Consumption of Repeatedly Heated Soy Oil Increases the Serum Parameters Related to Atherosclerosis in Ovariectomized Rats

Adam, Siti Khadijah; Das, Srijit; Soelaiman, Ima Nirwana; Umar, Nor Aini; Jaarin, Kamsiah

doi:10.1620/tjem.215.219

Cited by 51 publications

(37 citation statements)

References 19 publications

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“…This may occur because the predominant plasma cholesterol in rodents is HDL, which comprises approximately 60～70% of the total cholesterol pool (45). Direct correlations between the LDL-C level and atherosclerosis have previously been reported (46,47). The changes in serum TC level observed in the present study are similar to those reported by Gossell-Williams et al (48), who found that supplementation with pumpkin seed oil decreased the TC levels in ovariectomized rats.…”

Section: Effects Of Ohs On the Serum Lipid Profilesupporting

confidence: 88%

Effects of Opuntia humifusa Seed Powder on Serum Lipid Profile in Ovariectomized Rats

Hahm¹,

Park²,

Son³

2011

JFN

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Opuntia humifusa contains high levels of antioxidants including vitamin C, flavonoids and polyphenols, which may provide beneficial effects such as hypolipidemic activity and the reduction of atherosclerosis in postmenopausal women. This study was conducted to determine if the intake of O. humifusa seeds powder (OHS) regulates lipid concentrations, glutamate-oxaloacetate transaminase (GOT), and glutamate-pyruvate transaminase (GPT) in the serum of ovariectomized rats. Sprague-Dawley female rats were randomly assigned to either a sham-operated group (Sham) or one of the following four ovariectomy (OVX) subgroups: OVX with vehicle (OVX), OVX with 100, 200, and 500 mg/kg/day OHS (OHS100, OHS200, OHS500). Daily oral administration of OHS was initiated one week after ovariectomy and continued for seven weeks. Upon completion of treatments, organs were weighed and GOT, GPT, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels were determined enzymatically. No significant differences in feed intake and organ index were observed among the groups. Significant decreases in GPT, TC and LDL-C (p<0.05) were observed in all of the OHS groups (OHS100, 200 and 500), while no significant changes in HDL-C were observed. In addition, the OHS200 and OHS500 treatment groups exhibited a lower level of serum GOT compared to the OVX group. These results indicate that supplementation with O. humifusa seeds could induce favorable changes in serum lipoprotein and lipid profiles, which frequently worsen with inadequate estrogen availability.

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Section: Effects Of Ohs On the Serum Lipid Profilesupporting

confidence: 88%

Effects of Opuntia humifusa Seed Powder on Serum Lipid Profile in Ovariectomized Rats

Hahm¹,

Park²,

Son³

2011

JFN

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“…In addition, repeatedly heated palm oil has reduced vitamin E constituents such as α -tocopherol, α -tocotrienol, γ -tocotrienol and δ -tocotrienol (Adam et al 2007). Consumption of repeatedly heated soy oil in post-menopausal state may contribute to the development of atherosclerosis because of increased lipid peroxidation (Adam et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Intake of Repeatedly Heated Palm Oil Causes Elevation in Blood Pressure with Impaired Vasorelaxation in Rats

Leong

Najib

Das

et al. 2009

Tohoku J. Exp. Med.

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“…Studies report that heated oils may increase the risk of cardiovascular diseases (CVD) by raising blood pressure, inducing oxidative stress, dyslipidemia and endothelial dysfunction (Adam et al, 2009;Ichihara, 2013;Ng et al, 2014;Xian et al, 2012). Adam et al (2008) reports lipid abnormalities induced by chronic consumption of heated oil in ovariectomised rats. Considering the cytotoxic products of heated oil, its effects on major organs such as liver and kidney may not be insignificant.…”

Section: Introductionmentioning

confidence: 99%

Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation

Famurewa¹,

Nwankwo

Folawiyo

et al. 2017

Acta Sci Pol Technol Aliment

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Background. The literature reports that the health benefits of vegetable oil can be deteriorated by repeated heating, which leads to lipid oxidation and the formation of free radicals. Virgin coconut oil (VCO) is emerging as a functional food oil and its health benefits are attributed to its potent polyphenolic compounds. We investigated the beneficial effect of VCO supplementation on lipid profile, liver and kidney markers in rats fed repeatedly heated palm kernel oil (HPO). Material and methods. Rats were divided into four groups (n = 5). The control group rats were fed with a normal diet; group 2 rats were fed a 10% VCO supplemented diet; group 3 administered 10 ml HPO/kg b.w. orally; group 4 were fed 10% VCO + 10 ml HPO/kg for 28 days. Subsequently, serum markers of liver damage (ALT, AST, ALP and albumin), kidney damage (urea, creatinine and uric acid), lipid profile and lipid ratios as cardiovascular risk indices were evaluated. Results. HPO induced a significant increase in serum markers of liver and kidney damage as well as concomitant lipid abnormalities and a marked reduction in serum HDL-C. The lipid ratios evaluated for atherogenic and coronary risk indices in rats administered HPO only were remarkably higher than control. It was observed that VCO supplementation attenuated the biochemical alterations, including the indices of cardiovascular risks. Conclusion. VCO supplementation demonstrates beneficial health effects against HPO-induced biochemical alterations in rats. VCO may serve to modulate the adverse effects associated with consumption of repeatedly heated palm kernel oil.

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Consumption of Repeatedly Heated Soy Oil Increases the Serum Parameters Related to Atherosclerosis in Ovariectomized Rats

Cited by 51 publications

References 19 publications

Effects of Opuntia humifusa Seed Powder on Serum Lipid Profile in Ovariectomized Rats

Effects of Opuntia humifusa Seed Powder on Serum Lipid Profile in Ovariectomized Rats

Intake of Repeatedly Heated Palm Oil Causes Elevation in Blood Pressure with Impaired Vasorelaxation in Rats

Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation

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