Contact active antibacterial phosphonium coatings cured with UV light

Cuthbert, Tyler J.; Guterman, Ryan; Ragogna, Paul J.; Gillies, Elizabeth R.

doi:10.1039/c4tb01857e

Cited by 26 publications

(40 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our group recently reported a new route to tetraarylphosphonium polyelectrolytes having decomposition temperatures of up to 460 °C, with one that is stable at 65 °C in 6 M NaOH( aq ) for at least 24 h ( R3 in Scheme ) . Such robust properties are necessary for their use in antibacterial coatings and as membranes in alkaline fuel cells and related electrochemical energy conversion technologies …”

Section: Introductionmentioning

confidence: 99%

“…23 Our group recently reported a new route to tetraarylphosphonium polyelectrolytes having decomposition temperatures of up to 460 8C, with one that is stable at 65 8C in 6 M NaOH(aq) for at least 24 h (R3 in Scheme 1). 24 Such robust properties are necessary for their use in antibacterial coatings 25,26 and as membranes in alkaline fuel cells and related electrochemical energy conversion technologies. 27 Despite their intriguing properties, less work has been reported involving phosphonium salts in organic frameworks compared with the vast number of papers published every year related to organic polymer networks.…”

mentioning

confidence: 99%

See 1 more Smart Citation

A new route to phosphonium polymer network solids via cyclotrimerization

Yang

Wen

Chumanov

et al. 2017

J. Polym. Sci. Part A: Polym. Chem.

View full text Add to dashboard Cite

An organo‐main group network solid having tetrahedral phosphonium vertices was prepared from a diacetyl monomer via a straightforward cyclotrimerization reaction. The network solid composition was examined by FT‐IR spectroscopy and elemental microanalysis, revealing quantitative reaction of carbonyl moieties and a 67% degree of cross‐linking. The reaction yielded a material having a layered structure that is comprised of an amorphous polymer and which is thermally stable up to 370 °C in air with a char yield of 40% upon heating as high as 800 °C under N2. The polymer is stable to 6 M NaOH(aq) at 60 °C for 24 h and takes up only 10.63% of water by mass at room temperature. The surface morphology, as examined by AFM, revealed a very smooth as‐prepared film (RMS roughness of 3 nm). The specific surface area measured by BET analysis with N2 gas is 9 m2 g−1, indicating a type II, nonporous material. Physisorption with CO2 revealed that the phosphonium network solid has additional affinity for CO2, suggesting that such materials may have use for applications such as CO2 capture. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 1620–1625

show abstract

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

A new route to phosphonium polymer network solids via cyclotrimerization

Yang

Wen

Chumanov

et al. 2017

J. Polym. Sci. Part A: Polym. Chem.

View full text Add to dashboard Cite

show abstract

“…We also examined these materials as contact‐active antibacterial coatings . The good toughness of these crosslinked materials coupled with the high charge density at the surface provides an opportunity to fabricate long lasting and effective solutions to combat infections.…”

Section: Photopolymerized Ils and Their Applicationmentioning

confidence: 99%

“…We also examined these materials as contact-active antibacterial coatings. [66,67] The good toughness of these crosslinked materials coupled with the high charge density at the surface provides an opportunity to fabricate long lasting and effective solutions to combat infections. The key here is the simplicity in applying these materials on pre-existing substrates, such as railings and elevator buttons, with their longevity.…”

Section: Photopolymerized Il Coatingsmentioning

confidence: 99%

Photopolymerization of Ionic Liquids – A Mutually Beneficial Approach for Materials Fabrication

Guterman

Smith

2018

Israel Journal of Chemistry

Self Cite

View full text Add to dashboard Cite

Photopolymerization is a convenient fabrication technique with the power to control the polymerization in both time and space, be solvent free, and use simple equipment to initiate the polymerization reaction. These features are conditional on use of liquid monomers and crosslinkers that do not require solvent for processing. One class of compounds that provides these opportunities are ionic liquid (IL) monomers, which possess negligible vapour pressure and are free‐flowing liquids at room temperature. For these reasons, ILs and photopolymerization are complementary to each other towards the fabrication of electrolyte materials by circumventing the innate difficulty in processing PILs as melts. Instead, the electrolyte polymer is formed as a crosslinked material directly where it will be used. In this review, we outline recent work demonstrating the key benefits of this unlikely marriage, including formulation design, applications in coatings, membranes, and others.

show abstract

“…55 Nevertheless, the overall results suggest that the phosphonium-functionalized micelles have good potential to selectively kill bacteria. While further studies would be required to elucidate the in vitro and in vivo toxicity, previous studies have shown that phosphonium compounds can exhibit low in vitro, 36,56 and in vivo 56 toxicity. …”

Section: Hemolysis Of Red Blood Cellsmentioning

confidence: 99%

Phosphonium-Functionalized Polymer Micelles with Intrinsic Antibacterial Activity

2017

Self Cite

View full text Add to dashboard Cite

New approaches to treat bacterial infections are badly needed to address the increasing problem of antibiotic-resistance. This study explores phosphonium-functionalized block copolymer micelles as intrinsically antibacterial polymer assemblies. Phosphonium cations with varying alkyl lengths were conjugated to the terminus of a poly(ethylene oxide)-polycaprolactone block copolymer and the phosphonium-functionalized block copolymers were self-assembled to form micelles in aqueous solution. The size, morphology, and z-potential of the assemblies were studied and their abilities to kill Escherichia coli and Staphylococcus aureus were evaluated. It was found that the minimum bactericidal concentration depended on the phosphonium alkyl chain length and different trends were observed for Gram-negative and Gram-positive bacteria.The most active assemblies exhibited no hemolysis of red blood cells above the bactericidal 2 concentrations, indicating that they can selectively disrupt the membranes of bacteria.Furthermore, it was possible to encapsulate and release the antibiotic tetracycline using the assemblies, providing a potential multi-mechanistic approach to bacterial killing.

show abstract

Contact active antibacterial phosphonium coatings cured with UV light

Cited by 26 publications

References 40 publications

A new route to phosphonium polymer network solids via cyclotrimerization

A new route to phosphonium polymer network solids via cyclotrimerization

Photopolymerization of Ionic Liquids – A Mutually Beneficial Approach for Materials Fabrication

Phosphonium-Functionalized Polymer Micelles with Intrinsic Antibacterial Activity

Contact Info

Product

Resources

About