Contact activation factors in plasma from women using oral contraceptives - increased levels of factor XII, kinin-free high molecular weight kininogen and acetone-activated kallikrein

Hoem, Nils; Johannesen, Steinar; Hauge, Gro; Rud, Anna C.; Sandem, Svend Øyvind; Briseid, Kjell

doi:10.1016/0049-3848(91)90343-u

Cited by 31 publications

(18 citation statements)

References 9 publications

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“…In healthy women taking oral contraceptives, Factor XII, prekallikrein, kallikrein, and kinin levels increase, and C1-INH levels decrease. [141][142][143][144][145][146][147] 7.2. Combined parenteral estrogen-progestin (patch and vaginal ring).…”

Section: Oral Contraceptive Pills Containing Estrogenmentioning

confidence: 99%

International consensus and practical guidelines on the gynecologic and obstetric management of female patients with hereditary angioedema caused by C1 inhibitor deficiency

Caballero

Farkas

Bouillet

et al. 2012

Journal of Allergy and Clinical Immunology

216

367

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Section: Oral Contraceptive Pills Containing Estrogenmentioning

confidence: 99%

International consensus and practical guidelines on the gynecologic and obstetric management of female patients with hereditary angioedema caused by C1 inhibitor deficiency

Caballero

Farkas

Bouillet

et al. 2012

Journal of Allergy and Clinical Immunology

216

367

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“…The plasma of these women shows enhanced in vitro fibrinolysis [15]. The contact system is also affected: Hageman factor, prekallikrein, kallikrein and high molecular weight kininogen increase [16-19]. This results in consumption of C1Inh; the decrease of C1Inh levels correlating with the increase in Hageman factor [15,16].…”

Section: Reviewmentioning

confidence: 99%

Hereditary angioedema in women

Bouillet

2010

All Asth Clin Immun

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Women with hereditary angioedema (HAE) are more likely to be symptomatic that men. Hormonal factors (puberty, contraception, pregnancy,....) play a significant role in the precipitation or worsening of the condition in women. So, combined contraceptive pills are not indicated and progestogen pill must be preferred. During pregnancy, attack rate can increase (38-48% of women). C1Inhibitor concentrate and tranexamic acid can be used during pregnancy. Attenuated androgens for long term prophylaxis are effective but side effects appear more often in female patients. These side effects are dose dependant and can be attenuated by titrating the dose down the lowest effective level.

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“…C1INH activity is normally decreased in pregnant women. In addition, increased levels of factor XII have been observed in women taking estrogenic contraceptive pills with high levels of estrogens [19,20]. Estrogens also increase B2-R gene expression and function [21].…”

Section: Possible Bradykinin-related Angioedemamentioning

confidence: 99%