Contact allergy to 2‐amino‐2‐methyl‐1‐propanol in a metalworking fluid

Geier, Johannes; Forkel, Susann; Heetfeld, Anne; Lessmann, Holger; Buhl, Timo

doi:10.1111/cod.13201

Cited by 12 publications

(2 citation statements)

References 4 publications

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“…Thus, the less harmful TEA underwent biodegradation and more accumulated in serum. Moreover, isobutanolamine (PLP5596, module 3) and phenyltoloxamine citrate (PLP460, module 3), both of which cause contact allergies ( 53 ), were also negatively correlated with uncultured bacterium clone 218002-1-48 (OTU17, P < 0.05). Consistently, these compounds were all positively associated ( P < 0.05) with rehospitalization for stroke.…”

Section: Discussionmentioning

confidence: 99%

Alterations of Gut Microbiome and Serum Metabolome in Coronary Artery Disease Patients Complicated With Non-alcoholic Fatty Liver Disease Are Associated With Adverse Cardiovascular Outcomes

Zhou

et al. 2022

Front. Cardiovasc. Med.

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Rationale: Patients suffering from coronary artery disease (CAD) complicated with nonalcoholic fatty liver disease (NAFLD) present worse cardiovascular outcomes than CAD patients without NAFLD. The progression of CAD is recently reported to be associated with gut microbiota and microbe-derived metabolites. However, it remains unclear how the complication of NAFLD will affect gut microbiota and microbe-derived metabolites in CAD patients, and whether or not this interplay is related to the worse cardiovascular outcomes in CAD-NAFLD patients.Methods: We performed 16S rRNA sequencing and serum metabolomic analysis in 27 CAD patients with NAFLD, 81 CAD patients without NAFLD, and 24 matched healthy volunteers. Predicted functional profiling was achieved using PICRUSt2. The occurrence of cardiovascular events was assessed by a follow-up study. The association of alterations in the gut microbiome and metabolome with adverse cardiovascular events and clinical indicators was revealed by Spearman correlation analysis.Results: We discovered that the complication of NAFLD was associated with worse clinical outcomes in CAD patients and critical serum metabolome shifts. We identified 25 metabolite modules that were correlated with poor clinical outcome in CAD-NAFLD patients compared with non-NAFLD patients, represented by increased cardiac-toxic metabolites including prochloraz, brofaromine, aristolochic acid, triethanolamine, and reduced potentially beneficial metabolites including estradiol, chitotriose, palmitelaidic acid, and moxisylyte. In addition, the gut microbiome of individuals with CAD-NAFLD was changed and characterized by increased abundances of Oscillibacter ruminantium and Dialister invisus, and decreased abundances of Fusicatenibacter saccharivorans, Bacteroides ovatus and Prevotella copri. PICRUSt2 further confirmed an increase of potential pathogenic bacteria in CAD-NAFLD. Moreover, we found that variations of gut microbiota were critically correlated with changed circulating metabolites and clinical outcomes, which revealed that aberrant gut microbiota in CAD-NAFLD patients may sculpt a detrimental metabolome which results in adverse cardiovascular outcomes.Conclusions: Our findings suggest that CAD patients complicated with NAFLD result in worse clinical outcomes possibly by modulating the features of the gut microbiota and circulating metabolites. We introduce “liver-gut microbiota-heart axis” as a possible mechanism underlying this interrelationship. Our study provides new insights on the contribution of gut microbiota heterogeneity to CAD-NAFLD progression and suggests novel strategies for disease therapy.

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Section: Discussionmentioning

confidence: 99%

Alterations of Gut Microbiome and Serum Metabolome in Coronary Artery Disease Patients Complicated With Non-alcoholic Fatty Liver Disease Are Associated With Adverse Cardiovascular Outcomes

Zhou

et al. 2022

Front. Cardiovasc. Med.

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“…Due to the wide variety and complex mechanism of DMARDs, the relationship between DMARDs and LUAD needs further study. 2-Amino-2-methyl-1-propanol (AMP) is a multifunctional additive used as dispersant, solvent, emulsi er, defoaming agent, and neutralizing agent, which is present in cosmetic lotions, spray hair gels, household detergents, dyes and pigments, paints, and pesticides, among other products (41). The AMP toxic effects were studied by Hossy et al in albino hairless mouse models, and they observed that sunscreen plus irradiation and vehicle plus irradiation lead to the thickening of the epidermis and increased dermal cellularity (42).…”

Section: Chemicals Related To Lung Squamous Cell Carcinoma By Gseamentioning

confidence: 99%

Identifying chemicals linked to lung cancer: Integrating genome-wide association studies with a chemical-gene interaction network

Lei

Tang

Gong

et al. 2020

Preprint

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Abstract Background Lung cancer is the most common cancer and the leading cause of cancer-related mortality worldwide. Environmental chemicals play a significant role in tumorigenesis, it is necessary to explore the lung cancer-related chemicals and provide new clues for neoplastic prevention and treatment. Methods The genome-wide association study (GWAS) summary data of malignant neoplasm of bronchus and lung (C34) were downloaded from the UK Biobank. It includes 1,655 samples and 450,609 controls. DNA methylation profiles of non-small cell lung cancer were obtained from the GEO database (GSE75008). A transcriptome-wide association study was applied to detect genes significantly related to lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) by FUSION software. Comparative toxicogenomics database (CTD) enables the construction of chemical-gene-disease networks. We conducted a chemical-related gene set enrichment analysis (GSEA) based on GWAS summary data, DNA methylation data, and the CTD to explore the relationships between chemicals and two major histological subtypes of lung cancer. Venn analysis was used to identify the common related chemicals of the GWAS summary data and the DNA methylation data. Results We detected aluminum, naringenin, and 2-acetylaminofluorene as LUSC-related chemicals and antirheumatic agents, nickel monoxide, and 2-amino-2-methyl-1-propanol as LUAD-related chemicals. Conclusion By integrating GWAS and chemical-gene interaction networks, we made linkages between various chemicals and lung cancer on genetic basis. Moreover, this study provided new clues for exploring the etiology of lung cancer and a new method for finding the chemicals related to tumor or other complex disease.

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Contact Allergy to Metalworking Fluids

Geier

Lessmann

2020

Contact Dermatitis

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Contact allergy to 2‐amino‐2‐methyl‐1‐propanol in a metalworking fluid

Cited by 12 publications

References 4 publications

Alterations of Gut Microbiome and Serum Metabolome in Coronary Artery Disease Patients Complicated With Non-alcoholic Fatty Liver Disease Are Associated With Adverse Cardiovascular Outcomes

Alterations of Gut Microbiome and Serum Metabolome in Coronary Artery Disease Patients Complicated With Non-alcoholic Fatty Liver Disease Are Associated With Adverse Cardiovascular Outcomes

Identifying chemicals linked to lung cancer: Integrating genome-wide association studies with a chemical-gene interaction network

Contact Allergy to Metalworking Fluids

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