Consumption of sweeteners at different stages of life: effects on body mass, food and drink intake in male and female Wistar rats

Mendoza-Pérez, Samuel; García-Gómez, Rolando Salvador; Ordaz-Nava, Guillermo; Gracia-Mora, María Isabel; Macías-Rosales, Lucía; Morales-Rico, Héctor; Salas‐Garrido, Gerardo; Pérez-Armendáriz, E. Martha; Bustamante-García, Ruth; Durán-Domínguez-de-Bazúa, María del Carmen

doi:10.1080/09637486.2021.1888077

Cited by 2 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…rebaudiana and sucrose was tested. Furthermore, in the 2021 study [ 31 ] that non-nutritive sweeteners, when consumed alongside a balanced diet, do not cause significant increases in body mass. However, in the 2022 research [ 32 ], the group found that saccharin and nutritive sweeteners caused alterations in some glycolytic and lipogenic enzymes.…”

Section: Introductionmentioning

confidence: 99%

Stevia rebaudiana Bertoni, an American plant used as sweetener: Study of its effects on body mass control and glycemia reduction in Wistar male and female rats

Mendoza-Pérez,

Orta-Méndez-y-Sánchez,

García-Gómez

et al. 2024

PLoS ONE

Self Cite

View full text Add to dashboard Cite

Stevia rebaudiana Bertoni water extracts have been used as a natural sweetener and customary medicine by the indigenous inhabitants of South America for several hundred years. This plant was sent to Europe in the 16th century and was described by Peter Jacob Esteve in Spain. Recently the food industry has started to employ S. rebaudiana as sweetener using its glycosides after purification. Advertisement claims that Stevia glycosides is good for controling body mass and reducing glycemia. This study’s objective was to evaluate the effect of S. rebaudiana leaf extract on Wistar rats as animal model to prove its effectiveness on body mass control, glycemia reduction, and other biochemical parameters. Three groups were randomly formed with 24 males and 24 females: A blank group without any sweetener, a control group drinking water with 10% glucose, and the test group ingesting a 0.94% water extract of S. rebaudiana. Body mass measurements as well as food and drink consumption were daily performed. The experiment lasted 120 days after the specimens were weaned and got used to eating solid food. Euthanasia was done and blood serum was collected to evaluate the following biochemical parameters: Glucose, triglycerides, cholesterol, insulin, glucagon, leptin, ghrelin, and glucose-dependent insulinotropic peptide, GIP. Results indicated that only female rats had statistical differences in body mass gain. No relevant effects either positive or negative were found in the biochemical parameters measured. The crude extracts of S. rebaudiana did not show any relevant changes in biochemical and hormonal profiles, changes nor body mass with respect to the blank and control groups of young and healthy rats in the age range of infancy to youth. According to the results obtained, the therapeutic properties that have been associated to S. rebaudiana consumption especially for body mass control and glycemia reduction, did not occur in young and healthy male and female rats in equivalent age to infants, young children, and youths.

show abstract

Section: Introductionmentioning

confidence: 99%