Contact allergens in topical corticosteroid vehicles: analysis of product composition

Dumycz, Karolina; Osinka, Katarzyna; Feleszko, Wojciech

doi:10.1111/cod.12693

Cited by 9 publications

(5 citation statements)

References 4 publications

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“…15,[56][57][58] Not only can AD mask underlying ACD, but the conditions can also mimic each other by involving similar areas such as the hands, lips, eyelids, and flexural locations. 15 Furthermore, topical treatments used for AD like emollients and corticosteroids [59][60][61][62] may contain allergens that can lead to sensitization; 38% of corticosteroid formulations were shown to contain common allergens. 62 Children with ACD and AD exhibit unique sensitization profiles compared to those with ACD alone, with increased reactions to substances found in topicals advertised for eczema such as cocamidopropyl betaine (CAPB), wool alcohol (lanolin), tixocortol-21-pivalate, and parthenolide.…”

Section: Comorbid Admentioning

confidence: 99%

“…15 Furthermore, topical treatments used for AD like emollients and corticosteroids [59][60][61][62] may contain allergens that can lead to sensitization; 38% of corticosteroid formulations were shown to contain common allergens. 62 Children with ACD and AD exhibit unique sensitization profiles compared to those with ACD alone, with increased reactions to substances found in topicals advertised for eczema such as cocamidopropyl betaine (CAPB), wool alcohol (lanolin), tixocortol-21-pivalate, and parthenolide. 57 Continued use of topical medicaments containing allergens may perpetuate dermatitis.…”

Section: Comorbid Admentioning

confidence: 99%

“…3,58,98 It is often used as a topical antibiotic for the treatment or prevention of superficial skin infections and is available as an over-the-counter preparation and in several corticosteroid formulations. 62 In patch testing, neomycin often coreacts with bacitracin, another topical antibiotic, because of its simultaneous use in triple antibiotics. 99…”

Section: Topical Antibioticsmentioning

confidence: 99%

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Pediatric allergic contact dermatitis. Part I: Clinical features and common contact allergens in children

Neale

Garza-Mayers

Tam

et al. 2021

Journal of the American Academy of Dermatology

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Allergic contact dermatitis (ACD), a delayed hypersensitivity skin reaction to environmental allergens, has a prevalence that is similar in children and adults. However, diagnostic testing for ACD in pediatric populations accounts for less than one tenth of all patch tests. The relative infrequency of pediatric patch testing may be attributed to the difficulty in testing in this population, which includes a smaller surface area for patch test placement and maintaining cooperation during patch testing, especially in younger children. Diagnosis can be difficult in children because the appearance of ACD can mimic other common pediatric skin conditions, particularly atopic dermatitis and irritant contact dermatitis. Comprehensive history taking, guided by patient presentation, age group, and location of dermatitis, helps build clinical suspicion. Such clinical suspicion is one of the major reasons behind patch testing, with additional indications being recalcitrant dermatitis and dermatitis with atypical distribution. US pediatric data have shown the top allergens to be metals, fragrances, topical antibiotics, preservatives, and emollients. These trends are important to recognize to guide management and accurate diagnosis, because ACD tends to persist if the allergen is not identified and can affect patients' quality of life.

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Section: Comorbid Admentioning

confidence: 99%

Section: Comorbid Admentioning

confidence: 99%

Section: Topical Antibioticsmentioning

confidence: 99%

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Pediatric allergic contact dermatitis. Part I: Clinical features and common contact allergens in children

Neale

Garza-Mayers

Tam

et al. 2021

Journal of the American Academy of Dermatology

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“…Our results showed that the ratios of products containing PG, parabens and triethanolamine were much higher than those of previous reports. [2][3][4] PG is an uncommon allergen and irritant; however, Patel et al 5 reported that the most common source of PG was topical medicaments, constituting 77.8% of relevant reactions. Parabens were identified in 56% of products in our study.…”

Section: Discussionmentioning

confidence: 99%

Analysis of total excipients of topical corticosteroids marketed in Korea

Choi,

Lee,

Lee

et al. 2024

Contact Dermatitis

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When we suspect topical corticosteroid (CS)-induced allergic contact dermatitis (ACD), it is important to obtain information about the vehicle as well as the active ingredients involved. For in the case of ACD caused by a component of vehicle it may not be helpful to avoid CS and its cross-reactors. Furthermore, CSs are applied to diseased skin. METHODSThis study included both prescription and non-prescription drugs sold in Korea between March and May 2023. Of the 930 products categorized as topical CSs by the Korean Index of Medical Specialties, 1 419 were in production at the time of the study. Excluding identical products with different dosages, a total of 204 products were studied.Listed components were matched with haptens in the Korean Standard Series (KSS), European Baseline Series (EBS), American Contact Dermatitis Society Core Allergen Series 2020 (ACDS) and Cosmetic Series (CoS) (Chemotechnique ® ) databases.

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“…In ophthalmology, it is used in the form of eye drops for bacterial conjunctivitis, and in otolaryngology for the treatment of otitis externa [ 6 ]. Unlike in Germany, neomycin (as well as gentamicin) is available in the USA as an over-the-counter preparation in combined steroid formulations (dexamethasone), with antifungal agents (nystatin) as well as together with bacitracin [ 16 , 18 , 19 ]. It is therefore one of the most common contact allergens in North America, with sensitization rates exceeding 8% [ 6 ].…”

Section: Contact Allergies To Topical Antibioticsmentioning

confidence: 99%

Contact allergies to topical antibiotic applications

Kreft¹,

Wohlrab²

2022

ALS

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Despite limited evidence on clinical efficacy and increasing resistance problems, topical antibiotics are still used in everyday clinical practice. However, topical antiseptic agents such, as octenidine and polyhexanide, often have a broader efficacy spectrum. They also have a broader target tropism because of their non-specific cellular mechanisms of action. Repeated use of topical antibiotics also carries the risk of contact sensitization, which could limit potential subsequent use as systemic antibiotics. Contact allergy is a clinically relevant problem, particularly in patients with barrier-damaged skin, pre-existing dermatosis, or occupational exposure. It can be concluded that with the use of modern antiseptics, topical antibiotic therapy is rarely indicated and should be avoided, not only because of the risk of contact sensitization but also because of the unfavorable and potentially consequential resistance problem.

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Contact allergens in topical corticosteroid vehicles: analysis of product composition

Cited by 9 publications

References 4 publications

Pediatric allergic contact dermatitis. Part I: Clinical features and common contact allergens in children

Pediatric allergic contact dermatitis. Part I: Clinical features and common contact allergens in children

Analysis of total excipients of topical corticosteroids marketed in Korea

Contact allergies to topical antibiotic applications

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