbiota perturbations (dysbiosis) are often detected in T1D subjects, particularly those diagnosed as multiple-autoantibody-positive as a result of an aggressive and adverse immunoresponse. The pathogenesis of T1D involves activation of self-reactive T-cells, resulting in the destruction of β-cells by CD8+ T-lymphocytes. It is also becoming clear that gut microbes interact closely with T-cells. The amelioration of gut dysbiosis using specific probiotics and prebiotics has been found to be associated with decline in the autoimmune response (with diminished inflammation) and gut integrity (through increased expression of tight-junction proteins in the intestinal epithelium). This review discusses the potential interactions between gut microbiota and immune mechanisms that are involved in the progression of T1D and contemplates the potential effects and prospects of gut microbiota modulators, including probiotic and prebiotic interventions, in the amelioration of T1D pathology, in both human and animal models.

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“…Le TNF-α dérive principalement du tissu adipeux et contribue au dysfonctionnement endothélial et à la résistance à l'insuline, aussi bien, chez l'Homme que chez le rat [43,44]. Les mécanismes d'action du TNF-α ne sont pas encore bien élucidés mais il a été suggéré une diminution de l'ARNm de GLUT4 et une réduction du récepteur IRS (Insulin Receptor Substrate) [45]. Notre étude a bien mis en évidence, l'effet négatif de l'hypercholestérolémie, du diabète ainsi que leur association sur le statut inflammatoire, chez les rats puisqu'une augmentation des teneurs circulantes en CRP, TNF-α, IL-1β, IL-6 et en homocystéine, a été notée.…”

Section: Tnf- Homocystéine Et Protéine C-réactive (Crp)unclassified

Zygophyllum album aqueous extract reduces oxidative damage in erythrocytes and attenuates pro-inflammatory markers in hypercholesterolemic-diabetic rats

Bahlil¹,

Krouf²,

Taleb-Dida³

2020

Nutr. Santé

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Introduction. Zygophyllum album (Z. album) is used in traditional medicine for a long time for its anti-diabetic activities. Objective. To investigate Z. album extract supplementation effects on redox and inflammatory status in hypercholesterolemic-diabetic rats. Material and methods. Male Wistar rats (n=36), weighing 200±10g were divided into three groups (n=12). The 1st group was hypercholesterolemic (HC) by consuming cholesterol enriched diet (1%). The 2nd group was diabetic (D) by intraperi-toneal injection of streptozotocin (STZ) (35 mg/kg body weight). The 3rd group was hypercholesterolemic-diabetic (HC-D). Each group was divided into two subgroups (n=6), untreated (HC, D, HC-D) and treated groups with 1% Z. album extract (HC-Za, D-Za and HC-D-Za). Results. At d28, Z. album treatment lead to a decrease in erythrocytes thiobarbituric reactive substances (TBARS) in HC-Za (-44%), D-Za (-66%) and HC-D-Za (-23%) groups. Increased erythrocytes antioxidant enzymes activities (superoxide dismu-tase, glutathione peroxidase, glutathione reductase and catalase) were observed in HC-Za, D-Za and HC-D-Za (p<0.05). In plasma, interleukin (IL-1 β and IL-6) concentrations were reduced by -44, -50 and -33%, and -49, 38 and -41%, respectively in treated groups. In plasma, a decrease of TNF-α (Tumor Necrosis Factor-α), homocysteine and protein-C reactive (CRP) was observed in Z. album treated groups (p<0.05). Conclusion. Z. album reduces radical attack and improves anti-inflammatory proprieties in hypercholesterolemic-diabetic rats.

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Consumption of Probiotic Lactobacillus fermentum MTCC: 5898-Fermented Milk Attenuates Dyslipidemia, Oxidative Stress, and Inflammation in Male Rats Fed on Cholesterol-Enriched Diet

Cited by 52 publications

References 36 publications

Probiotics, Prebiotics and Synbiotics—A Promising Strategy in Prevention and Treatment of Cardiovascular Diseases?

Probiotics, Prebiotics and Synbiotics—A Promising Strategy in Prevention and Treatment of Cardiovascular Diseases?

Probiotics and Prebiotics for the Amelioration of Type 1 Diabetes: Present and Future Perspectives

Zygophyllum album aqueous extract reduces oxidative damage in erythrocytes and attenuates pro-inflammatory markers in hypercholesterolemic-diabetic rats

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