Contact allergies to topical corticosteroids

Abstract

The patient, a 34-year-old Japanese woman who noticed worsening of her rash after using topical corticosteroid preparations on her neck, was patch tested for both commercial preparations and corticosteroids themselves. The patch test results revealed that she had a contact allergy to gold, oxytetracycline, and 2 types of corticosteroid (acetonides and esters) in 7 compounds (betamethasone valerate and dipropionate, hydrocortisone butyrate and hydrocortisone butyrate propionate, amcinonide, budesonide, and fluocinonide).

Veterinary pharmacovigilance. Part 6. Predictability of adverse reactions in animals from laboratory toxicology studies

“…The effects on skin are arguably less predictable or at least less obvious. However, they have been used for many years in human medicine where they are known to cause sensitization and dermatitis (Sneddon, 1969;Verbov & Abell, 1969;Pasricha & Gupta, 1983;Boyle & Peachey, 1984;Dunkel et al, 1991;Hisa et al, 1993;Whitmore, 1994Whitmore, ,1995Alexiou et al, 1998;Nucera et al, 2002) and to induce dermal atrophy and telangiectasia (MacDonald, 1971;Lubach et al, 1989) and their ability to cause adverse skin effects in animals is therefore unsurprising.…”

“…However, they have been used for many years in human medicine where they are known to cause sensitization and dermatitis (Sneddon, 1969; Verbov & Abell, 1969; Pasricha & Gupta, 1983; Boyle & Peachey, 1984; Dunkel et al. , 1991; Hisa et al. , 1993; Whitmore, 1994,1995; Alexiou et al.…”

Cutaneous‐mucosal allergic contact reaction due to topical corticosteroids

“…Contact hypersensitivity is not limited to the skin after cutaneous administration (2, 5 , 14,16,17,19,29,30,32,37,38). Contact hypersensitivity is not limited to the skin after cutaneous administration (2, 5 , 14,16,17,19,29,30,32,37,38).…”

“…Bd is therapeutically applied topically to the skin and mucous membranes. Contact hypersensitivity is not limited to the skin after cutaneous administration (2, 5 , 14,16,17,19,29,30,32,37,38). There are several reports of worsening of rhinitis (13, 15, 21-23, 27, 31, 36) and rare cases of oral mucosa inflammation after nasal (2 1) or oral administration (20,26).…”

“…Furthermore, there is a need for markers of CS allergy, as it is impractical to test all patients with a complete CS series (6, 10, 11,33,41). Hypersensitivity has mainly been reported with CS applied to the skin (2, 5, 14,16,17,19,29,30,32,37,38), but reactions may also occur on mucosal surfaces (13, 15, 20-23, 26, 27, 31, 36), and after systemic administration (2, 6, 10, 11, 24, 28, 33, 34, 4 1).…”